Review
Biochemistry & Molecular Biology
Hsiao-Chin Wang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: Oxygen therapy is important for newborns, but excessive oxygen levels can lead to intestinal inflammation and damage due to oxidative stress. Multiple molecular factors, including nitric oxide, NF-kappa B pathway, reactive oxygen species, toll-like receptor-4, etc., contribute to hyperoxia-induced intestinal injuries. The Nrf2 pathway and antioxidant cytokines or molecules play a role in preventing cell apoptosis and tissue inflammation. NF-kappa B and Nrf2 pathways are essential for maintaining oxidative stress balance and preventing cell apoptosis and tissue inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hsiu-Chu Chou, Chung-Ming Chen
Summary: This study evaluated the effects of cathelicidin treatment on lung ferroptosis and alveolarization in hyperoxia-exposed newborn rats. The results showed that cathelicidin can mitigate lung injury caused by hyperoxia and exert its effects by inhibiting ferroptosis.
Article
Obstetrics & Gynecology
Lan Kang, Wenbin Dong, Xiaobin Li, Ying Ruan, Rong Zhang
Summary: The study demonstrated that resveratrol can alleviate brain apoptosis induced by hyperoxia in neonatal rats by upregulating Sirt1-mediated pathways, indicating its potential therapeutic role in hyperoxia-induced brain injury.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Cell Biology
Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Exposure to high oxygen concentrations leads to excessive generation of reactive oxygen species, causing cellular injury and multiple organ dysfunctions. Clusterin (CLU) expression is increased during prolonged hyperoxia-induced lung injury, and replenishment of CLU can alleviate hyperoxia-induced cell death.
Article
Immunology
Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Christina T. Fulton, Adam M. Goldsmith, Antonia P. Popova
Summary: Premature infants with bronchopulmonary dysplasia (BPD) develop chronic respiratory symptoms after viral infections. Hyperoxia exposure increases activated lung dendritic cells (DCs) and proinflammatory responses in neonatal mice. This study found that early-life hyperoxia stimulates Flt3L expression, leading to expansion and activation of lung CD103+ DCs, thus mediating inflammation. In preterm infants, FLT3L levels positively correlated with proinflammatory cytokines levels and may contribute to the development of BPD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tong Zhang, Nicholas J. Day, Matthew Gaffrey, Karl K. Weitz, Kwame Attah, Patrice N. Mimche, Robert Paine, Wei-Jun Qian, My N. Helms
Summary: This study investigates the impact of high levels of oxygen on redox-dependent regulation in the lung, specifically focusing on the role of protein S-glutathionylation (SSG) in oxygen-induced lung injury. Through proteome-wide profiling, it was found that hyperoxia leads to significant alterations in SSG levels in various proteins. Additionally, overexpression of the beta-subunit of the epithelial sodium channel (Scnn1b) appears to protect against lung injury caused by hyperoxia. These findings highlight the importance of redox regulation in oxygen-induced lung injury and provide insights into potential protective mechanisms.
Article
Pharmacology & Pharmacy
Chie Kurihara, Reiko Sakurai, Tsai-Der Chuang, Alan J. Waring, Frans J. Walther, Virender K. Rehan
Summary: This study investigates the effects of hyperoxia exposure on lung injury and the inhibitory effects of the combination of pioglitazone and B-YL peptide using adult mouse lung explants. The results show that hyperoxia exposure activates the Wnt and TGF-beta signaling pathways, leading to abnormal expression of myogenic proteins and inflammatory cytokines, as well as alterations in key endothelial markers. However, these changes are largely mitigated by the combination of pioglitazone and B-YL peptide.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Medicinal
Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed, Eman K. Rashwan, Abdel-Gawad S. Shalkami, Ayman M. Mahmoud
Summary: The study showed that the natural NADPH oxidase inhibitor acetovanillone (AV) can protect rats from acute lung injury (ALI) induced by cyclophosphamide (CP) by attenuating oxidative stress and enhancing Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Nahla Zaghloul, Naomi S. Cohen, Kamesh R. Ayasolla, Hsiu-Ling Li, Dalibor Kurepa, Mohamed N. Ahmed
