Article
Environmental Sciences
Amy E. Margolis, David Pagliaccio, Bruce Ramphal, Sarah Banker, Lauren Thomas, Morgan Robinson, Masato Honda, Tamara Sussman, Jonathan Posner, Kurunthachalam Kannan, Julie Herbstman, Virginia Rauh, Rachel Marsh
Summary: Prenatal exposure to environmental tobacco smoke may have detrimental effects on children's brain structure and function, affecting cognitive control and attention. The study results show that children exposed to ETS had smaller thalamic and inferior frontal gyrus volumes, and exhibited increased brain activation during cognitive conflict resolution.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Xin-Chen Liu, Esben Strodl, Chuan-An Wu, Li-Hua Huang, Xiao-Na Yin, Guo-Min Wen, Deng-Li Sun, Dan-Xia Xian, Wei-Qing Chen
Summary: Maternal exposure to environmental tobacco smoke (ETS) during pregnancy significantly increases the risk of preterm birth, with the highest risk observed when exposed in the first trimester.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Nadya Y. Rivera Rivera, Marcela Tamayo-Ortiz, Adriana Mercado Garcia, Allan C. Just, Itai Kloog, Martha Maria Tellez-Rojo, Robert O. Wright, Rosalind J. Wright, Maria Jose Rosa
Summary: Exposure to prenatal ETS modified the association between prenatal and early life PM2.5 exposure and respiratory outcomes at age 6-8 years, suggesting the importance of considering concurrent chemical exposures to more comprehensively characterize children's environmental risk. Interventions aimed at decreasing passive smoking might mitigate the effects of ambient air pollution.
ENVIRONMENTAL RESEARCH
(2021)
Review
Immunology
Agnieszka Kaczynska, Martyna Klosinska, Kamil Janeczek, Michal Zarobkiewicz, Andrzej Emeryk
Summary: This article introduces the immunomodulatory effects of bacterial lysates (BLs) on allergic disorders, discusses the correlation between local, innate, and adaptive immune responses, and reviews the outcomes of BLs in the prevention and treatment of atopic dermatitis, allergic rhinitis, and asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Anna V. Wiese, Jannis Duhn, Rabia Uelkue Korkmaz, Katharina M. Quell, Ibrahim Osman, Fanny Ender, Torsten Schroeder, Ian Lewkowich, Simon Hogan, Markus Huber-Lang, Franziska Gumprecht, Peter Koenig, Joerg Koehl, Yves Laumonnier
Summary: This study reveals the significant roles of C5aR1 in the trafficking and activation of inflammatory eosinophils, which have important implications for key aspects of allergic inflammation such as airway hyperresponsiveness, ILC2 cells, and T cell activation.
Article
Immunology
Imke Lingel, Adrienne N. Wilburn, Julie Hargis, Jaclyn W. McAlees, Yves Laumonnier, Claire A. Chougnet, Hitesh Deshmukh, Peter Koenig, Ian P. Lewkowich, Inken Schmudde
Summary: Changes in microbiome contribute to severity of allergic asthma. Prenatal antibiotic-induced dysbiosis leads to long-term immunological effects in offspring and increases asthma severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sjoerd T. T. Schetters, Martijn J. Schuijs
Summary: Eosinophils play multiple roles in immune responses, including defense against parasites, promoting allergic inflammation, and regulatory functions. They possess both homeostatic and pro-resolving capacity, but their function is influenced by time and space.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Martin Gaisberger, Romana Elisabeth Wass, Heidemarie Dobias, Fikreta Grabcanovic-Musija, Gertraud Weiss, Bernd Lamprecht, Bernhard Kaiser, Michael Studnicka, Arnulf Hartl
Summary: The study found that after 180 minutes of acute ETS exposure in asthma patients, there was an increase in respiratory symptoms, a decrease in lung function, and an increase in inflammatory cytokines.
Review
Neurosciences
Andrea L. Glenn, Leah K. Ragno, Jianghong Liu
Summary: This systematic review explores the association between postnatal ETS exposure and child conduct problems in studies that control for prenatal ETS exposure. Of the thirteen studies identified, nine reported a significant positive association of postnatal ETS exposure and child conduct-related behavior problems when controlling for prenatal ETS exposure. Results from tests of dose-response relationships were mixed. These findings highlight the significance of postnatal ETS exposure in conferring risk for conduct problems over and above prenatal ETS, and thus provide important information for guiding public health recommendations.
Review
Allergy
Timothy N. Perkins, Mason L. Donnell, Tim D. Oury
Summary: Asthma affects nearly 400 million people worldwide, with the majority of patients exhibiting a type 2-high phenotype and severe asthma often being associated with a type 2-low phenotype. The receptor for advanced glycation endproducts (RAGE) plays a significant role in asthma pathogenesis and allergic airway disease, especially in severe neutrophilic asthma.
