Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease

The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?

(2016) Meritxell Huch et al.   HEPATOLOGY

A rapid and affordable screening platform for membrane protein trafficking

(2015) Joshua C. Snyder et al.   BMC BIOLOGY

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

(2015) R G Morgan et al.   BRITISH JOURNAL OF CANCER

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease

(2015) George K. Michalopoulos et al.   GASTROENTEROLOGY

Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions

(2015) J. C. Snyder et al.   JOURNAL OF CELL SCIENCE

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

R-spondin1 arguments hepatic fibrogenesis in vivo and in vitro

(2015) Yin Xinguang et al.   JOURNAL OF SURGICAL RESEARCH

Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis

(2014) Vincenzo Cardinale et al.   BMC GASTROENTEROLOGY

Liver cell reprogramming

(2014) Kilangsungla Yanger et al.   CELL CYCLE

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

R-Spondin2 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis

(2014) Xinguang Yin et al.   DIGESTIVE DISEASES AND SCIENCES

Stem Cells Marked by the R-Spondin Receptor LGR5

(2014) Bon-Kyoung Koo et al.   GASTROENTEROLOGY

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice

(2014) Hiroshi Suemizu et al.   LIVER TRANSPLANTATION

Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape

(2014) R. S. Kadzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cultured Hepatocytes Adopt Progenitor Characteristics and Display Bipotent Capacity to Repopulate the Liver

(2013) Petra Krause et al.   CELL TRANSPLANTATION

Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

(2013) Tae–Young Choi et al.   GASTROENTEROLOGY

Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish

(2013) Jianbo He et al.   GASTROENTEROLOGY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

(2013) Joshua C. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine synthetase expression in activated hepatocyte progenitor cells and loss of hepatocellular expression in congestion and cirrhosis

(2013) Kirsten E. Fleming et al.   LIVER INTERNATIONAL

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Recovery of Mature Hepatocytic Phenotype following Bile Ductular Transdifferentiation of Rat Hepatocytes in Vitro

(2012) Masayuki Sone et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

(2012) Regina Español–Suñer et al.   GASTROENTEROLOGY

Leucine-rich repeat-containing G protein-coupled receptor 5 expression in ductular reactions after chemotherapy for metastatic colorectal cancer

(2012) Susumu Saigusa et al.   HEPATOLOGY RESEARCH

Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure

(2012) Alex Hattoum et al.   HUMAN PATHOLOGY

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo

(2011) Vishakha S. Bhave et al.   HEPATOLOGY

The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis

(2011) Liping Liu et al.   HEPATOLOGY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Hepatic Progenitor Cell Proliferation and Liver Injury in α-1-Antitrypsin Deficiency

(2010) Elizabeth M Brunt et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

(2009) Andrea Haegebarth et al.   AMERICAN JOURNAL OF PATHOLOGY

The histogenesis of regenerative nodules in human liver cirrhosis

(2009) Wey-Ran Lin et al.   HEPATOLOGY

Liver regeneration: Alternative epithelial pathways

(2009) George K. Michalopoulos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium

(2008) Pallavi B. Limaye et al.   HEPATOLOGY

Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development

(2008) Pallavi B Limaye et al.   LABORATORY INVESTIGATION