Article
Gastroenterology & Hepatology
Edoardo Vespa, Domenico A. Farina, Peter J. Kahrilas, Wenjun Kou, Eric E. Low, Rena Yadlapati, John E. Pandolfino, Dustin A. Carlson
Summary: This study found that patients with high PEP values on high-resolution manometry, high FLIP 60 mL pressures, and a spastic-reactive contractile response pattern on FLIP before treatment were more likely to experience post-treatment spasm. Evaluating these features may guide personalized patient management.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Morgane Sallette, Jamila Lenz, Francois Mion, Sabine Roman
Summary: This study compared the frequency of motility disorders diagnosed with CCv3.0 and CCv4.0 and evaluated the severity of symptoms. The results showed that while the diagnoses remained mainly unchanged with both versions, CCv4.0 had a lower frequency of ineffective esophageal motility (IEM) compared to CCv3.0.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Mark R. Fox, Rami Sweis, Rena Yadlapati, John Pandolfino, Albis Hani, Claudia Defilippi, Tack Jan, Nathalie Rommel
Summary: The Chicago Classification v4.0 introduces a more rigorous and expansive protocol for identifying esophageal motility disorders through high-resolution manometry testing. Provocative tests aim to increase diagnostic sensitivity and specificity, reducing inconclusive diagnoses and directing effective therapy for patients. The establishment of a standard manometry protocol worldwide also aims to improve procedural consistency, diagnostic reliability, and promote collaborative research.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Abraham Khan, Rena Yadlapati, Sutep Gonlachanvit, David A. Katzka, