Review
Clinical Neurology
Han-Joon Kim, Beomseok Jeon
Summary: Deep brain stimulation (DBS) is an effective and safe treatment for certain types of dystonia, providing significant clinical improvement in patients who do not respond well to other treatments. However, further research is needed to evaluate the efficacy of DBS in other types of dystonia.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Review
Neurosciences
Ana Carolina P. Campos, Rosana L. Pagano, Nir Lipsman, Clement Hamani
Summary: Treatment-resistant depression (TRD) affects millions of individuals worldwide and deep brain stimulation (DBS) has been proposed as an adjuvant therapy for TRD. The antidepressant efficacy of DBS is still controversial, and its mechanisms of action remain poorly understood. Astrocytes, which play a major role in brain homeostasis, neuroinflammation, and neuroplasticity, may be pivotal in understanding the effects of DBS on TRD.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Marco Prenassi, Linda Borellini, Tommaso Bocci, Elisa Scola, Sergio Barbieri, Alberto Priori, Roberta Ferrucci, Filippo Cogiamanian, Marco Locatelli, Paolo Rampini, Maurizio Vergari, Stefano Pastore, Bianca Datola, Sara Marceglia
Summary: The presence of post-surgery edema after deep brain stimulation implantation in Parkinson's disease patients is correlated with the quality of local field potential recordings, particularly with the localization of the edema.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Vincenzo Levi, Giovanna Zorzi, Giuseppe Messina, Luigi Romito, Irene Tramacere, Ivano Dones, Nardo Nardocci, Angelo Franzini
Summary: Both deep brain stimulation (DBS) and pallidotomy are safe and effective treatments for drug-resistant status dystonicus, with high success rates. The choice between the two techniques should be individualized based on patient-specific factors.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Joshua K. K. Wong, Helen S. S. Mayberg, Doris D. D. Wang, R. Mark Richardson, Casey H. H. Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro'ee Gilron, James F. F. Cavanagh, Jack W. W. Judy, Svjetlana Miocinovic, Annaelle D. D. Devergnas, Roy V. V. Sillitoe, Stephanie Cernera, Carina R. R. Oehrn, Aysegul Gunduz, Wayne K. K. Goodman, Erika A. A. Petersen, Helen Bronte-Stewart, Robert S. S. Raike, Mahsa Malekmohammadi, David Greene, Petra Heiden, Huiling Tan, Jens Volkmann, Valerie Voon, Luming Li, Pankaj Sah, Terry Coyne, Peter A. A. Silburn, Cynthia S. S. Kubu, Anna Wexler, Jennifer Chandler, Nicole R. R. Provenza, Sarah R. R. Heilbronner, Marta San Luciano, Christopher J. J. Rozell, Michael D. D. Fox, Coralie de Hemptinne, Jaimie M. M. Henderson, Sameer A. A. Sheth, Michael S. S. Okun
Summary: The Deep Brain Stimulation (DBS) Think Tank X was held in Orlando FL on August 17-19, 2022, with the theme of women in neuromodulation. Dr. Helen Mayberg, the keynote speaker, discussed the development of DBS for depression. The consensus among the speakers was that DBS has expanded in scope but certain indications have faced challenges.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Francesco Sammartino, Paul Taylor, Gang Chen, Richard C. Reynolds, Daniel Glen, Vibhor Krishna
Summary: The study demonstrated the feasibility of acquiring reliable and responsive fMRI signals during asleep DBS surgery. The fMRI signals were sensitive to the changes in neural oscillations network connectivity caused by the insertion of the cannula.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Carolina Candeias da Silva, Wilson Fung, Mojgan Hodaie, Alfonso Fasano
Summary: Cervical dystonia is a common adult-onset focal dystonia that can affect sleep quality. Deep brain stimulation (DBS) is an effective treatment for cervical dystonia, although its impact on sleep is not well understood. We present a case of an unusual form of insomnia in a patient with cervical dystonia following DBS surgery, which resolved after surgical revision of the extension wire.
Article
Clinical Neurology
Jan Roediger, Till A. Dembek, Gregor Wenzel, Konstantin Butenko, Andrea A. Kuehn, Andreas Horn
Summary: A data-driven model was developed to suggest optimal stimulation parameters for Parkinson's disease patients undergoing deep brain stimulation treatment, improving motor outcomes while minimizing the risk of side effects caused by stimulation. This approach may provide guidance for future DBS programming.
