Article
Biology
Artem K. Artamonov, Maria A. Kaneva, Natalia A. Gordeeva, Lubov S. Sorokina, Mikhail M. Kostik
Summary: Our study aimed to evaluate the clinical and laboratory features of juvenile idiopathic arthritis (JIA) children with temporomandibular joint (TMJ) arthritis. TMJ arthritis was detected in 43 (5.7%) of our patients and associated with a longer course of the disease, polyarticular JIA category, treatment with systemic corticosteroids, and longer achievement of remission and involvement of cervical spine, hip, and shoulder. Patients with TMJ arthritis require more biologics and have decreased probability of remission achievement.
Article
Pediatrics
Maria Francesca Gicchino, Pierluigi Marzuillo, Rosa Melone, Sarah Zarrilli, Emanuele Miraglia del Giudice, Alma Nunzia Olivieri, Anna Di Sessa
Summary: In addition to obesity, being underweight may also have a negative impact on the severity of Juvenile Idiopathic Arthritis (JIA) in children. Patients with underweight and severe obesity have worse disease outcomes in JIA, highlighting the importance of weight control in managing the disease.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Rheumatology
John G. Hanly, Lynn Lethbridge
Summary: Over the past 20 years, the use of disease-modifying antirheumatic drugs (DMARDs) and biologics has increased in older adults with rheumatoid arthritis (RA), while the use of corticosteroids (CS) has remained consistent. Further efforts are needed to minimize the use of CS in the long-term pharmacological management of RA.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Shiri Rubin, Orly Ohana, Ori Goldberg, Orit Peled, Yulia Gendler, Zohar Habot-Wilner, Yoel Levinsky, Rotem Tal, Liora Harel, Gil Amarilyo
Summary: This study compared the efficacy and safety of triamcinolone acetonide (TA) and triamcinolone hexacetonide (TH) for juvenile idiopathic arthritis (JIA) patients. The results showed similar recovery rates for both regimens, but TA had a more than double relapse rate compared to TH.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Rheumatology
Antia Garcia-Fernandez, Maria Chiara Gerardi, Francesca Crisafulli, Matteo Filippini, Micaela Fredi, Roberto Gorla, Maria Grazia Lazzaroni, Andrea Lojacono, Cecilia Nalli, Francesca Ramazzotto, Marco Taglietti, Cristina Zanardini, Sonia Zatti, Franco Franceschini, Angela Tincani, Laura Andreoli
Summary: The study focused on disease activity and obstetric outcomes in patients with JIA during pregnancy. Results showed that oligoarticular extended and polyarticular patients are more likely to experience disease flares, especially if they discontinue medications. Preterm delivery occurred in 20% of pregnancies with disease flares during pregnancy.
CLINICAL RHEUMATOLOGY
(2021)
Review
Dermatology
Anant Patil, Jun Lu, Martin Kassir, Mahsa Babaei, Mohamad Goldust
Summary: Dermatomyositis is a rare autoimmune inflammatory condition affecting skin and muscles. This review article provides comprehensive information about the treatment options for dermatomyositis, including traditional immunosuppressive agents, immunomodulatory therapy, and biological agents. Although several treatment options are available, there are still unanswered questions about the optimal treatment for dermatomyositis.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Pediatrics
Lubov S. Sorokina, Ilia S. Avrusin, Rinat K. Raupov, Natalia A. Lubimova, Sergey Khrypov, Mikhail M. Kostik
Summary: The study found that 20.3% of JIA patients had hip involvement, with 31.4% of them developing HOA. Factors associated with HOA development include sJIA, systemic corticosteroids, impaired calcium-phosphorus metabolism, and delayed hip arthritis. Factors associated with the need for THA include delayed initiation of biologic therapy, delayed hip involvement, and methylprednisolone pulse therapy.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Jiahui Qian, Emily Banks, Kristine Macartney, Anita Elizabeth Heywood, Marissa Nichole Lassere, Bette Liu
Summary: The use of systemic corticosteroids is associated with an increased risk of herpes zoster, with higher doses leading to greater risk. The risk peaks in the month following a single prescription but returns to baseline levels by the third month.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Rheumatology
Peter Stoustrup, Cory M. Resnick, Shelly Abramowicz, Thomas K. Pedersen, Ambra Michelotti, Annelise Kuseler, Bernd Koos, Carlalberta Verna, Ellen B. Nordal, Eric J. Granquist, Josefine Mareile Halbig, Kasper D. Kristensen, Leonard B. Kaban, Linda Z. Arvidsson, Lynn Spiegel, Matthew L. Stoll, Melissa A. Lerman, Mia Glerup, Patrizia Defabianis, Paula Frid, Per Alstergren, Randy Q. Cron, Sarah Ringold, Sven Erik Norholt, Timo Peltomaki, Tore A. Larheim, Troels Herlin, Zachary S. Peacock, Christian J. Kellenberger, Marinka Twilt
