Article
Medicine, Research & Experimental
Sheng Zhao, Wei Li, Weimin Yu, Ting Rao, Haoyong Li, Yuan Ruan, Run Yuan, Chenglong Li, Jinzhuo Ning, Siqi Li, Wu Chen, Fan Cheng, Xiangjun Zhou
Summary: Exosomal miR-21 from tubular epithelial cells accelerates renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys.
Article
Biochemistry & Molecular Biology
Rui Yu, Mi Tian, Ping He, Jie Chen, Zixia Zhao, Yongzhe Zhang, Beiru Zhang
Summary: LMCD1 plays a role in promoting tubulointerstitial fibrosis in chronic kidney disease. Silencing LMCD1 can alleviate renal fibrosis, prevent cell apoptosis and renal injury, and block the activation of ERK signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiangjun Zhou, Sheng Zhao, Wei Li, Yuan Ruan, Run Yuan, Jinzhuo Ning, Kun Jiang, Jinna Xie, Xiaobin Yao, Haoyong Li, Chenglong Li, Ting Rao, Weimin Yu, Fan Cheng
Summary: Unilateral ischemia reperfusion injury (UIRI) with longer ischemia time is associated with an increased risk of acute renal injury and chronic kidney disease. Exosomes play a key role in mediating communication between epithelial and mesenchymal cells relevant to renal fibrosis after UIRI. Inhibition of exosome secretion or miRNA activity could be a potential therapeutic target for preventing progression to renal fibrosis following UIRI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Ting Xie, Zunen Xia, Wei Wang, Xiangjun Zhou, Changgeng Xu
Summary: BMPER inhibits tubular dedifferentiation and fibroblast activation induced by TGF-beta 1, showing therapeutic potential for tubulointerstitial fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhirong Jia, Kaiwei Wang, Yameng Zhang, Yalei Duan, Kang Xiao, Shuo Liu, Xuansheng Ding
Summary: Icariin alleviates tubulointerstitial fibrosis by restoring autophagy through the miR-192-5p/GLP-1R pathway, offering a novel therapeutic option for diabetic fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Qiuer Liang, Tianhao Liu, Tingting Guo, Wencong Tao, Xudong Chen, Weihao Chen, Liguo Chen, Ya Xiao
Summary: The study showed that inhibiting ATF4 can improve renal damage and fibrosis in DN mice, as well as restore autophagy. In cell experiments, inhibition of ATF4 can increase autophagosome numbers, improve autophagic flux, and decrease Collagen type 4 (Col-IV) levels.
Article
Cell Biology
Shu Yang, Guangyan Yang, Xinyu Wang, Jiaqing Xiang, Lin Kang, Zhen Liang
Summary: This study demonstrates the anti-fibrotic role of SIRT2 in renal tubules and hepatocytes. SIRT2 inhibits fibrotic gene expression by reducing the activation of the TGF-beta signaling pathway. It interacts with and deacetylates SMAD2 and SMAD3 to promote their degradation and decrease the activation of SMAD3.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Heming Ma, Xiaomei Wang, Xu Liu, Chang Wang, Xiuzhu Gao, Junqi Niu
Summary: This study investigated the relationship between microRNA miR-654-5p and important nuclear receptor RXR alpha in liver fibrosis (LF) and found that miR-654-5p can inhibit RXR alpha expression, thereby promoting HSC and LX-2 cell proliferation and inhibiting apoptosis. In vivo experiments also confirmed that overexpression of miR-654-5p can worsen liver fibrosis in mice. These findings contribute to the understanding of the pathogenesis of LF and provide new potential targets for its treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaohong Sun, Haiming Xiao, Shanshan Li, Rui Chen, Zeyuan Lin, Yan Yang, Zhiquan Chen, Li Deng, Heqing Huang
Summary: This study reveals that Cx32 plays a protective role in diabetic renal tubulointerstitial fibrosis by suppressing EMT and ECM production, as well as inhibiting ROS generation in renal tubules. Mechanistically, Cx32 down-regulates PKCα expression to inhibit the formation of p22phox-NOX4 complex, leading to reduced NOX4 protein levels.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hua Fang, Weihua Wu, Zhijun Wu
Summary: This study revealed that the downregulation of miR-382-3p contributes to the carcinogenesis of lung adenocarcinoma (LA) by upregulating SAE1 and promoting AKT SUMOylation. This provides a potential target for the treatment of LA.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Cell Biology
Eun Young Kim, Stuart E. Dryer
Summary: TRPC6 channels are implicated in the development of kidney diseases, but their role in inflammation and fibrosis during aging is uncertain. Experimental findings suggest that the role of TRPC6 in the aging process does not have a significant protective effect on renal pathologies in rats.
Article
Pharmacology & Pharmacy
Jingran Zeng, Liyin Liang, Rui Chen, Chuting Li, Linjie Pan, Min Wen, Dongxin Lv, Min Liu, Zhanchi Xu, Heqing Huang
Summary: The study demonstrated that Fraxin could ameliorate renal tubulointerstitial fibrosis (RIF) in diabetic nephropathy by inhibiting epithelial-to-mesenchymal transition (EMT) and reducing collagen deposition. Furthermore, Fraxin directly bound to epidermal growth factor receptor (EGFR), leading to the inhibition of EGFR phosphorylation and the suppression of c-Src/NF-xB pathway activation, ultimately improving RIF. These findings suggest that Fraxin may be a potential drug candidate for treating diabetic nephropathy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Yan Lin, Fangfang Cai, Xiaoyang Wang, Yunwen Yang, Yongzhe Ren, Chun Yao, Xiaoxing Yin, Hongqin Zhuang, Zichun Hua
Summary: This study suggests that FADD may play a critical role in the development of renal fibrosis. Through various staining and immunofluorescence analysis, neutrophil infiltration, glomerular mesangial cell proliferation, and base-membrane thickening were observed in FADD-D mice. Macrophage infiltration was significantly enhanced, and the levels of renal fibrosis-related markers were elevated. Mechanism study indicates that FADD phosphorylation may activate the TLR4/myD88/NF-kappa B signaling pathway as well as the mTOR and TGF-beta/Smad pathway, accelerating the process of epithelial mesenchymal transition and eventually resulting in IgA nephritis and renal fibrosis.