MOVEMENT DISORDERS
(2022)
Review
Medicine, Research & Experimental
Oskar Puk, Magdalena Jablonska, Pawel Sokal
Summary: This systematic review consolidates findings on the immunological and endocrine effects of Deep Brain Stimulation (DBS) and Spinal Cord Stimulation (SCS), revealing that both these neurostimulation techniques have anti-inflammatory effects by modulating local immune responses. These findings provide a foundation for future research in this field.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Wenhao Wu, Jun Zhou, Panling Huang, Chunyang Pan, Zhixiang Huang, Changfeng Xu
Summary: This paper investigates the influence of longitudinal vibration on friction force during needle insertion, and experiments show that vibration can change friction force by affecting the equivalent friction coefficient and the positive pressure of tissue against the needle.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Gunther Deuschl, Jens Volkmann, Andrea A. Kuhn
Summary: This study retrospectively investigated the clinical results of deep brain stimulation (DBS) for cervical and generalized dystonia in 80 patients. The researchers modeled the optimal stimulation sites based on imaging and found that the optimal treatment for cervical dystonia involved modulation of the striatopallidofugal axis, while pallidothalamic bundles were responsible for optimal treatment of generalized dystonia. Additionally, the study showed a common network substrate in the form of connectivity to the cerebellum and somatomotor cortex for both types of dystonia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Geriatrics & Gerontology
Markey C. Olson, Holly Shill, Francisco Ponce, Sana Aslam
Summary: This systematic review aims to investigate the complications and risk of hospitalization following deep brain stimulation (DBS) surgery, and it is found that when candidates are carefully screened, DBS is a relatively low-risk procedure, but the hospitalization rate is somewhat increased for DBS patients. Further research is needed to determine the relative influence of more advanced disease vs. DBS itself in the increased rate of hospitalization.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Roxanne Lofredi, Cem-Georg Auernig, Siobhan Ewert, Friederike Irmen, Leon A. Steiner, Ute Scheller, Bernadette C. M. van Wijk, Simon Oxenford, Andrea A. Kuhn, Andreas Horn
Summary: Lead-DBS is a reliable and easy-to-use software tool for precise localization of deep brain stimulation electrodes. This study investigates the differences introduced by different raters and imaging types in the manual refinement process of electrode localization using Lead-DBS. The results show similar outcomes for all users, with an increase in variability when using postoperative MRI and standard space normalization. These findings contribute to the understanding of Lead-DBS and its potential use in formal training and imaging research in the field of deep brain stimulation.
Review
Neurosciences
Stefanie Perl, Anika Luettig, Rudiger Koehling, Angelika Richter
Summary: This review provides an overview of DBS research in animal models of dystonia, discussing the research aims, opportunities and limitations of different animal models, and technical challenges.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Kanwaljeet Garg, Manmohan Singh, Raghu Samala, Roopa Rajan, Sheffali Gulati, Vinay Goyal
Summary: Bilateral pallidotomy may lead to clinically significant improvement in children with acquired/heredo-degenerative generalized dystonia, although the benefits should be carefully assessed against the risk of permanent bulbar dysfunction. It is a viable option for children in resource-limited settings.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Alina Sprenger-Svacina, Johannes Haensch, Kilian Weiss, Nils Grosse Hokamp, David Maintz, Marc Schlamann, Gereon R. Fink, Natalie Schloss, Kai Laukamp, Gilbert Wunderlich, Helmar C. Lehmann, Thorsten Lichtenstein
Summary: This study evaluated the utility of a multi-parametric MRI protocol to detect loss of spinal motor neurons and subsequent muscle damage in adult SMA patients. The results showed that water T-2 mapping and Dixon-based PDFF estimation can distinguish between SMA patients and controls.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Martin K. R. Svacina, Alina Sprenger-Svacina, Anastasia Tsakmaklis, Alina M. Rueb, Ines Klein, Hauke Wuestenberg, Gereon R. Fink, Helmar C. Lehmann, Maria J. G. T. Vehreschild, Fedja Farowski
