Article
Oncology
Kjetil Soreide, Elena Rangelova, Christina Dopazo, Sven Mieog, Stefan Staettner
Summary: The need for a standardized education and training track in surgical oncology across Europe is emphasized. ESSO offers hands-on courses and face-to-face discussions for skills training. The UEMS/EBSQ fellowship exam tests core competencies in candidates' specialized areas of expertise, but lacks a standardized set of points for each cancer type. This article outlines pancreatic cancer as part of an optimal practice in surgical oncology.
Article
Surgery
Hannah R. Shrader, Ann M. Miller, Ann Tomanek-Chalkley, Ashley McCarthy, Kristen L. Coleman, Po Hien Ear, Ashutosh K. Mangalam, Aliasger K. Salem, Carlos H. F. Chan
Summary: The study found that alteration of bile microbiome from biliary stenting has a direct impact on pancreatic cancer cell survival, with some contaminated bile even weakening the anti-tumor effect. In addition, conjugated bile acids were more potent than unconjugated ones in reducing pancreatic cancer cell survival.
Article
Oncology
Mohamed Abdelgadir Adam, Ibrahim Nassour, Richard Hoehn, Callie A. Hlavin, Nathan Bahary, David L. Bartlett, Kenneth K. W. Lee, Amer H. Zureikat, Alessandro Paniccia
Summary: This study found that the use of neoadjuvant chemotherapy (NAC) can compensate for the survival disadvantage caused by omission of adjuvant chemotherapy (AC) for resected pancreatic adenocarcinoma patients. NAC is associated with improved overall survival for patients who did not receive AC, and the median overall survival for these patients is comparable to those who received AC alone.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Marsha Reyngold, Eileen M. O'Reilly, Anna M. Varghese, Megan Fiasconaro, Melissa Zinovoy, Paul B. Romesser, Abraham Wu, Carla Hajj, John J. Cuaron, Richard Tuli, Lara Hilal, Danny Khalil, Wungki Park, Ellen D. Yorke, Zhigang Zhang, Kenneth H. Yu, Christopher H. Crane
Summary: Ablative radiation therapy following multiagent induction therapy for locally advanced pancreatic cancer is associated with durable locoregional tumor control and favorable survival outcomes. Prospective randomized trials in patients with inoperable LAPC are warranted.
Article
Oncology
Lingdi Yin, Ning Pu, Elizabeth Thompson, Yi Miao, Christopher Wolfgang, Jun Yu
Summary: The study revealed that somatic mutations, CTCs, and ctDNA still exist in patients with PDAC who achieved pCR after NAT, potentially indicating early recurrence and reduced survival. The current regression evaluation system of PDAC needs to be reassessed at a molecular level.
CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jillian W. Bonaroti, Mazen S. Zenati, Amr I. Al-abbas, Caroline J. Rieser, Amer H. Zureikat, Melissa E. Hogg, Herbert J. Zeh, Brian A. Boone
Summary: The study on POP patients after pancreatic resection revealed that patients with grade C POP had a significantly decreased overall survival and were less likely to receive adjuvant chemotherapy, further contributing to a decrease in survival time.
Review
Oncology
Stefano Crippa, Claudio Ricci, Giovanni Guarneri, Carlo Ingaldi, Giulia Gasparini, Stefano Partelli, Riccardo Casadei, Massimo Falconi
Summary: The oncological benefit of achieving a negative pancreatic neck margin through re-resection after a positive frozen section (FS) is debated. Results suggest that a negative neck margin after primary resection or re-resection of a positive FS is associated with improved survival outcomes for patients with ductal adenocarcinoma.
Article
Gastroenterology & Hepatology
Jason B. Liu, Vernissia Tam, Mazen S. Zenati, Danielle Schwartz, Areej Ali, Carissa A. Low, Lillian J. Smith, Herbert J. Zeh III, Amer H. Zureikat, Melissa E. Hogg
Summary: Robotic-assisted pancreatectomy may offer greater improvement in symptoms from the patient's perspective compared to open surgery by three months postoperatively. However, patients who underwent robotic surgery experienced worse FACT-Hep scores, while showing significant improvement in the HCS scores. There was no significant change in the FACT-G scores.