Article
Environmental Sciences
Zixuan Wang, Hui Shi, Ling Peng, Yue Zhou, Ying Wang, Fei Jiang
Summary: This study found gender-specific differences in the association between environmental tobacco smoke exposure biomarkers and developmental disorders. Only girls with low cotinine levels and high urinary NNAL levels had higher odds of having developmental disorders, while the effects of boys and NNAL exposure were additive.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Siyu Dai, Chun Ting Au, Michael Ho Ming Chan, Richard Kin Ting Kam, Albert Martin Li, Kate Ching-Ching Chan
Summary: The study revealed that parental knowledge and attitude related to tobacco use and children's ETS exposure are insufficient and in need of improvement. Factors such as parental education level, household income, parental nicotine dependence level, and breastfeeding practice may predict more favorable parental KAP. The weak association between knowledge and practice highlights the need for additional interventions beyond education to reduce ETS exposure in children.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Allergy
Avery DeVries, Kathryn McCauley, Douglas Fadrosh, Kei E. Fujimura, Debra A. Stern, Susan Lynch, Donata Vercelli
Summary: This study examined the relationship between maternal prenatal immune dysfunction and childhood asthma risk, indicating associations with asthma development, neonatal immune training, and microbial colonization patterns in early life.
Article
Environmental Sciences
Mariah DeSerisy, Jacob W. Cohen, Jordan D. Dworkin, Jeanette A. Stingone, Bruce Ramphal, Julie B. Herbstman, David Pagliaccio, Amy E. Margolis
Summary: This study found that prenatal secondhand smoke exposure combined with early life stress could lead to increased internalizing symptoms in children during the preschool period and slower reduction of these symptoms over time. Maternal stress levels explained this association and provide guidance for personalized prevention measures.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
L. Campo, L. Boniardi, E. Polledri, F. Longhi, C. Scuffi, S. Fustinoni
Summary: This study assessed ETS exposure in Milan schoolchildren, revealing a higher actual exposure rate than perceived by parents. Children living with smokers or vapers had higher COT-U levels, with partial smoking bans showing a slight mitigation effect on exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Microbiology
Nathan das Neves Selis, Hellen Braga Martins de Oliveira, Hiago Ferreira Leao, Yan Bento dos Anjos, Beatriz Almeida Sampaio, Thiago Macedo Lopes Correia, Carolline Florentino Almeida, Larissa Silva Carvalho Pena, Mariane Mares Reis, Thamara Louisy Santos Brito, Lais Ferraz Brito, Guilherme Barreto Campos, Jorge Timenetsky, Mariluze Peixoto Cruz, Rachel Passos Rezende, Carla Cristina Romano, Andrea Miura da Costa, Regiane Yatsuda, Ana Paula Trovatti Uetanabaro, Lucas Miranda Marques
Summary: The study evaluated the potential in vitro probiotic properties of three strains of Lactiplantibacillus plantarum against Gardnerella vaginalis and Neisseria gonorrhoeae. Results showed that these strains exhibited significant probiotic characteristics against the two pathogens, making them strong candidates for in vivo studies for the treatment of vaginal infections.
Article
Agriculture, Dairy & Animal Science
Maysa Santos Barbosa, Joachim Spergser, Lucas Miranda Marques, Jorge Timenetsky, Renate Rosengarten, Rohini Chopra-Dewasthaly
Summary: This study used MALDI-ToF MS analysis to examine the differences between Mycoplasma agalactiae strains PG2 and GM139, and evaluated their Vpma phenotypic profiles. The results show that GM139 predominantly expresses VpmaV without phase variation, which may contribute to its differential pathogenicity compared to PG2.
Article
Environmental Sciences
Yang Jee Kim, Joong Won Lee, Yoon Hee Cho, Young Joo Choi, Younghyun Lee, Hai Won Chung
Summary: This study aimed to assess chromosomal instability in power plant workers exposed to occupational radiation at low doses in South Korea. The results showed that the frequency of chromosomal aberrations was significantly higher in workers exposed to low doses of radiation.
Article
Microbiology
Maysa Santos Barbosa, Lucas Miranda Marques, Jorge Timenetsky, Renate Rosengarten, Joachim Spergser, Rohini Chopra-Dewasthaly
Summary: To summarize, the hypothetical protein corresponding to MAG_6130 has not only been assigned novel adhesion functions but together with P40 it is demonstrated for the first time to bind to lactoferrin and ECM proteins thereby playing important roles in host colonization and pathogenicity.