Summary: This study aimed to develop interdisciplinary recommendations for the management of orofacial manifestations of juvenile idiopathic arthritis (JIA) and to create a future research agenda for the treatment of temporomandibular joint (TMJ) arthritis in children with JIA. The recommendations were developed through online surveying, literature review, consensus meetings, and Delphi study iterations. Twelve recommendations and a future research agenda were outlined, filling an important gap in current clinical practice.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Beth Wallace, Meriah N. Moore, Andrew C. Heisler, Lutfiyya N. Muhammad, Jing Song, Daniel J. Clauw, Clifton O. Bingham, Marcy B. Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy D. Dunlop, Yvonne C. Lee
Summary: High fibromyalgianess is associated with persistent glucocorticoid use independent of inflammatory activity. Participants with high/very high baseline fibromyalgianess were more likely to be taking prednisone at follow-up relative to those with low fibromyalgianess.
Review
Neurosciences
Leandra Woolnough, Ariel Pomputius, Heather K. Vincent
Summary: The systematic review highlighted significant changes in gait among children with JIA, such as slower walking speed, shortened step length, and decreased range of joint motion. Exercise and pharmaceutical interventions have the potential to ameliorate these changes.
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Review
Nutrition & Dietetics
Renata Puppin Zandonadi
Summary: Nutrition plays a crucial role in the treatment, health, and life of patients with juvenile idiopathic arthritis (JIA). Suboptimal nutrition can adversely affect the long-term outcome of JIA patients, while correct nutritional status helps with recovery and inflammation reduction.
Article
Rheumatology
Natalie J. Shiff, Peter Shrader, Colleen K. Correll, Anne Dennos, Thomas Phillips, Timothy Beukelman
Summary: This study describes the trajectories of disease activity scores in patients with Juvenile Arthritis (JIA) over a two-year period. Five distinct trajectories were identified, and their associated baseline characteristics were analyzed.
Article
Rheumatology
Kiem Oen, Karine Toupin-April, Brian M. Feldman, Roberta A. Berard, Cia'ran M. Duffy, Lori B. Tucker, Jiahao Tian, Dax G. Rumsey, Jaime Guzman
Summary: This study validates the JIA parent global assessment as a valid measure of health-related quality of life. Comparisons with other HRQoL measures show good construct validity. However, reliability estimates and measurement errors were unsatisfactory, likely due to the time interval between assessments. Causal pathway analysis confirms previous findings.
Article
Allergy
Kathleen A. Lee-Sarwar, Yih-Chieh Chen, Yuan Yao Chen, Anita L. Kozyrskyj, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Hans Bisgaard, Jakob Stokholm, Bo Chawes, Soren J. Sorensen, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
Summary: This study found associations between prenatal and early-life fecal microbiomes and childhood asthma phenotypes. Cesarean section was found to increase the risk of early asthma.
Article
Rheumatology
Roberta Berard, Hon Yan Ng, Andrea Human, David Piskin, Muhammed Dhalla, Chloe Gottlieb, Michelle Batthish, Gaelle Chedeville, Christina Forest, Eric Fortin, Jane Gardiner, Kerstin Gerhold, Andre Jastrzebski, Bianca Lang, Paivi M. H. Miettunen, Sabrina Morgenstern, Marie-Paule Morin, Alan Rosenberg, Dax G. Rumsey, Carlos E. Solarte, Nasrin Tehrani, Karen Watanabe Duffy, Jordi Pardo Pardo, Glen S. Hazlewood, Deborah M. Levy
Summary: The objective of this study was to develop Canadian recommendations for the screening, monitoring, and treatment of uveitis associated with juvenile idiopathic arthritis (JIA). The study used the GRADE-ADOLOPMENT approach and involved a working group of healthcare professionals and patient representatives who reviewed existing recommendations and developed evidence-based recommendations specific to the Canadian context. The recommendations were generated through a survey, online discussions, and a virtual meeting.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Pediatrics
Brian R. Stotter, Ellen Cody, Hongjie Gu, Ankana Daga, Larry A. Greenbaum, Minh Dien Duong, Alexandra Mazo, Beatrice Goilav, Alexis Boneparth, Mahmoud Kallash, Ahmed Zeid, Wacharee Seeherunvong, Rebecca R. Scobell, Issa Alhamoud, Caitlin E. Carter, Siddharth Shah, Caroline E. Straatmann, Bradley P. Dixon, Jennifer C. Cooper, Raoul D. Nelson, Deborah M. Levy, Hermine Brunner, Priya S. Verghese, Scott E. Wenderfer
Summary: Children with lupus nephritis and stage 3 acute kidney injury have a high long-term risk of kidney failure. The severity of tubular atrophy and interstitial fibrosis at the time of acute kidney injury predicts kidney disease progression.