Summary: This study found that the gut microbiome of CIDP patients has increased diversity and enrichment of Firmicutes, which produce short-chain fatty acids. However, intravenous immunoglobulin (IVIg) administration did not have a short-term impact on the gut microbiome in CIDP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Serge Pinto, Adelheid Nebel, Jorn Rau, Robert Espesser, Pauline Maillochon, Oliver Niebuhr, Paul Krack, Tatiana Witjas, Alain Ghio, Marie-Charlotte Cuartero, Lars Timmermann, Alfons Schnitzler, Helke Hesekamp, Niklaus Meier, Julia Muellner, Thomas D. Haelbig, Bettina Moeller, Steffen Paschen, Laura Paschen, Jens Volkmann, Michael T. Barbe, Gereon R. Fink, Johannes Becker, Paul Reker, Andrea A. Kuehn, Gerd-Helge Schneider, Valerie Fraix, Eric Seigneuret, Andrea Kistner, Olivier Rascol, Christine Brefel-Courbon, Fabienne Ory-Magne, Christian J. Hartmann, Lars Wojtecki, Anne Fradet, David Maltete, Philippe Damier, Severine Le Dily, Friederike Sixel-Doering, Petra Benecke, Daniel Weiss, Tobias Waechter, Marcus O. Pinsker, Jean Regis, Stephane Thobois, Gustavo Polo, Jean-Luc Houeto, Andreas Hartmann, Karina Knudsen, Marie Vidailhet, Michael Schuepbach, Gunther Deuschl
Summary: This study compared speech intelligibility assessment and other outcomes between subthalamic nucleus deep brain stimulation (STN-DBS) and best medical treatment (BMT) in early-stage Parkinson's disease patients over a 2-year period. The results showed no significant differences in speech intelligibility and patient-reported outcomes between the STN-DBS and BMT groups, but there was a trend towards worsening in both groups.
MOVEMENT DISORDERS
(2023)
Article
Neuroimaging
Nina N. Kleineberg, Claudia C. Schmidt, Monika K. Richter, Katharina Bolte, Natalie Schloss, Gereon R. Fink, Peter H. Weiss
Summary: Previous studies on left hemisphere stroke patients found effector-specific differences in imitation performance and differences between meaningless and meaningful gestures. The current study investigated the impact of gesture meaning on lesion correlates of effector-specific imitation deficits in a large sample of sub-acute left hemisphere stroke patients. The results revealed significant interactions between the effector used for imitation and the meaning of the imitated gesture. Lesion-symptom mapping analyses identified brain regions associated with impaired imitation, regardless of the effector or gesture meaning. The findings highlight the importance of considering gesture meaning in assessments of apraxia.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Francesco Cavallieri, Annalisa Gessani, Andrea Merlo, Isabella Campanini, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Valerie Fraix, Sara Meoni, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Serge Pinto, Elena Moro, Franco Valzania
Summary: This study evaluates correlations between speech and gait parameters in advanced Parkinson's disease patients under different medication and subthalamic nucleus deep brain stimulation conditions. The results show that patients who spoke louder had greater trunk acceleration during gait, and patients with poorer voice quality performed worse in the sit to stand and gait phases of the iTUG. Conversely, patients with higher speech rate performed well in the turning and walking phases of the iTUG.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Jessica Rossi, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Sara Meoni, Valerie Fraix, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Andrea Merlo, Elena Moro, Franco Valzania
Summary: This study assessed the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on gait in advanced Parkinson's Disease (PD) patients. The results showed that in the long-term after surgery, STN-DBS can contribute to gait and postural control improvement when used together with dopamine replacement therapy.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Cristina Simonet, Philipp Mahlknecht, Kathrin Marini, Klaus Seppi, Aneet Gill, Jonathan P. Bestwick, Andrew J. Lees, Gavin Giovannoni, Anette Schrag, Alastair J. Noyce
Summary: The PREDICT-PD study utilized a risk algorithm to stratify individuals for future Parkinson's disease and found an association between risk scores and sub-threshold parkinsonism. The algorithm was able to identify individuals with motor decline over time.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Andre Zacharia, Diego Kaski, Walid Bouthour, Viswas Dayal, Matthieu Bereau, Philipp Mahlknecht, Dejan Georgiev, Julie Peron, Tom Foltynie, Ludvic Zrinzo, Marjan Jahanshahi, John Rothwell, Patricia Limousin
Summary: This study investigated the effects of 80 Hz vs. 130 Hz frequency STN-DBS on eye movements and executive control in Parkinson's disease patients. The results showed that 80 Hz STN-DBS reduced the ability to maintain stable fixation, resulting in a higher antisaccade error rate, without affecting inhibition or motor state.