Summary: Prolonged oxygen therapy in preterm infants can lead to cognitive impairment. Galantamine, an FDA approved treatment for Alzheimer's disease, has shown potential in reducing hyperoxia-induced brain injury and improving learning and memory in neonatal mice. It can reduce neurodegeneration, increase acetyl choline levels, suppress inflammation, and improve neurobehavioral outcomes.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Ramazan Ozdemir, Ismail Kursat Gokce, Asli Cetin Taslidere, Kevser Tanbek, Cemile Ceren Gul, Suleyman Sandal, Hatice Turgut, Huseyin Kaya, Mehmet Aslan
Summary: The study findings suggest that prophylaxis with chrysin can reduce lung tissue damage scores, decrease apoptotic cell counts, inflammation, and oxidative stress while enhancing antioxidant capacity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Danyun Jia, Jinyu Zheng, Yiyang Zhou, Jinqiu Jia, Xiaoxiao Ye, Bingbing Zhou, Xingxing Chen, Yunchang Mo, Junlu Wang
Summary: The study used a HALI model to investigate the involvement of ferroptosis in hyperoxic acute lung injury. Pathological changes, iron deposition, and alterations in ferroptosis-related protein expressions were observed in the HALI group of neonatal rats compared to the normal control group, suggesting a potential role of ferroptosis in the pathogenesis of HALI.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell & Tissue Engineering
Hsiu-Chu Chou, Chien-Hsiang Chang, Chien-Han Chen, Willie Lin, Chung-Ming Chen
Summary: The consecutive intratracheal administration of surfactant and hUC-MSCs for two days effectively attenuated hyperoxia-induced lung injury in neonatal rats, demonstrating a potential therapeutic regimen for this condition.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zhengfei Fan, Yuan Shen
Summary: This study analyzed the effects of AQP-1, NF-kappa B, and apoptosis in neonatal rats with hyperoxia-induced lung injury. The results showed that targeting these factors can improve lung injury, inhibit inflammation and apoptosis, and have a certain protective effect.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Pediatrics
Jing Xiong, Qing Ai, Lei Bao, Yuanshan Gan, Xiaoyu Dai, Mei Han, Yuan Shi
Summary: This study aims to assess the effects of different doses of human umbilical cord-derived MSCs (hUC-MSCs) on a hyperoxia-induced bronchopulmonary dysplasia (BPD) model in newborn rats. The results show that intraperitoneal administration of a high dose of hUC-MSCs (1 x 107 cells) can effectively treat hyperoxia-induced BPD in neonatal rats.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Helena Hernandez-Cueryo, Jutaro Fukumoto, Sudarshan Krishnamurthy, Muling Lin, Matthew Alleyn, Mason Breitzig, Venkata Ramireddy Narala, Ramani Soundararajan, Richard F. Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: Acute lung injury (ALI) is a leading cause of mortality in older adults, and oxygen therapy is a common treatment method. Alda-1 protects against oxidative stress by enhancing ALDH2 activity, and also shows protective effects against ischemic reperfusion injury, heart failure, and other conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Ruben Vaidya, Donna Wilson, Yvonne Paris, Laura Madore, Rachana Singh
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Jun Wu, Wen-Jia Tian, Yang Liu, Huanhuan J. Wan, Jiangli Zheng, Xin Wang, Han Pan, Ji Li, Junyu Luo, Xuerui Yang, Lester F. Lau, H. Troy Ghashghaei, Qin Shen
Article
Multidisciplinary Sciences
Joon-Il Jun, Lester F. Lau
NATURE COMMUNICATIONS
(2020)
Article
Obstetrics & Gynecology
Ruben Vaidya, Alexander Knee, Yvonne Paris, Rachana Singh
Summary: The study found that infants with a gestational age greater than 26 weeks, birth weight over 750 g, PDA size less than 0.2 cm, and no prior indomethacin use were associated with successful PDA closure following acetaminophen treatment. A multivariable model identified gestational age greater than 26 weeks and PDA size less than 0.2 cm as the strongest predictors.
JOURNAL OF PERINATOLOGY
(2021)
Article
Medicine, General & Internal
Asimenia Angelidou, Katherine Sullivan, Patrice R. Melvin, Jessica E. Shui, Ilona Telefus Goldfarb, Ruby Bartolome, Neha Chaudhary, Ruben Vaidya, Ivana Culic, Rachana Singh, Diana Yanni, Silvia Patrizi, Mark L. Hudak, Margaret G. Parker, Mandy B. Belfort
Summary: This multicenter cohort study in Massachusetts examined the percentage of neonates born to mothers with positive SARS-CoV-2 test results and factors associated with neonatal test result positivity. The study found that maternal social vulnerability was a significant risk factor for neonatal test result positivity, and adverse outcomes in newborns were linked to preterm delivery due to worsening maternal COVID-19 symptoms.
