Review
Rheumatology
Faekah Gohar, Daniel Windschall
Summary: This article reviews the role of musculoskeletal ultrasound (MSUS) in the diagnosis, monitoring, and treat-to-target management of JIA, highlighting its potential for more precise evaluation of arthritis and other conditions. It also discusses significant developments in defining normal and pathology in pediatric rheumatology, aiming to integrate MSUS for tighter control of disease activity and early identification of treatment response.
Article
Rheumatology
Tal El Tal, Meghan E. Ryan, Brian M. Feldman, Catherine April Bingham, Jon M. Burnham, Michelle Batthish, Danielle Bullock, Kerry Ferraro, Mileka Gilbert, Miriah Gillispie-Taylor, Beth Gottlieb, Julia G. Harris, Melissa Hazen, Ronald M. Laxer, Tzielan Chang Lee, Daniel Lovell, Melissa Mannion, Laura Noonan, Edward Oberle, Janalee Taylor, Jennifer E. Weiss, Cagri Yildirim Toruner, Esi M. Morgan
Summary: Treat to target (T2T) is recommended for neonatal idiopathic arthritis (JIA) treatment, but there are some barriers to its implementation. The consensus conference identified the importance of incorporating patient goals into target setting and the impact of patient stakeholder involvement in treatment recommendations. The findings will be used to modify the network approach to T2T.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Alessandra Alongi, Gabriella Giancane, Roberta Naddei, Valentina Natoli, Francesca Ridella, Marco Burrone, Silvia Rosina, Gaelle Chedeville, Ekaterina Alexeeva, Gerd Horneff, Ivan Foeldvari, Giovanni Filocamo, Tamas Constantin, Nicolino Ruperto, Angelo Ravelli, Alessandro Consolaro
Summary: This study aimed to investigate the frequency of a global assessment of disease activity (PhGA) >0 and an active joint count (AJC)=0 in children with juvenile idiopathic arthritis (JIA) and search for determinants of divergence between the two measures. The study found that many pediatric rheumatologists did not mark a score of 0 for patients who they found not to have active joints, and the presence of pain in joints not meeting the definition of active joint used in JIA was the main determinant of this phenomenon.
Article
Medicine, General & Internal
Elena Bolletta, Marco Coassin, Danilo Iannetta, Valentina Mastrofilippo, Raffaella Aldigeri, Alessandro Invernizzi, Luca de Simone, Fabrizio Gozzi, Alessandro De Fanti, Michela Cappella, Chantal Adani, Alberto Neri, Antonio Moramarco, Michele De Maria, Carlo Salvarani, Luigi Fontana, Luca Cimino
Summary: Biological drug treatment can improve visual outcomes after cataract surgery in patients with JIA-associated uveitis, but does not significantly reduce postoperative ocular complications. There was a significant difference in the improvement of corrected distance visual acuity between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Michelle M. A. Kip, Sytze de Roock, Gillian Currie, Deborah A. Marshall, Luiza R. Grazziotin, Marinka Twilt, Rae S. M. Yeung, Susanne M. Benseler, Sebastiaan J. Vastert, Nico Wulffraat, Joost F. Swart, Maarten J. IJzerman
Summary: This study investigates medication prescription patterns in children with JIA, revealing the complexity of pharmacological treatment in terms of the variety of mono- and combination therapies prescribed, significant variation in medication prescriptions between subtypes, most patients receiving multiple treatment lines, and a large number of unique treatment sequences.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Heather K. Vincent, Sharareh Sharififar, Bishoy Abdelmalik, Logan Lentini, Cong Chen, Leandra U. Woolnough
Summary: This study compared children with active or inactive JIA to healthy children and found that their gait and physical function performance was worse, indicating that specific load-bearing functional tasks and features of gait may serve as important biomarkers for assessing JIA burden and treatment efficacy.
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Rheumatology
Muge Sezer, Fatma Aydin, Tuba Kurt, Nilufer Tekgoz, Zahide Ekici Tekin, Cuneyt Karagol, Nilgun Cakar, Banu Acar
Summary: This study aimed to describe the clinical features of patients with oligoarticular juvenile idiopathic arthritis (JIA) who achieved inactive disease at the third month, and to determine predictors of relapse and extended course. Results showed that a lower JADAS27 score at admission increased the odds of achieving inactive disease at the third month, while factors such as ankle involvement, high JADAS27 score at admission, increased ESR at admission, and presence of synovial hypertrophy in imaging were identified as risk factors for relapse.
MODERN RHEUMATOLOGY
(2021)
Review
Nutrition & Dietetics
Renata Puppin Zandonadi
Summary: Nutrition plays a crucial role in the treatment, health, and life of patients with juvenile idiopathic arthritis (JIA). Suboptimal nutrition can adversely affect the long-term outcome of JIA patients, while correct nutritional status helps with recovery and inflammation reduction.
