Article
Multidisciplinary Sciences
Song Wu, Tao Tang, Hongchi Zhou, Jing Huang, Xiaoliang Kang, Junli Zhang
Summary: This study reveals that LINC01343 acts as a crucial oncogene in hepatocellular carcinoma (HCC). LINC01343 negatively regulates the expression of miR-526b-5p, which in turn modulates ROBO1 expression, affecting HCC cell proliferation and migration.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yuanjun Liu, Yakun Wu, Shuang Liu, Yi Dai
Summary: In HCC, TRIM52-AS1 is overexpressed and promotes proliferation and metastasis of HCC cells through the miR-218-5p/ROBO1 axis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cell Biology
Shuai Zhang, Yuan Lu, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, Shi Zhou
Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Yajie Guo, Junhua Yuan, Hao Ni, Jing Ji, Shuping Zhong, Yuxin Zheng, Qixiao Jiang
Summary: MiR-490-5p and its downstream genes SNAP91 and LYPD6 are involved in PFOA-induced developmental cardiotoxicity in chicken embryos, which helps to further understand the mechanism of PFOA-induced cardiac toxicity.
ENVIRONMENTAL POLLUTION
(2022)
Article
Oncology
Dan Yin, Zhi-Qiang Hu, Chu-Bin Luo, Xiao-Yi Wang, Hao-Yang Xin, Rong-Qi Sun, Peng-Cheng Wang, Jia Li, Jia Fan, Zheng-Jun Zhou, Jian Zhou, Shao-Lai Zhou
Summary: In hepatocellular carcinoma (HCC), genomic copy numbers of LINC01133 are increased and positively correlated with its expression. Higher copy number of LINC01133 predicts a poor prognosis in HCC patients. LINC01133 promotes HCC progression by sponging miR-199a-5p and interacting with ANXA2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Dezhi Li, Tao Zhou, Yaqin Li, Yanwei Xu, Xianyi Cheng, Junhui Chen, Wei V. Zheng
Summary: LINC02362 is identified as a potential tumor-inhibitory lncRNA that could serve as a biomarker for the prognosis of HCC and a promising therapeutic agent for patients with HCC.
Article
Biochemistry & Molecular Biology
Haihong Hu, Yu Wang, Zhiyuan Qin, Wen Sun, Yanhong Chen, Jiaqi Wang, Yingying Wang, Jing Nie, Lu Chen, Sheng Cai, Lushan Yu, Su Zeng
Summary: In this study, miR-4524-5p was found to downregulate the expression of MRP4, and circHIPK3 was shown to regulate MRP4 expression by sponging miR-124-3p and miR-4524-5p for the first time. These results may offer new insights into preventing MRP4-related proliferation and multiple drug resistance in HCC.
Article
Oncology
Rui Peng, Jun Cao, Bing-Bing Su, Xue-song Bai, Xin Jin, Ao-qing Wang, Qian Wang, Ren-jie Liu, Guo-qing Jiang, Sheng-jie Jin, Chi Zhang, Dou-sheng Bai
Summary: In this study, we discovered that circPTTG1IP, a circular RNA, acts as a tumor suppressor in hepatocellular carcinoma (HCC). Low expression of circPTTG1IP is associated with poor prognosis in HCC patients. Mechanistically, circPTTG1IP functions as a competing endogenous RNA (ceRNA) of RNF125 by binding miR-16-5p, thereby increasing the level of E3 ubiquitin ligase RNF125 and promoting the degradation of JAK1 protein. Filgotinib, a JAK1 inhibitor, can restrict HCC progression induced by low circPTTG1IP expression.
Article
Oncology
Jiantao Wang, Jinbiao Che
Summary: The study showed that circTP63 is significantly upregulated in HCC tissues and cell lines, and its high expression is associated with advanced tumor stages, lymph node metastasis, and poor prognosis in HCC patients. Mechanistically, circTP63 acts as a sponge for miR-155-5p to regulate ZBTB18 expression, which is negatively correlated with the survival rate of HCC patients, highlighting a critical regulatory network in HCC progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Yang Deng, La Wang, Yingjie Zhang, Dandan Sun, Hang Min, Hao Zhou, Chengchen Xu, Na Xu, Fengwu Qiu, Jingjiao Zhou, Jun Zhou
Summary: HBV-associated hepatitis B virus x protein (HBx) inhibits miR-187-5p expression, while overexpression of miR-187-5p inhibits proliferation, migration, and invasion of hepatocellular carcinoma cells. HBx enhances the expression of transcription factor E2F1, which in turn promotes the expression of FoxP3 and suppresses miR-187-5p. This study provides a theoretical basis for finding therapeutic targets for hepatocellular carcinoma.
Article
Medicine, Research & Experimental
Chunmei Huang, Ke Li, Rongfu Huang, Jianhua Zhu, Jiayao Yang
Summary: The study reveals that RNF185-AS1 is a new oncogenic lncRNA in HCC, with its high expression associated with tumor progression, distant metastasis, and overall survival rate. Knockdown of RNF185-AS1 inhibits cell proliferation, migration, and invasion in tumor cells.
Article
Cell Biology
Patricia de la Cruz-Ojeda, Tobias Schmid, Loreto Boix, Manuela Moreno, Victor Sapena, Juan M. Praena-Fernandez, Francisco J. Castell, Juan Manuel Falcon-Perez, Maria Reig, Bernhard Bruene, Miguel A. Gomez-Bravo, Alvaro Giraldez, Jordi Bruix, Maria T. Ferrer, Jordi Muntane
Summary: The study reveals that Sorafenib regulates a specific miRNA signature, where miR-200c-3p, miR-222-5p, and miR-512-3p have prognostic value and contribute to treatment response.
Article
Biochemistry & Molecular Biology
Hao Yang, Wensheng Sun, Tao Bi, Jiahao Sun, Zhihua Lu, Jie Li, Honglong Wei
Summary: In this study, it was found that miR-552-5p reduces sensitivity to ferroptosis in hepatocellular carcinoma (HCC) by targeting the 3' UTR of ACSL4 gene. Furthermore, the transcription factor ZNF8 was found to regulate the expression of miR-552-5p and enhance sensitivity to ferroptosis. These findings provide a new therapeutic target for HCC treatment.
DNA AND CELL BIOLOGY
(2023)
Article
Oncology
Zhibin Liao, Hongwei Zhang, Chen Su, Furong Liu, Yachong Liu, Jia Song, He Zhu, Yawei Fan, Xuewu Zhang, Wei Dong, Xiaoping Chen, Huifang Liang, Bixiang Zhang
Summary: In this study, it was demonstrated that SNHG14 is highly expressed in HCC tissues, with elevated expression predicting poor prognosis. SNHG14 promotes HCC cell proliferation and metastasis. It functions as a ceRNA for miR-876-5p, regulating the expression of SSR2 in HCC. Experimental evidence shows that miR-876-5p inhibits HCC progression in vitro and in vivo, with overexpression of SSR2 or knockdown of miR-876-5p reversing the suppressive effects of SNHG14 depletion in HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Xiangyu Qin, Lingyu Zhou, Yaojie Shen, Yuwei Gu, Jia Tang, Junwei Qian, An Cui, Mingquan Chen
Summary: The study found that circ0093335 is upregulated in hepatocellular carcinoma (HCC), and its expression is associated with tumor stage and invasiveness. Mechanistically, circ0093335 promotes HCC progression by downregulating miR-338-5p expression. These findings suggest that circ0093335 may be a potential therapeutic target for HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
