Article
Immunology
Zhi Lu, Yiqun Yao, Jinhong Wang, J-Y Peng
Summary: Dioscin exhibits protective effects on diabetes cognitive dysfunction by regulating the P2X7R/NLRP3 signal pathway, indicating its potential value in preventing type 2 diabetes cognitive dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Alexander Jackson, Eryn L. Werry, James O'Brien-Brown, Paolo Schiavini, Shane Wilkinson, Erick C. N. Wong, Andre D. J. McKenzie, Alexandra Maximova, Michael Kassiou
Summary: Antagonists of the P2X7 receptor have therapeutic potential for diseases involving neuroinflammation. A recently developed structural hybrid compound showed insights into the interaction of antagonists with the P2X7R. LL-37 was found to enhance the ability of ATP to induce dye uptake.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Immunology
Jean M. Kanellopoulos, Cassio Luiz Coutinho Almeida-da-Silva, Sirje Ruutel Boudinot, David M. Ojcius
Summary: Extracellular nucleotides mediate activation through P2 and P1 receptors, with P2X4 receptor responding to ATP in lysosomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jahirul Islam, Jung-Ah Cho, Ju-Yong Kim, Kyung-Sun Park, Young-Jae Koh, Chu Young Chung, Eun-Jae Lee, Soo Jeong Nam, Kyoungyul Lee, Seoung-Heon Kim, Sung-Hye Park, Dong Young Lee, Byeong C. Kim, Kyung-Hwa Lee, Seung-Yong Seong
Summary: This study demonstrates that inhibiting the activation of N3I by targeting P2X7R with taurodeoxycholate (TDCA), a GPCR19 ligand, can alleviate neuroinflammation in Alzheimer's disease (AD). TDCA reduces the number of A beta plaques, enhances A beta phagocytosis, and improves pathological and cognitive functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhang, Weiguo Huang, Qikuan He, Tuo Deng, Boda Wu, Feifei Huang, Jiayang Bi, Yuepeng Jin, Hongwei Sun, Qiyu Zhang, Keqing Shi
Summary: This study demonstrated that mitophagy plays a crucial role in the pathogenesis of acute pancreatitis, with impaired mitophagy in severe acute pancreatitis. PINK1-/- and PARK2-/- mice were more sensitive to the onset of SAP, and deficiency in mitophagy could lead to the formation of NLRP3 inflammasome.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Environmental Sciences
Xiang Zeng, Dongling Liu, Weidong Wu, Xia Huo
Summary: This article explores the mechanism by which fine particulate matter (PM2.5) affects the NLRP3 inflammasome, highlighting the potential role of ATP changes in triggering NLRP3 inflammasome activation. Investigating ATP changes due to exposure to PM2.5 may be crucial in regulating NLRP3 inflammasome activation and treating inflammation-related diseases, such as COVID-19.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sonia Missiroli, Mariasole Perrone, Roberta Gafa, Francesco Nicoli, Massimo Bonora, Giampaolo Morciano, Caterina Boncompagni, Saverio Marchi, Magdalena Lebiedzinska-Arciszewska, Bianca Vezzani, Giovanni Lanza, Franz Kricek, Alessandro Borghi, Francesco Fiorica, Keisuke Ito, Mariusz R. Wieckowski, Francesco Di Virgilio, Luigi Abelli, Paolo Pinton, Carlotta Giorgi
Summary: Uncontrolled inflammatory response from the tumor microenvironment significantly contributes to cancer progression. A trimeric complex at the mitochondria-associated membranes, involving P2X7 receptor-NLRP3 inflammasome interaction, is regulated by the tumor suppressor PML. Downregulation of PML leads to an exacerbated immune response and boosted tumor growth. Mislocalization of PML results in uncontrolled NLRP3 activation and cytokine production, fueling cancer development and worsening prognosis in various human cancers. Mechanistic insights into the PML-P2X7R-NLRP3 axis provide new opportunities for targeted therapeutic approaches in human carcinogenesis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biotechnology & Applied Microbiology
Yanzhao Wei, Wei Li, Shuang Yang, Peng Zhong, Yingying Bi, Yanhong Tang
Summary: In recent years, it has been found that high-decibel noise is a risk factor for ischemic heart disease. This study explored the association between noise exposure and postinfarction cardiac remodeling, focusing on the activation of the NLRP3 inflammasome. The results showed a higher activation of the NLRP3 inflammasome in the noisy environment group, highlighting the importance of effective noise prevention in improving postinfarction prognosis.