Article
Microbiology
Verena M. Santos, Anne Karoline P. Brito, Aline T. Amorim, Izadora R. Souza, Maysa B. Santos, Guilherme B. Campos, Deborah C. dos Santos, Antonio Carlos R. Braga Junior, Jerusa M. Santana, Djanilson B. Santos, Marcio C. Mancini, Jorge Timenetsky, Lucas M. Marques
Summary: The present study evaluated the gut microbiota profiles of 40 women and found that gut microbiota was associated with obesity in women, and it was also related to inflammatory profiles and alterations in ghrelin and leptin levels.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thiago Macedo Lopes Correia, Amanda Alves Almeida, Danielba Almeida da Silva, Raildo da Silva Coqueiro, Ramon Alves Pires, Amelia Cristina Mendes de Magalhaes, Raphael Ferreira Queiroz, Lorena Lobo Brito, Lucas Miranda Marques, Marco Machado, Rafael Pereira
Summary: Regular physical training and cigarette smoke exposure have opposite effects on physical performance, antioxidant defense, and inflammatory profile. CSE attenuates the benefits of physical training, while promoting harmful pro-inflammatory effects and impairing antioxidant defense.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Microbiology
Manoel Neres Santos-Junior, Wanderson Souza Neves, Ronaldo Silva Santos, Palloma Porto Almeida, Janaina Marinho Fernandes, Bruna Carolina de Brito Guimaraes, Maysa Santos Barbosa, Lucas Santana Coelho da Silva, Camila Pacheco Gomes, Beatriz Almeida Sampaio, Izadora de Souza Rezende, Thiago Macedo Lopes Correia, Nayara Silva de Macedo Neres, Guilherme Barreto Campos, Bruno Lopes Bastos, Jorge Timenetsky, Lucas Miranda Marques
Summary: Ureaplasma diversum is a bacterial pathogen that infects cattle and can cause severe inflammation of the genital and reproductive systems. In this study, the researchers successfully expressed and purified recombinant GUDIV-103 (rGUDIV-103) and demonstrated its immunoreactivity and immunomodulatory effects in bovine peripheral blood mononuclear cells (PBMCs). They also showed that rGUDIV-103 induced lymphocyte proliferation and increased the expression of immune-related genes. These findings suggest that rGUDIV-103 has potential applications in immunobiology.
Article
Virology
Anna Carolina S. Dantas, Hellen B. M. Oliveira, Camila P. Gomes, Daniele L. Alves, Priscilla D. B. Infante, Rosimara de J. A. Caitite, Hegger M. Fritsch, Marina S. Cucco, Lucas S. C. Silva, Caline N. T. Oliveira, Rafaela de S. Bittencourt, Aline T. Amorim, Ana Luisa P. Nascimento, Francely A. G. C. Marinho, Danielle S. de Medeiros, Marcio G. G. de Oliveira, Sostenes Mistro, Fabricio F. de Melo, Taiana T. S. Pereira, Ana M. S. Guimaraes, Jorge Timenetsky, Pablo Maciel B. Moreira, Sandra Helena P. de Oliveira, Luiz C. J. Alcantara, Marta Giovanetti, Luciane A. Santos, Vagner Fonseca, Fernanda K. Barreto, Guilherme B. Campos, Lucas M. Marques
Summary: This study aimed to identify risk factors for mortality from SARS-CoV-2 infection, evaluate gene expression patterns of immune response pathways in COVID-19 patients, and identify circulating SARS-CoV-2 variants in a medium-sized city in Northeast Brazil. The study found that pre-existing comorbidity, male gender, cardiovascular disease, diabetes, chronic obstructive pulmonary disease, and PCR cycle threshold values under 22 were identified as risk factors for mortality. Furthermore, the study demonstrated that the severity of infection was associated with increased activation of inflammatory pathways, and multiple lineages of the virus were circulating.
Article
Microbiology
Aline Teixeira Amorim, Vanesca de Souza Lino, Lucas Miranda Marques, Davi Jardim Martins, Antonio Carlos Ricardo Braga Junior, Guilherme Barreto Campos, Caline Novais Teixeira Oliveira, Enrique Boccardo, Jorge Timenetsky
Summary: Mycoplasma hominis infection affects the cell cycle and inflammatory response of human keratinocytes. Infection leads to cellular damage, activates cell cycle regulation and apoptosis progression, increases oxidative stress response, activates Toll-like receptor pathways, and results in reduced cell proliferation/viability.
