Article
Clinical Neurology
Holly Elser, Michelle Caunca, David H. Rehkopf, Wells Andres, Rebecca F. Gottesman, Scott E. Kasner, Kristine Yaffe, Andrea L. C. Schneider
Summary: The study found that the diagnosis and treatment rates of poststroke depression have been increasing among stroke patients over the years. Women have a higher diagnosis rate compared to men, while racial/ethnic minorities have a lower diagnosis rate. Furthermore, women and older patients are more likely to receive treatment.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Hon Sen Tan, Zach Frere, Vijay Krishnamoorthy, Tetsu Ohnuma, Karthik Raghunathan, Ashraf S. Habib
Summary: The utilization of gabapentinoids in gynecologic surgery is increasing and has been found to be associated with postoperative pulmonary complications, including respiratory failure, pneumonia, and need for ventilation.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Article
Pharmacology & Pharmacy
Daniel G. Whitney, Mark D. Peterson, Edward A. Hurvitz
Summary: This study investigated the opioid prescription patterns between adults with and without cerebral palsy (CP). The results showed that adults with CP were more likely to be prescribed opioids and for a longer duration, which may alter the risk-benefit balance of opioids.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Medicine, General & Internal
Yuanyuan Wang, Jens H. Bos, Catharina C. M. Schuiling-Veninga, H. Marike Boezen, Job F. M. van Boven, Bob Wilffert, Eelko Hak
Summary: The study found that there was a lower incidence of NPAEs among general population using varenicline compared to nicotine replacement therapy, while there was no significant difference in NPAEs incidence between COPD patients using varenicline and NRT.
Article
Psychiatry
Louis Jacob, Christina Jacob, Ai Koyanagi, Lee Smith, Josep Maria Haro, Jae Il Shin, Karel Kostev
Summary: A retrospective cohort study in Germany found an association between the diagnosis of factor V Leiden (FVL) and a higher incidence of depression over a 10-year period. More research is needed to confirm these findings in other settings.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Clinical
Deepiksana Keerthy, Joht Singh Chandan, Juste Abramovaite, Krishna Margadhamane Gokhale, Siddhartha Bandyopadhyay, Ed Day, Steven Marwaha, Matthew R. Broome, Krishnarajah Nirantharakumar, Clara Humpston
Summary: This study investigates the relationship between cannabis exposure and the risks of mental illness diagnoses or treatment and finds that cannabis exposure is associated with an increased risk of developing mental health disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Anesthesiology
P. Daliya, A. Adiamah, F. Roslan, E. Theophilidou, R. D. Knaggs, N. Levy, D. N. Lobo
Summary: The study identified poor prescribing practices, a lack of guidance, and formal training at individual institutions in England, highlighting opportunities for improvement in opioid-prescribing practices.
Article
Medicine, General & Internal
Beverly P. Bergman, Daniel F. Mackay, Jill P. Pell
Summary: The study found that the risk of cardiovascular disease in Scottish military veterans has decreased from 23% to 16% overall in the five years following 2012 compared to people who had never served. The increased risk only affects veterans born before 1960, indicating that improvements in military health promotion have had a positive long-term impact.
Article
Health Care Sciences & Services
Susan L. Calcaterra, Yingbo Lou, Rachel M. Everhart, Lindsey E. Fish, Rebecca Hanratty
Summary: This study examined the association between in-clinic opioid administration and opioid receipt at discharge as well as progression to chronic opioid use in urgent care patients. The results showed that patients who received in-clinic opioids were more likely to receive opioids at discharge and had a higher risk of progressing to chronic opioid use.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Naoaki Nishimura, Haruhisa Fukuda
Summary: This study suggests that S. pneumoniae infection increases the risk of subsequent stroke and atrial fibrillation (AF), indicating that pneumococcal infections have short-term effects on patients' health and increase their susceptibility to serious cardiovascular events in the midterm to long term.