Article
Rheumatology
C. Bava, F. Mongelli, A. Pistorio, M. Bertamino, G. Bracciolini, S. Dalpra, S. Davi, S. Lanni, V Muratore, S. Pederzoli, S. Rosina, B. Schiappapietra, C. Suffia, G. C. Varnier, S. Verazza, G. Giancane, A. Consolaro, A. Ravelli
Summary: The study aimed to investigate the frequency of arthritis flare and factors affecting occurrence of flare in children with JIA who achieved inactive disease with MTX monotherapy. Results showed that 78.3% of patients experienced arthritis flare after a median of 1.6 years, with most flare episodes not treated with biologic therapy. The risk of flare was independent of withdrawal strategy, and majority of patients who had MTX withdrawn experienced flare.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Monika Ostrowska, Piotr Gietka, Malgorzata Manczak, Emil Michalski, Iwona Sudol-Szopinska
Summary: The study aimed to differentiate between hip arthritis in JIA and hip arthralgia of unknown etiology using MRI. MRI is effective in distinguishing between the two conditions, with good specificity in confirming a diagnosis of JIA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Saverio La Bella, Marta Rinaldi, Armando Di Ludovico, Giulia Di Donato, Giulio Di Donato, Vincenzo Salpietro, Francesco Chiarelli, Luciana Breda
Summary: This review evaluates the current understanding of the pathogenesis of JIA subtypes by examining the most relevant and up-to-date evidence. Despite significant improvements over the past decade, the exact cause and molecular mechanisms of JIA remain unclear. Complex interactions between genetic background and environmental factors, as well as the involvement of HLA haplotypes and non-HLA genes, contribute to the abnormal activation of immune cells and the inflammatory process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Milou Ohm, Joeri W. van Straalen, Marieke Zijlstra, Gerrie de Joode-Smink, Anne Jasmijn Sellies, Joost F. Swart, Sebastiaan J. Vastert, Joris M. van Montfrans, Marije Bartels, Annet van Royen-Kerkhof, Joanne G. Wildenbeest, Caroline A. Lindemans, Victorien M. Wolters, Roos A. W. Wennink, Joke H. de Boer, Mirjam J. Knol, Marloes W. Heijstek, Elisabeth A. M. Sanders, Frans M. Verduyn-Lunel, Guy A. M. Berbers, Nico M. Wulffraat, Marc H. A. Jansen
Summary: This study investigated the immunogenicity of the meningococcal serogroup ACWY conjugate vaccine in minors with juvenile idiopathic arthritis (JIA) and inflammatory bowel disease (IBD). The results showed that the concentrations of antibodies for serotypes A and W were lower in patients compared to healthy controls, and patients using anti-TNF therapy had lower immune response. Therefore, an extra booster vaccination should be considered for these patients.
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Rheumatology
Judith Wienke, Lauren M. Pachman, Gabrielle A. Morgan, Joo Guan Yeo, Maria C. Amoruso, Victoria Hans, Sylvia S. M. Kamphuis, Esther P. A. H. Hoppenreijs, Wineke Armbrust, J. Merlijn van den Berg, Petra C. E. Hissink Muller, Kyra A. Gelderman, Thaschawee Arkachaisri, Femke van Wijk, Annet van Royen-Kerkhof
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Pediatrics
E. Charlotte van Gulik, Floris Verkuil, Anouk M. Barendregt, Dieneke Schonenberg-Meinema, Amara Nassar-Sheikh Rashid, Taco W. Kuijpers, J. Merlijn van den Berg, Jan L. Hoving
PEDIATRIC RHEUMATOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anouk M. Barendregt, Valentina Mazzoli, E. Charlotte van Gulik, Dieneke Schonenberg-Meinema, Amara Nassar-Sheikh al Rashid, Charlotte M. Nusman, Koert M. Dolman, J. Merlijn van den Berg, Taco W. Kuijpers, AartJ Nederveen, Mario Maas, Robert Hamke
Article
Rheumatology
Dieneke Schonenberg-Meinema, Sandy C. Bergkamp, Amara Nassar-Sheikh Rashid, Leontien B. van der Aa, Godelieve J. de Bree, Rebecca ten Cate, Maurizio Cutolo, A. Elisabeth Hak, Petra C. E. Hissink Muller, Marieke van Onna, Taco W. Kuijpers, Vanessa Smith, J. Merlijn van den Berg
Summary: This study aims to describe capillary abnormalities in childhood-onset SLE patients and compare them with healthy controls. The results showed that cSLE patients had more abnormal capillary shapes and hemorrhages, which were correlated with disease activity and specific pathological features.
Article
Pediatrics
Veerle Heijstek, Meelad Habib, Roel van der Palen, Remco van Doorn, Petra Hissink Mueller
Summary: Neonatal macrophage activation syndrome (MAS) is a life-threatening inflammatory syndrome rarely associated with neonatal lupus. Symptoms include hyperferritinemia, elevated transaminases, hypertriglyceridemia, and the diagnosis can be challenging, requiring prompt treatment.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Pediatrics
Anouk Verwoerd, Wineke Armbrust, Katherine Cowan, Lotte van den Berg, Joke de Boer, Sanne Bookelman, Marjan Britstra, Jeannette Cappon, Maria Certan, Christine Dedding, Karin van den Haspel, Petra Hissink Muller, Karin Jongsma, Otto Lelieveld, Jorg van Loosdregt, Wendy Olsder, Johanna Rocha, Ellen Schatorje, Natasja Schouten, Joost F. Swart, Sebastiaan Vastert, Margot Walter, Casper G. Schoemaker
Summary: Involving end-users in setting research priorities is crucial to ensure research questions align with patient needs. This study aimed to generate a national research agenda for Juvenile Idiopathic Arthritis (JIA) with patients, caregivers, and clinicians. Through a nationwide survey and focus groups, the top 10 research priorities were identified, focusing on pain, fatigue, personalized treatment strategies, and etiology.
