Article
Clinical Neurology
Jun-ying Li, Nan-nan Li, Ling Wang, Jia-xin Peng, Li-ren Duan, Chao-lan Chen, Rong Peng
Summary: This study reported a female from a Chinese family diagnosed with juvenile PD and treated with levodopa/benserazide throughout pregnancy. Results showed that the genetic testing of the patient was consistent with the PD phenotype and exhibited an autosomal recessive pattern. The patient's PD symptoms remained stable during pregnancy with levodopa/benserazide treatment.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Hong-xing Li, Mei Dong, Xiao-xiao Peng, Yi-zhe Liu, Han Wang, Chao Li, Yi-yi Du, Kai Zhang, Qiang Zong
Summary: In this study, a case was reported of a young woman with PRKN-associated Young-Onset Parkinson's disease (YOPD) who was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through a uncomplicated vaginal delivery. This case further suggests the safety of levodopa/benserazide during pregnancy in the treatment of PRKN-associated YOPD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Gabrielle Bispo, Caio S. Silva, Camille Sena-dos-Santos, Dafne Dalledone Moura, Brenda Hanae Bentes Koshimoto, Bruno Lopes Santos-Lobato, Andrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Summary: Mitophagy dysfunction caused by gene mutations is associated with the development of Parkinson's Disease (PD). However, the association between the variants of mitophagy-related genes and the treatment with levodopa (LD) in PD patients has not been well explored. This study investigated the association of 14 variants of the PRKN gene with LD treatment in PD patients. The results suggest that while age at onset of symptoms, duration of PD, and LD treatment and dosage can influence the occurrence of dyskinesia, the investigated PRKN variants did not show a significant association.
Review
Pharmacology & Pharmacy
Peter Kempster, Andrew Ma
Summary: A large proportion of drugs for neurological disorders are derived from naturally occurring compounds, especially plant alkaloids. The treatment of Parkinson's disease has strong botanical origins, with plant-derived substances playing a significant role. The interaction between plant compounds and animal dopaminergic systems has deep evolutionary roots.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy, Awanish Mishra
Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Piniel Alphayo Kambey, Wen Ya Liu, Jiao Wu, Chuanxi Tang, Wokuheleza Buberwa, Adonira Saro, Alphonce M. K. Nyalali, Dianshuai Gao
Summary: This study revealed the crucial role of Amphiregulin (Areg) gene in levodopa-induced dyskinesia in Parkinson's disease. Inhibition of Areg was found to alleviate dyskinetic movements and decrease the expression of related proteins. Therefore, Areg may serve as a potential target for therapy development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Eva Schaeffer, Thomas Vaterrodt, Laura Zaunbrecher, Inga Liepelt-Scarfone, Kirsten Emmert, Benjamin Roeben, Morad Elshehabi, Clint Hansen, Sara Becker, Susanne Nussbaum, Jan-Hinrich Busch, Matthis Synofzik, Daniela Berg, Walter Maetzler
Summary: Our independent analysis of three PD cohorts consisting of a total of 1124 PD patients found that patients taking Levodopa CR reported a significantly higher burden of nocturnal akinesia. Higher Levodopa intake and MDS-UPDRS part IV scores predicted worse quality of sleep and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Yu-tong Zhao, Li Liu, Yong Zhao, Zong-yi Xie
Summary: The study found that levodopa alone therapy may be superior in motor symptom relief for early Parkinson's disease patients compared to levodopa-sparing therapy, and the motor advantage of levodopa alone may increase over time. Levodopa alone therapy may increase the risk of wearing-off and dyskinesia, but the events between the two groups may not be different in the long term.
JOURNAL OF NEUROLOGY
(2022)
Review
Health Care Sciences & Services
Daniel van Poppelen, Annelie N. M. Tromp, Rob M. A. de Bie, Joke M. Dijk
Summary: Based on a retrospective case series and literature review, it was found that patients with Parkinson's disease who have persisting medication related motor response fluctuations despite DBS or CLI treatment may benefit from an additional or alternative treatment with either CLI or DBS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Annalisa Gessani, Francesco Cavallieri, Valentina Fioravanti, Isabella Campanini, Andrea Merlo, Giulia Di Rauso, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Alessandro Fraternali, Annibale Versari, Giuseppe Biagini, Valerie Fraix, Serge Pinto, Elena Moro, Carla Budriesi, Franco Valzania
Summary: This study aimed to evaluate the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on speech in advanced Parkinson's Disease (PD) patients. The results showed that speech intelligibility stayed at the same level as preoperative values in the long-term follow-up. However, there was a significant acute improvement of speech intelligibility in the postoperative assessment.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Bruno L. Santos-Lobato, Luiz Gustavo Gardinassi, Mariza Bortolanza, Ana Paula Ferranti Peti, Angela V. Pimentel, Lucia Helena Faccioli, Elaine A. Del-Bel, Vitor Tumas
Summary: Metabolomic analysis revealed a distinct metabolic profile associated with levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), particularly characterized by dysregulation of the glycosphingolipid metabolic pathway and bile acid biosynthesis metabolites in plasma and CSF. These findings suggest a potential link between lipid metabolism dysregulation and LID in PD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Miranda J. Munoz, James L. Reilly, Gian D. Pal, Leo Verhagen Metman, Yessenia M. Rivera, Quentin H. Drane, Daniel M. Corcos, Fabian J. David, Lisa C. Goelz
Summary: This study examined the effect of anti-Parkinsonian medication on visually-guided saccades (VGS) and found inconsistent findings in previous research. The use of different paradigms or target eccentricities may have contributed to these inconsistencies. Medication had adverse effects on saccade latency, gain, and peak velocity, and did not provide therapeutic benefits.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
R. Garcia-Ramos, D. Santos-Garcia, A. Alonso-Canovas, M. Alvarez-Sauco, B. Ares, A. Avila, N. Caballol, F. Carrillo, F. Escamilla Sevilla, E. Freire, J. C. Gomez Esteban, I Legarda, L. Lopez Manzanares, E. Lopez Valdes, I Martinez-Torres, M. Mata, I Parees, B. Pascual-Sedano, P. Mir, J. C. Martinez Castrillo
Summary: Parkinson's disease in women of childbearing age poses challenges in managing symptoms and medications during pregnancy and breastfeeding. Clinical characteristics, factors affecting their lives, and guidelines for pregnancy management were discussed by a group of experts, highlighting the need for a multi-disciplinary approach to address all relevant considerations.
Article
Clinical Neurology
W. R. Wayne Martin, Michael Miles, Qiaonan Zhong, Johanna Hartlein, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Baijayanta Maiti, Susan Criswell, Albert A. Davis, Paul T. Kotzbauer, Nigel J. Cairns, Richard J. Perrin, Joel S. Perlmutter
Summary: A significant response to dopaminergic therapy is common but not universal in Parkinson's disease (PD). Lack of response does not necessarily exclude PD. In other neurodegenerative disorders associated with parkinsonism, a prominent therapeutic response may also be present, but less frequently than in PD.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Xiaoqin He, Chengjun Mo, Yi Zhang, Ying Cai, Xiaodong Yang, Yiwei Qian, Qin Xiao
Summary: This study investigated the effect of acute levodopa up-titration on blood pressure in patients with early stage PD. The results showed that acute levodopa up-titration does not exacerbate the blood pressure reduction induced by anti-PD drugs, and blood pressure monitoring is critical for the management of PD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)