Article
Anesthesiology
Parker Nann, Noushin Nabavi, Kimia Ziafat, Roanne Preston, Anthony Chau, Michael R. Krausz, Stephan K. W. Schwarz, Malcolm Maclure
Summary: Postdischarge opioid prescriptions after abdominal and orthopedic surgeries have been increasing in British Columbia. Higher dosage opioids are being prescribed more frequently.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Oncology
Yara Sakr, Omar Hamdy, Maher Eldeghedi, Rabab Abdelaziz, Echreiva Med Sidi El Moctar, Mohammed Alharazin, Shadi Awny
Summary: Tongue cancer typically has male predominance. However, recent studies have shown an increasing number of cases among younger individuals, particularly females. This shift in global epidemiological trends requires further investigation. Our study confirms the higher incidence of tongue cancer in younger age groups but did not find significant changes in gender distribution in our locality. More multi-institutional studies are needed to understand these changes and identify potential risk factors.
Article
Public, Environmental & Occupational Health
Emelie Thern, Nuria Matilla-Santander, Julio C. Hernando-Rodriguez, Melody Almroth, Theo Bodin
Summary: Precarious employment in early adulthood is associated with an increased risk of later mental health problems requiring inpatient care, especially for males, according to a Swedish study.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Medicine, General & Internal
Monique M. Hedderson, Maryam M. Asgari, Fei Xu, Charles P. Quesenberry, Sneha Sridhar, Jamie Geier, Adina R. Lemeshow
Summary: This study evaluated and compared the incidence rates of malignancies in patients with moderate to severe atopic dermatitis (AD). The study found that patients with moderate to severe AD had higher incidence rates of malignancies, especially non-melanoma skin cancer and breast cancer.
Article
Clinical Neurology
Markku Lahteenvuo, Heidi Taipale, Antti Tanskanen, Saara Rannanpaa, Jari Tiihonen
Summary: This study investigated the incidence, risk factors, and courses of treatment for treatment-resistant depression (TRD). The findings suggest that antidepressant monotherapies are still the most common fifth line of depression treatment. Factors such as severe depression, hospitalization due to depression, young age, and male gender may predispose individuals to TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Eric B. Elbogen, John E. Zeber, Dawne Vogt, Daniel F. Perkins, Erin P. Finley, Laurel A. Copeland
Summary: This study examined the financial status and the difficulties in adjusting to civilian life among veterans. It found that financial satisfaction and functioning were influenced by psychosocial factors. The study emphasized the importance of assessing veterans' financial status, encouraging pursuit of a college degree, and improving household financial management to increase veterans' ability to manage their finances and achieve overall well-being after separation.
Article
Psychology, Clinical
Laurel A. Copeland, Erin P. Finley, Miriam L. Rubin, Daniel F. Perkins, Dawne S. Vogt
Summary: This study examines the trajectory and factors influencing the onset of PTSD symptoms during the military-to-civilian transition. The findings suggest that ongoing social support and psychological resilience can mitigate symptom severity, while current stress, female gender, and minority race/ethnicity are associated with an increased risk of PTSD symptoms.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Biochemistry & Molecular Biology
Nathaniel S. Thomas, Jessica E. Salvatore, Sally I-Chun Kuo, Fazil Aliev, Vivia V. McCutcheon, Jacquelyn M. Meyers, Kathleen K. Bucholz, Sarah J. Brislin, Grace Chan, Howard J. Edenberg, Chella Kamarajan, John R. Kramer, Samuel Kuperman, Gayathri Pandey, Martin H. Plawecki, Marc A. Schuckit, Danielle M. Dick
Summary: This study tested whether the childhood/adolescent home environment mediates genetic risk for alcohol problems across generations within families. The results showed that parental relationship discord and divorce partially mediated the transmission of genetic risk for alcohol problems from parents to children, predicting earlier ages of regular drinking, intoxication, greater lifetime maximum drinks, and more lifetime AUD criteria in European ancestry families. However, there was no evidence of indirect effects of parental alleles via relationship discord or divorce on offspring alcohol outcomes in African ancestry families.