Article
Multidisciplinary Sciences
Lais Ferraz Brito Sousa, Hellen Braga Martins Oliveira, Nathan das Neves Selis, Lorena Lobo Brito Morbeck, Talita Costa Santos, Lucas Santana Coelho da Silva, Jully Chayra Santos Viana, Mariane Mares Reis, Beatriz Almeida Sampaio, Guilherme Barreto Campos, Jorge Timenetsky, Regiane Yatsuda, Lucas Miranda Marques
Summary: The study evaluated the biological activities of the BCP-DHA combination in in vitro and in vivo experimental models of antinociception and inflammation. The results showed that BCP-DHA had significant anti-inflammatory and antinociceptive effects.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Valdiele de Jesus Salgado, Caio Marcellus Pereira de Abreu Oliveira, Agatha Morgana Bertoti da Silva, Henrique Inacio Lima de Brito, Danielle Souto de Medeiros, Fabiane Soares, Laio Magno, Ines Dourado, Guilherme Barreto Campos, Lucas Miranda Marques
Summary: This study investigated the prevalence of Mollicutes among adolescent MSM and TGW aged 15 to 19. The results showed a high prevalence of infection at extragenital sites. Further research is needed to understand the epidemiological characteristics of high-risk adolescents in different regions and contexts, as well as the pathogenesis of Mollicutes in the oral and anal mucosa.
BMC INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Deborah Cruz Dos Santos, Rafaela de Souza Bittencout, Iago Dorea Areas, Larissa Silva C. Pena, Carolline Florentino Almeida, Bruna Carolina de Brito Guimaraes, Rafael Santos Dantas Miranda Dorea, Thiago Macedo Lopes Correia, Manoel Neres Santos Junior, Lorena Lobo Brito Morbeck, Talita Costa Dos Santos, Clarissa Leal S. Souza, Samira Itana de Souza, Telma de Jesus Soares, Regiane Yatsuda, Guilherme Barreto Campos, Lucas Miranda Marques
Summary: This study evaluated the influence of the hormone 5-alpha-dihydrotestosterone (DHT) on the immune response of mouse peritoneal macrophages (MPMs) and human peripheral blood monocytes (HPBMs) induced by Staphylococcus aureus (S. aureus) infection. The results showed that DHT acts as an inflammatory modulator in the monocyte/macrophage response induced by S. aureus, and females exhibit a better immune defense response against this pathogen.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Medicine, General & Internal
Fillipe Dantas Pinheiro, Luana Weber Lopes, Rafael Santos Dantas Miranda Dorea, Glauber Rocha Lima Araujo, Filipe Antonio Franca da Silva, Breno Bittencourt de Brito, Maria Luisa Cordeiro Santos, Geovani Moreno Santos Jr, Maria Teresa Araujo de Lorenzo Barcia, Renata de Amorim Marques, Andre Bezerra Botelho, Anna Carolina Saude Dantas, Davi Tanajura Costa, Adriano Fernandes Teixeira, Claudio Lima Souza, Lucas Miranda Marques, Guilherme Barretos Campos, Marcio Vasconcelos Oliveira, Dulciene Maria de Magalhaes Queiroz, Fabricio Freire de Melo
Summary: This study investigated the epidemiological and clinical features of severely ill COVID-19 patients in an intensive care unit in northeastern Brazil. Results showed that dyspnea was the most frequent symptom, affecting 73.9% of patients, followed by cough (54.7%). The presence of two or more comorbidities increased the risk of mortality, and lower platelet count was positively associated with death. Nausea and vomiting were two symptoms that predicted death, while the presence of a cough was a protective factor.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Public, Environmental & Occupational Health
Mateus Rodrigues Westin, Yuppiel Franmil Martinez, Ana Paula Silva, Marilia Greco, Lucas Miranda Marques, Guilherme Barreto Campos, Matheus de Paula Alves, Alessandra Mancuzzo, Unai Tupinambas, Dirceu Bartolomeu Greco
Summary: Syphilis is a significant public health problem in Brazil and globally, particularly affecting MSM and TrTGW. There is limited research on STIs in adolescents from these key populations. This Brazilian multi-center study focused on sexually active MSM and TrTGW adolescents and found a high prevalence of syphilis. Risk factors included STI history, sex work, and low education level. This study highlights the urgent need to strengthen public health programs addressing race, gender, sexuality, and prevention.
CADERNOS DE SAUDE PUBLICA
(2023)
Meeting Abstract
Pathology
J. Carneiro Melo, G. Bitu Dos Santos Ponte, V. Holanda Ferreira, P. V. Pereira Motoyama, I. M. Barbosa Bonfim De Morais, I. Correa Cavalcanti Sa, L. Matias Marques, E. Ribeiro De Lemos, L. Lima Barros, G. Alencar De Medeiros, M. Luiz Balancin, G. Ferreira Morgantetti