NPJ PARKINSONS DISEASE
(2023)
Correction
Health Policy & Services
Kim Dillen, Yasemin Goereci, Veronika Dunkl, Anne Muller, Gereon R. Fink, Raymond Voltz, Mevhibe Hocaoglu, Clemens Warnke, Heidrun Golla
PALLIATIVE & SUPPORTIVE CARE
(2023)
Article
Health Policy & Services
Kim Dillen, Yasemin Goereci, Veronika Dunkl, Anne Mueller, Gereon R. Fink, Raymond Voltz, Mevhibe Hocaoglu, Clemens Warnke, Heidrun Golla
Summary: This study culturally adapted and translated the IPOS Neuro-S8 into German and evaluated its face and content validity. The results showed that the German version of the IPOS Neuro-S8 has demonstrated face and content validity and captures relevant symptoms of neurological patients needing palliative care. The next step is to investigate its psychometric properties, including construct and criterion validity.
PALLIATIVE & SUPPORTIVE CARE
(2023)
Article
Oncology
Norbert Galldiks, Nathalie L. Albert, Michael Wollring, Jan-Michael Werner, Philipp Lohmann, Javier E. Villanueva-Meyer, Gereon R. Fink, Karl-Josef Langen, Joerg-Christian Tonn
Summary: In patients with meningioma, anatomical imaging using MRI or CT is the main method for diagnosis and treatment planning. However, these imaging modalities have limitations in accurately delineating meningioma, especially in cases of trans-osseus growth and tumors with complex geometry, as well as differentiating post-therapeutic changes from relapse. PET imaging, which provides metabolic and cellular information, is being increasingly used to complement anatomical imaging and improve the clinical management of meningioma patients.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Clinical Neurology
Theresa Paul, Valerie M. Wiemer, Lukas Hensel, Matthew Cieslak, Caroline Tscherpel, Christian Grefkes, Scott T. Grafton, Gereon R. Fink, Lukas J. Volz
Summary: This study used diffusion spectrum imaging (DSI) and a novel compartment-wise analysis approach to investigate the structural connectivity between bilateral cortical core motor regions in chronic stroke patients. The results showed that the structural connectivity between these regions is associated with both basal and complex motor control. Specifically, the recovery of basal motor control may be supported by an alternative pathway through the contralesional primary motor cortex (M1) and non-crossing fibers of the contralesional corticospinal tract (CST). These findings help explain conflicting interpretations of the functional role of the contralesional M1 and suggest the potential of cortico-cortical structural connectivity as a biomarker for motor recovery post-stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Johannes L. Busch, Jonathan Kaplan, Bahne H. Bahners, Jan Roediger, Katharina Faust, Gerd-Helge Schneider, Esther Florin, Alfons Schnitzler, Patricia Krause, Andrea A. Kuehn
Summary: Stimulation-induced beta power suppression is superior to directional beta power in selecting the most effective contact for programming deep brain stimulation systems in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Joshua N. Strelow, Till A. Dembek, Juan C. Baldermann, Pablo Andrade, Gereon R. Fink, Veerle Visser-Vandewalle, Michael T. Barbe
Summary: This study aimed to assess the utility of low beta-band suppression as a tool for contact selection in STN-DBS for PD. The results showed that the degree of low beta-band suppression correlated with the clinical efficacy of the respective stimulation contact, indicating its potential as a reliable tool for contact selection in STN-DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Lukas Hensel, Aline Seger, Ezequiel Farrher, Anna K. Bonkhoff, N. Jon Shah, Gereon R. Fink, Christian Grefkes, Michael Sommerauer, Christopher E. J. Doppler
Summary: This study found that the motor response in Parkinson's disease patients is related to the temporal dynamics of corticostriatal functional connectivity. Patients with high response spent more time in a regionally integrated state, while low responders showed lower functional connectivity between the anterior midcingulate cortex/dorsal anterior cingulate cortex and putamen during a more segregated state, which was correlated with the motor response.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)