MOLECULAR PSYCHIATRY
(2023)
Letter
Anesthesiology
Timothy Chruciel, Patrick D. Quinn, Joanne Salas, Jeffrey F. Scherrer
Article
Substance Abuse
Gayathri Pandey, Sally I-Chun Kuo, Kristina A. Horne-Osipenko, Ashwini K. Pandey, Chella Kamarajan, Stacey Saenz de Viteri, Sivan Kinreich, David B. Chorlian, Weipeng Kuang, Mallory Stephenson, John Kramer, Andrey Anokhin, Yong Zang, Samuel Kuperman, Victor Hesselbrock, Marc Schuckit, Danielle Dick, Grace Chan, Vivia V. McCutcheon, Howard Edenberg, Kathleen K. Bucholz, Jacquelyn L. Meyers, Bernice Porjesz
Summary: Parental closeness during adolescence is associated with neurocognitive functioning and alcohol use outcomes in high-risk offspring, with father's closeness being related to P3 amplitude and frontal theta power, and mother's closeness being related to binge drinking. Sex differences exist in these associations.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Marc A. Schuckit, Tom L. Smith, George Danko, Kathleen K. Bucholz, Victor Hesselbrock, Michie Hesselbrock, Samuel Kuperman, John Kramer, John I. Nurnberger, Dongbing Lai, Grace Chan, Chella Kamarajan, Sally Kuo, Danielle M. Dick, Jake Tear, Lee Anne Mendoza, Howard J. Edenberg, Bernice Porjesz
Summary: A study on 414 drinkers found that personality traits and levels of response to alcohol are associated with future alcohol problems, even after considering existing demographic and substance use variables. The results indicate that most personality traits and levels of response to alcohol can predict future alcohol problems.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Marc A. L. Schuckit, Tom L. Smith, George Danko, Jake Tear, Jessica Hennies, Lee Anne Mendoza, Victor J. Hesselbrock, Howard J. Edenberg, Michie Hesselbrock, Kathleen Bucholz, Grace Chan, Samuel W. Kuperman, Meredith W. H. Francis, Martin H. Plawecki
Summary: The study showed that the endorsement rates of alcohol dependence criteria generally increased among individuals in their twenties with persistent or recurrent AUD, while few changes were observed in the rates of endorsement of the abuse criteria. A similar pattern was seen within men, but women had significant changes in only some of the dependence criteria.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Sally I-Chun Kuo, Nathaniel S. S. Thomas, Fazil Aliev, Kathleen K. K. Bucholz, Danielle M. M. Dick, Vivia V. V. McCutcheon, Jacquelyn L. L. Meyers, Grace Chan, Chella Kamarajan, John R. R. Kramer, Victor Hesselbrock, Martin H. H. Plawecki, Bernice Porjesz, Jay Tischfield, Jessica E. E. Salvatore
Summary: This study aimed to test gene-by-environment interaction effects on alcohol outcomes, examining how children's genetic risk for alcohol problems modifies the impact of parental divorce and discord. The results showed that parental divorce, discord, and children's genetic risk were associated with earlier alcohol initiation and increased risk of alcohol use disorder. Furthermore, there were differences in the interaction effects across different ancestry groups.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Stacey Saenz de Viteri, Jian Zhang, Emma C. Johnson, Peter B. Barr, Howard J. Edenberg, Victor M. Hesselbrock, John I. I. Nurnberger Jr, Ashwini K. Pandey, Chella Kamarajan, Sivan Kinreich, Jay A. Tischfield, Martin H. Plawecki, John R. Kramer, Dongbing Lai, Samuel Kuperman, Grace Chan, Vivia V. McCutcheon, Kathleen K. Bucholz, Bernice Porjesz, Jacquelyn L. Meyers
Summary: Recent GWAS studies have identified genetic markers associated with post-traumatic stress disorder (PTSD) in civilian and military populations. However, the influence of co-occurring alcohol dependence on PTSD genetics has not been explored. This study examined genome-wide associations of PTSD and polygenic risk scores (PRS) for PTSD, derived from two different GWAS studies, with alcohol dependence and substance dependence. The findings highlight the importance of considering substance dependence, particularly alcohol dependence, when investigating the genetic factors underlying PTSD.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Chella Kamarajan, Ashwini K. Pandey, David B. Chorlian, Jacquelyn L. Meyers, Sivan Kinreich, Gayathri Pandey, Stacey Subbie-Saenz de Viteri, Jian Zhang, Weipeng Kuang, Peter B. Barr, Fazil Aliev, Andrey P. Anokhin, Martin H. Plawecki, Samuel Kuperman, Laura Almasy, Alison Merikangas, Sarah J. Brislin, Lance Bauer, Victor Hesselbrock, Grace Chan, John Kramer, Dongbing Lai, Sarah Hartz, Laura J. Bierut, Vivia V. McCutcheon, Kathleen K. Bucholz, Danielle M. Dick, Marc A. Schuckit, Howard J. Edenberg, Bernice Porjesz
Summary: This study investigates the use of multi domain features to classify individuals with and without alcohol-induced memory problems. Significant features include resting state brain connectivity, personality traits, life experiences, polygenic risk, and alcohol consumption and related consequences. These findings provide insights into predicting alcohol-related memory problems in later life.