PEDIATRIC NEPHROLOGY
(2023)
Article
Rheumatology
Jonathan Park, Michelle Batthish, Roberta A. Berard, Gaelle Chedeville, Jean-Philippe Proulx-Gauthier, Dax G. Rumsey, Lori B. Tucker, Stephanie Wong, Jaime Guzman
Summary: Canadian pediatric rheumatology practices were generally in line with the 2019 JIA guideline recommendations, except for the frequent use of oral MTX and infrequent direct escalation from NSAIDs to bDMARDs in sacroiliitis and enthesitis.
Editorial Material
Primary Health Care
Laura Purcell, Erika Persson, Kristin Houghton
CANADIAN FAMILY PHYSICIAN
(2023)
Article
Rheumatology
Melissa C. Misztal, Fangming Liao, Madeline Couse, Jingjing Cao, Daniela Dominguez, Lynette Lau, Christian R. Marshall, Sergey Naumenko, Andrea M. Knight, Deborah M. Levy, Linda T. Hiraki
Summary: This study conducted genome-wide sequencing in children suspected of having monogenic lupus, and found that 13% of patients carried rare predicted damaging variants for monogenic lupus. Further studies are needed to validate these findings.
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Rheumatology
Jennifer J. Y. Lee, Roberta Berard, Deborah M. Levy, Vicki Ling, Jodi M. Gatley, Jessica Widdifield
JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Pediatrics
Kristin Houghton, Erika Persson, Laura Purcell
Summary: Choosing Wisely Canada (CWC) is an organization that aims to reduce unnecessary tests and treatments in Canada. A working group based on research, experience, and common practice patterns developed pediatric sport and exercise (SEM) recommendations. The final list comprises eight recommendations including imaging recommendations for various pediatric musculoskeletal conditions. Adhering to these recommendations may improve care and minimize unnecessary investigations and treatments.
PAEDIATRICS & CHILD HEALTH
(2023)
Article
Pediatrics
Tara McGrath, Jaime Guzman, Lori Tucker, Natalie J. Shiff, Maryna Yaskina, Susan Tupper, Dax G. Rumsey
Summary: Among newly diagnosed children with moderate pain in Juvenile Idiopathic Arthritis (JIA), female sex, lower overall quality of life, and higher enthesitis counts at baseline are predictors of the development of persisting pain.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Robyn K. Wojeck, Mitchell R. Knisely, Donald E. Bailey, Tamara J. Somers, Linda Kwakkenbos, Marie -Eve Carrier, Warren R. Nielson, Susan J. Bartlett, Vanessa L. Malcarne, Marie Hudson, Brooke Levis, Andrea Benedetti, Luc Mouthon, Brett D. Thombs, Susan G. Silva, SPIN Investigator
Summary: This study aimed to identify classes of individuals with similar symptom clusters in systemic sclerosis and evaluate associated characteristics. The majority of systemic sclerosis patients showed consistency between symptom levels and sociodemographic and disease-related variables. However, there was a group with low mental health symptoms despite high levels of other symptoms. This study highlights the importance of developing coping strategies and improving quality of life for systemic sclerosis patients.
Article
Hematology
Sarah M. Bowers, Bernard Ng, Sayeh Abdossamadi, Amina Kariminia, David A. Cabral, Geoffrey D. E. Cuvelier, Kirk R. Schultz, Kelly L. Brown
Summary: Adenosinergic signaling has context-specific effects on immune cells, particularly on lymphocytes. Changes in ADA2 enzyme activity may be associated with the onset of chronic GVHD.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)