Article
Immunology
Moumita Saha, Krishnendu Manna, Krishna Das Saha
Summary: This study investigated the role of melatonin (MLT) in amending high-fat diet-induced nonalcoholic steatohepatitis (NASH) in the murine liver. MLT administration reduced NASH indices and restored the hepatic morphology and other pathophysiological features. MLT suppressed inflammasome activation and P2X7R expression, and increased Nrf2 level, which may normalize antioxidant protein expression. MLT also repressed matrix metalloproteinases and increased TIMP-1 level, suggesting improvement in liver fibrosis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Yanqin Li, Xiaoqian Sun, Xiangning Liu, Junjun Li, Xuan Li, Gang Wang, Yizhou Liu, Xiangyu Lu, Lingwen Cui, Mingyan Shao, Yong Wang, Wei Wang, Chun Li
Summary: This study aimed to investigate the specific mechanism of Qishen granule (QSG) in inhibiting inflammation after acute myocardial ischemia (AMI). The results showed that QSG rescued cardiac function and reduced inflammation by inhibiting NLRP3 inflammasome activation. In addition, QSG reduced macrophage inflammasome activation via the P2X7R-NEK7-NLRP3 pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Neurosciences
Yanyun Wang, Liang Dong, Yun Zhang, Yixin Zhang, Guangcheng Qin, Dunke Zhang, Lixue Chen, Wei He, Jiying Zhou
Summary: Excessive use of headache treatments can lead to the development, progression, and exacerbation of medication overuse headache (MOH), characterized by central sensitization. This study investigates the impact of microglial activation and the P2X7R/NLRP3 signaling pathway on the pathogenesis of MOH. The results suggest that inhibiting microglial activation can reduce central sensitization caused by chronic treatment and may be a potential strategy for managing MOH.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yajuan Wang, Zhengming Shan, Lily Zhang, Shanghua Fan, Yanjie Zhou, Luyu Hu, Yue Wang, Weidong Li, Zheman Xiao
Summary: This study highlights the crucial role of P2X7 receptor (P2X7R) in migraine-related cognitive impairment and suggests it as a potential therapeutic target. Using a mouse model, researchers found that migraine attacks led to upregulation of P2X7R and activation of inflammatory and cell death pathways, resulting in gliosis, neuronal loss, and cognitive impairment. Additionally, pretreatment with the P2X7R antagonist Brilliant Blue G (BBG) prevented and alleviated these pathological changes.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Immunology
Xiaojuan Dai, Xuan Fang, Yuan Xia, Manyun Li, Xiaomei Li, Yiping Wang, Jinhui Tao, Xiangpei Li
Summary: The activation of P2X7R exacerbates the development of acute gouty arthritis, while its inhibitor has the opposite effect. Activation of P2X7R promotes the infiltration of neutrophils and macrophages and increases the secretion of inflammatory cytokines. Additionally, P2X7R regulates the ratio of Tregs/Th17 cells.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Lingyun Li, Qiang Liu, Chenyu Le, Hongchen Zhang, Wenfei Liu, Ye Gu, Jianfeng Yang, Xiaofeng Zhang
Summary: The early aseptic immune response plays a key role in the aggravation of acute pancreatitis (AP). Toll-like receptor (TLR) 2, an important member of the TLR family, is found to be significantly increased in AP patients. TLR2 deficiency reduces inflammation, infiltration of pancreatic neutrophils and macrophages, and expression of proinflammatory cytokines IL-113, IL-6, IL-17, and IL-18 in a mouse model of cerulein-induced AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Grace A. Ward, Robert P. P. Dalton III, Benjamin S. Meyer, Amy F. McLemore, Amy L. Aldrich, Nghi B. Lam, Alexis H. Onimus, Nicole D. Vincelette, Thu Le Trinh, Xianghong Chen, Alexandra R. Calescibetta, Sean M. Christiansen, Hsin-An Hou, Joseph O. Johnson, Kenneth L. Wright, Eric Padron, Erika A. Eksioglu, Alan F. List
Summary: Myelodysplastic Syndromes (MDSs) are characterized by innate immune activation and pyroptotic cell death driven by NLRP3 inflammasome. The release of oxidized mitochondrial DNA (ox-mtDNA) into the cytosol enhances the inflammatory response in healthy tissues via engagement with Toll-like receptor 9 (TLR9). Blocking the TLR9/ox-mtDNA axis may be a promising therapeutic strategy for MDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)