PEDIATRIC RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
M. J. Wahadat, C. G. Van Helden-Meeuwsen, S. Van Tilburg, E. Schatorje, E. Hoppenreijs, P. C. E. Hissink Muller, J. M. Van den Berg, D. Schonenberg-Meinema, S. Kamphuis, M. Versnel
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
D. Schonenberg-Meinema, S. Bergkamp, A. Nassar-Sheikh Rashid, M. Gruppen, A. E. Hak, P. C. E. Hissink Muller, M. Middelkamp, M. Van Onna, T. Kuijpers, V. Smith, J. M. Van den Berg
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
K. Spekking, P. De Boer, S. A. Bergstra, J. M. Van den Berg, D. Schonenberg-Meinema, L. W. A. Van Suijlekom-Smit, M. Van Rossum, Y. Koopman-Keemink, R. Ten Cate, C. Allaart, D. M. C. Brinkman, P. C. E. Hissink Muller
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Butsabong Lerkvaleekul, Saskia R. Veldkamp, Maria M. van der Wal, Ellen J. H. Schatorje, Sylvia S. M. Kamphuis, J. Merlijn van den Berg, Petra C. E. Hissink Muller, Wineke Armbrust, Sebastiaan J. Vastert, Judith Wienke, Marc H. A. Jansen, Annet Van Royen-Kerkhof, Femke van Wijk
Summary: Siglec-1 on monocytes is identified as a novel IFN-inducible biomarker in JDM, correlating with clinical disease activity and predicting treatment response. Patients with high Siglec-1 expression at diagnosis have a higher risk of requiring treatment intensification, and Siglec-1 expression is superior to the IFN score in predicting treatment response.
Article
Rheumatology
M. Javad Wahadat, Dieneke Schonenberg-Meinema, Cornelia G. van Helden-Meeuwsen, Sander J. van Tilburg, Noortje Groot, Ellen J. H. Schatorje, Esther P. A. H. Hoppenreijs, Petra C. E. Hissink Muller, Danielle M. C. Brinkman, Denis Dvorak, Marleen Verkaaik, J. Merlijn van den Berg, Katerina Bouchalova, Sylvia Kamphuis, Marjan A. Versnel
Summary: Translating existing transcriptomic data into simpler gene signatures suitable for stratifying SLE patients. The identified gene signatures were associated with disease activity and may guide future treatment choices.
Article
Rheumatology
Dieneke Schonenberg-Meinema, Sandy C. Bergkamp, Amara Nassar-Sheikh Rashid, Mariken P. Gruppen, Maritza A. Middelkamp-Hup, Wineke Armbrust, Koert Dolman, A. Elisabeth Hak, Petra C. E. Hissink Muller, Marieke van Onna, Joost F. Swart, Taco W. Kuijpers, Sylvia S. M. Kamphuis, Vanessa Smith, J. Merlijn van den Berg
Summary: This longitudinal study found that the majority of capillary patterns in childhood-onset SLE (cSLE) are abnormal and can change over time. Regardless of disease activity, a capillary scleroderma pattern in cSLE may be associated with a higher risk of SLE-related disease damage.
LUPUS SCIENCE & MEDICINE
(2022)
Meeting Abstract
Endocrinology & Metabolism
Maartje Meier, Marlous Hagelstein-Rotman, Olav Donker, Stijn Genders, Sarina Pichardo, Petra Hissink Muller, Michiel Van de Sande, Natasha Appelman-Dijkstra
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Rheumatology
Javad Wahadat, Dieneke Schonenberg-Meinema, Cornelia van Helden-Meeuwsen, Sander van Tilburg, Noortje Groot, Ellen Schatorje, Esther Hoppenreijs, Petra Hissink Muller, Danielle Brinkman, Denis Dvorak, Marleen Verkaaik, Katerina Bouchalova, Merlijn van den Berg, Sylvia Kamphuis, Marjan Versnel
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
S. C. Bergkamp, D. Schonenberg-Meinema, A. Nassar-Sheikh Rashid, K. Melsens, A. Vanhaecke, M. J. H. Boumans, P. C. E. Hissink Muller, M. Cutolo, T. W. Kuijpers, J. M. van den Berg, V Smith
Summary: The study demonstrates that different subtypes of capillary haemorrhages in childhood-onset SLE patients can be reliably reproduced by different raters, confirming recent observations of perivascular extravasations as a subgroup of capillary haemorrhages that may reflect endothelial dysregulation.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