Article
Pharmacology & Pharmacy
Yuzhan Zhang, Ke Li, Yan Li, Weihao Zhao, Li Wang, Zhao Chen, Xiaotao Ma, Tian Yao, Jinhua Wang, Wei Dong, Xiancheng Li, Xuefei Tian, Rongguo Fu
Summary: This study found increased expression of DPP8 and DPP9 in renal proximal tubule epithelial cells of CKD patients, and using a DPP8/DPP9 inhibitor significantly attenuated tubulointerstitial injury and improved renal function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ji-chao Wu, Xiao-jie Wang, Jing-han Zhu, Xue-ying Huang, Min Liu, Zhe Qiao, Yan Zhang, Yu Sun, Zi-ying Wang, Peng Zhan, Tao Zhang, Hui-li Hu, Hong Liu, Wei Tang, Fan Yi
Summary: This study found that GPR97 is significantly upregulated in hypertensive nephropathy and is involved in the development of tubulointerstitial fibrosis. GPR97(-/-) mice showed elevated blood pressure but reduced renal injury and fibrosis. Knockdown of GPR97 in cells inhibited TGF-beta signaling by disrupting RhoA-mediated cytoskeletal reorganization and clathrin-mediated endocytosis of TGF-beta receptors.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Multidisciplinary Sciences
Zhongmin Tian, Mingyu Liang
Summary: Hypertension is a major risk factor for global disease burden. The kidneys, with their high metabolic rate, are crucial in regulating blood pressure. Recent studies suggest that alterations in renal metabolism may play a significant role in the development of hypertension.
NATURE COMMUNICATIONS
(2021)
Review
Peripheral Vascular Disease
Mark K. Santillan, Richard C. Becker, David A. Calhoun, Allen W. Cowley, Joseph T. Flynn, Justin L. Grobe, Theodore A. Kotchen, Daniel T. Lackland, Kimberly K. Leslie, Mingyu Liang, David L. Mattson, Kevin E. Meyers, Mark M. Mitsnefes, Paul M. Muntner, Gary L. Pierce, Jennifer S. Pollock, Curt D. Sigmund, Stephen J. Thomas, Elaine M. Urbina, Srividya Kidambi
Summary: The American Heart Association awarded research funding for four hypertension-focused centers in 2015, emphasizing training for next-generation researchers and encouraging collaboration among the centers. Each center proposed integrated projects and the association sponsored postdoctoral fellows, while also providing leadership development opportunities.
Review
Peripheral Vascular Disease
Jing Liu, Yong Liu, Feng Wang, Mingyu Liang
Summary: miR-204 is a high-value microRNA that plays a critical role in regulating cardiovascular and renal physiology, exhibiting tissue-specific expression patterns and being influenced by multiple regulatory mechanisms. It attenuates pulmonary arterial hypertension and renal injury while promoting hypertension and endothelial dysfunction, potentially impacting disease processes through targeting various biological pathways. Dysregulation of miR-204 in cardiovascular and renal diseases highlights its unequivocal functional roles and clinical relevance.
Biographical-Item
Peripheral Vascular Disease
Allen W. Cowley, Srividya Kidambi, Mingyu Liang, Clarence Grim, Pavel Hamet
Article
Biotechnology & Applied Microbiology
David M. Jensen, Peng Han, Lingegowda S. Mangala, Gabriel Lopez-Berestein, Anil K. Sood, Jing Liu, Alison J. Kriegel, Kristie Usa, Michael E. Widlansky, Mingyu Liang
Summary: miR-29 promotes endothelial function in human arterioles by targeting LYPLA1 and increasing nitric oxide production, while also inhibiting extracellular matrix gene expression. Systemic delivery of low-dose miR-29b-CH-NP effectively treats cardiovascular and renal diseases in mice, showing promise in attenuating hypertension, fibrosis, and proteinuria.
Article
Cell Biology
Satoshi Shimada, Brian R. Hoffmann, Chun Yang, Theresa Kurth, Andrew S. Greene, Mingyu Liang, Ranjan K. Dash, Allen W. Cowley
Summary: In this study, novel methods were developed to measure arterial blood pressure and renal blood flow in freely moving rats and collect arterial and renal venous blood to estimate kidney metabolic fluxes. The effects of a high salt diet on kidney metabolism were determined using Sprague-Dawley rats. The study found significant changes in metabolomic and transcriptomic profiles, including increased expression of glycolysis-related genes in response to the high salt diet. The study provides evidence for the adaptation of kidney metabolism to a high salt diet.
Article
Biochemical Research Methods
Yifan Yang, Haoyuan Liu, Yi Liu, Liyuan Zhou, Xiaoqi Zheng, Rongxian Yue, David L. Mattson, Srividya Kidambi, Mingyu Liang, Pengyuan Liu, Xiaoqing Pan
Summary: DNA methylation plays a crucial role in transcriptional regulation. RRBS is a commonly used technique for analyzing genome-wide methylation profiles. This study proposes a method to calculate E-values for DMR detection in RRBS data, and provides a user-friendly interface to implement E-value calculations. The use of E-values significantly improves accuracy, area under ROC curve, power, false discovery rates and type I errors compared to P-values.
BRIEFINGS IN BIOINFORMATICS
(2023)