BEHAVIORAL SCIENCES
(2023)
Review
Behavioral Sciences
Isabel Gameiro-Ros, Dina Popova, Iya P. Prytkova, Zhiping Pang, Yunlong Liu, Danielle K. Dick, Kathleen Bucholz, Arpana Agrawal, Bernice M. Porjesz, Alison Goate, Xiaoling Xuei, Chella A. Kamarajan, Jay J. Tischfield, Howard A. Edenberg, Paul P. Slesinger, Ronald Hart
Summary: Alcohol Use Disorder is a complex genetic disorder influenced by genetic, neural, and environmental factors. The Collaborative Study on the Genetics of Alcoholism (COGA) has identified potential risk genes using genome-wide association studies and investigated their functional changes using human cell lines and brain tissue. They have used high throughput reporter assays to identify single nucleotide polymorphisms affecting gene expression and modeled these genetic variants using induced pluripotent stem cells to evaluate their effects on neuronal physiology and response to ethanol. COGA has demonstrated the importance of integrating multimodal data and functional studies to understand the mechanisms underlying alcohol use disorder.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Geriatrics & Gerontology
Jay A. Brieler, Joanne Salas, Matthew E. Amick, Poorva Sheth, Elizabeth A. Keegan-Garrett, John E. Morley, Jeffrey F. Scherrer
Summary: The use of benzodiazepines in older patients is controversial. Anxiety disorders and benzodiazepines have been linked to dementia, but the literature is inconsistent. It is unclear whether treating anxiety with benzodiazepines, compared to anxiety disorder alone, is associated with an increased risk of dementia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Public, Environmental & Occupational Health
Joanne Salas, John E. Morley, Daniel F. Hoft, Jeffrey F. Scherrer
Summary: Receiving influenza, tetanus, diphtheria, and herpes zoster (HZ) vaccinations within 10 years of COVID-19 pandemic is associated with less severe COVID-19 infection. This study investigated if receiving two different vaccinations (HZ and tetanus, diphtheria, and pertussis (Tdap)) is associated with a lower risk for COVID-19 hospitalization. The findings suggest that receiving both HZ and Tdap vaccinations is associated with a lower risk of COVID-19 hospitalization.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Primary Health Care
Theresa Drallmeier, Joanne Salas, Elizabeth Keegan Garrett, Ashley Meyr, Jane Tucker, Jeffrey F. Scherrer
Summary: PrEP is under-utilized in primary care, and educational interventions are needed to increase knowledge and confidence among physicians to encourage prescribing.
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
(2023)
Article
Education & Educational Research
Daniel F. Perkins, Katie E. Davenport, Nicole R. Morgan, Keith R. Aronson, Julia A. Bleser, Kimberly J. McCarthy, Dawne Vogt, Erin P. Finley, Laurel A. Copeland, Cynthia L. Gilman
Summary: This study assessed the effectiveness of employment program components in increasing employability among military veterans during career and identity transitions. It identified several content and process components, such as interviewing skills and working with a mentor/coach, that influenced job attainment. Having a mentor/coach was found to be the most effective delivery strategy, leading to higher rates of job finding. Risk factors such as rank, combat exposure, combat arms occupation, and physical health problems were identified as predictors of lower use of employment program components.
INTERNATIONAL JOURNAL FOR EDUCATIONAL AND VOCATIONAL GUIDANCE
(2023)