Article
Obstetrics & Gynecology
Ruben Vaidya, Paul Visintainer, Rachana Singh
Summary: The study assessed the feasibility of measuring tidal volume in the delivery room and reported the tidal volume generated in intubated patients. The results showed that measuring tidal volume in the delivery room is feasible but associated with high intra and inter-patient variability.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Katherine Sullivan, Mandy B. Belfort, Patrice Melvin, Asimenia Angelidou, Aviel Peaceman, Jessica E. Shui, Ruben Vaidya, Rachana Singh, Ruby Bartolome, Silvia Patrizi, Neha Chaudhary, Ilona Telefus Goldfarb, Ivana Culic, Diana Yanni, Munish Gupta, Mark Hudak, Margaret G. Parker
Summary: Leveraging the Massachusetts PQC led to rapid changes in perinatal care during the COVID-19 crisis, with no differences in changes based on race/ethnicity, language status, or social vulnerability.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Ruben Vaidya, Edward Zitnik, Timothy Kita, Kathryn Wagner, Peter St Marie, Paul Visintainer, Rachana Singh
Summary: This study evaluated the physiologic changes during digital retinal imaging using near infra-red spectroscopy. The results showed slight improvements in cerebral and mesenteric perfusion without significant safety concerns during the imaging process.
JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Lara Rostomian, Asimenia Angelidou, Katherine Sullivan, Patrice R. Melvin, Jessica E. Shui, Ilona Telefus Goldfarb, Ruby Bartolome, Neha Chaudhary, Rachana Singh, Ruben Vaidya, Tina Steele, Diana Yanni, Silvia Patrizi, Ivana Culic, Margaret G. Parker, Mandy B. Belfort
Summary: The perinatal hospital care practices implemented during the early stage of the COVID-19 pandemic, such as mother-infant separation and prevention of breastfeeding initiation, had adverse effects on breastfeeding outcomes postdischarge.
BREASTFEEDING MEDICINE
(2022)
Article
Medicine, Research & Experimental
Naiyuan Cheng, Ki-Hyun Kim, Lester F. Lau
Summary: Senescent hepatic stellate cells play a critical role in liver regeneration by secreting IL-6 and CXCR2 ligands, which activate multiple signaling pathways to stimulate hepatocyte proliferation. The matricellular protein CCN1 is responsible for inducing senescence in hepatic stellate cells and promoting liver regeneration.
Article
Pediatrics
Ruben Vaidya, Joe X. Yi, T. Michael O'Shea, Elizabeth T. Jensen, Robert M. Joseph, Jeffrey Shenberger, Semsa Gogcu, Kathryn Wagner, Michael E. Msall, Amanda L. Thompson, Jean A. Frazier, Rebecca Fry, Rachana Singh
Summary: The growth impairment associated with surgical NEC and SIP may persist through late childhood, but there are no significant differences in neurodevelopmental outcomes among school-aged children born extremely preterm with any NEC or SIP compared to those Without NEC/SIP.
Article
Gastroenterology & Hepatology
Ki-Hyun Kim, Naiyuan Cheng, Lester F. Lau
Summary: CCN1 promotes liver macrophage clearance of apoptotic neutrophils, leading to the production of activated TGF-beta 1, which induces HSC transdifferentiation into myofibroblast-like cells and contributes to liver fibrosis.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Cell Biology
Ingrid Espinoza, Lin Yang, Travis Vander Steen, Luciano Vellon, Elisabet Cuyas, Sara Verdura, Lester Lau, Javier A. Menendez, Ruth Lupu
Summary: CCN1 promotes angiogenesis, tumor growth, and chemoresistance in endothelial and breast cancer cells by binding to its integrin receptor α(v)β(3). It also controls tissue regeneration by engaging its integrin receptor α(6)β(1) to induce fibroblast senescence. In estrogen receptor-positive breast cancer cells, CCN1 drives an endocrine resistance phenotype through its interaction with ER α.
Meeting Abstract
Pediatrics
Jessica Ohemeng-Dapaah, Keyur Donda, Fredrick M. Dapaah-Siakwan, Ruben Vaidya, Mustafa Caylan
Article
Endocrinology & Metabolism
Jelena Todoric, Giuseppe Di Caro, Saskia Reibe, Darren C. Henstridge, Courtney R. Green, Alison Vrbanac, Fatih Ceteci, Claire Conche, Reginald McNulty, Shabnam Shalapour, Koji Taniguchi, Peter J. Meikle, Jeramie D. Watrous, Rafael Moranchel, Mahan Najhawan, Mohit Jain, Xiao Liu, Tatiana Kisseleva, Maria T. Diaz-Meco, Jorge Moscat, Rob Knight, Florian R. Greten, Lester F. Lau, Christian M. Metallo, Mark A. Febbraio, Michael Karin