Article
Oncology
Jeffrey Chen, Tess M. E. van Ramshorst, Sanne Lof, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando M. Burdio, Giovanni Butturini, Riccardo Casadei, Andrea Coratti, Mathieu D'Hondt, Safi Dokmak, Bjorn Edwin, Alessandro Esposito, Jean M. Fabre, Giovanni Ferrari, Fadhel S. Fteriche, Giuseppe K. Fusai, Bas Groot Koerkamp, Thilo Hackert, Asif Jah, Jin-Young Jang, Emanuele F. Kauffmann, Tobias Keck, Alberto Manzoni, Marco Marino, Quintus Molenaar, Elizabeth Pando, Patrick Pessaux, Andrea Pietrabissa, Zahir Soonawalla, Robert P. Sutcliffe, Lea Timmermann, Steven White, Vincent S. Yip, Alessandro Zerbi, Mohammad Abu Hilal, Marc G. Besselink
Summary: RDP and LDP provide comparable R0-resection rate and overall survival in experienced centers for patients with resectable pancreatic cancer. Although RDP appears to have favorable lymph node yield and conversion rate, LDP is associated with shorter operating time, less major complications, and shorter hospital stay. The specific benefits associated with each approach should be confirmed by multicenter, randomized trials.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Markus K. Diener, Andre L. Mihaljevic, Oliver Strobel, Martin Loos, Thomas Schmidt, Martin Schneider, Christoph Berchtold, Arianeb Mehrabi, Beat P. Mueller-Stich, Kuirong Jiang, John P. Neoptolemos, Thilo Hackert, Yi Miao, Markus W. Buechler
Summary: Periarterial divestment is a technique to clear periarterial soft tissue around peripancreatic visceral arteries during pancreatic surgery, which can prevent the need for arterial resection in borderline and locally advanced pancreatic cancer. It, together with other resection strategies like artery first maneuver and mesenterico-portal venous bypass first, enables tumor resection in locally advanced pancreatic cancer.
Article
Nutrition & Dietetics
Kalliopi-Anna Poulia, Dimitra Antoniadou, Panagiotis Sarantis, Michalis V. Karamouzis
Summary: This study aimed to evaluate the interrelation between nutritional parameters, QOL indicators, and survival outcomes in patients with pancreatic cancer. The results showed that nutritional risk was associated with age, dynamometry, and financial difficulties. Increased fatigue, higher prevalence of constipation, and increased reporting of gastrointestinal problems were all linked to lower survival. These findings highlight the importance of early identification and management of symptoms and nutritional status in pancreatic cancer patients.
Article
Oncology
Asmita Chopra, Mazen Zenati, Melissa E. Hogg, Herbert J. Zeh, David L. Bartlett, Nathan Bahary, Amer H. Zureikat, Joal D. Beane
Summary: The study found that R0 resection is an important factor affecting overall survival and disease-free survival, even when neoadjuvant therapy is administered. For patients with R1 resection, receiving neoadjuvant therapy may prolong disease-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Rebecca Y. Kim, Kathleen K. Christians, Mohammed Aldakkak, Callisia N. Clarke, Ben George, Mandana Kamgar, Abdul H. Khan, Naveen Kulkarni, William A. Hall, Beth A. Erickson, Douglas B. Evans, Susan Tsai
Summary: The study found that total neoadjuvant therapy (TNT) can ensure the delivery of intended systemic therapy before a complicated operation without decreasing the chance of successful surgery. Patients who can tolerate shorter course neoadjuvant therapy (SNT) may also benefit from total neoadjuvant therapy (TNT).
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Surgery
Yibo Fu, Jiangdong Qiu, Yiqi Yu, Danning Wu, Taiping Zhang
Summary: A comparison between robotic pancreaticoduodenectomy (RPD) and open pancreaticoduodenectomy (OPD) showed that RPD is safer with better perioperative outcomes and lower blood loss. However, in terms of oncological outcomes, RPD does not have an advantage over OPD, and it is also more expensive.
FRONTIERS IN SURGERY
(2022)
Article
Multidisciplinary Sciences
Ryoichi Miyamoto, Amane Takahashi, Aya Ogasawara, Toshiro Ogura, Kei Kitamura, Hiroyuki Ishida, Shinichi Matsudaira, Satoshi Nozu, Yoshiyuki Kawashima
Summary: This study evaluates the performance of the SYNAPSE VINCENT (R) AI engine in the semi-automated surgical simulation of the pancreatic parenchyma, pancreatic ducts, and peripancreatic vessels. The results show that the AI engine is able to extract these structures effectively, indicating its potential usefulness in pancreatic surgery simulation.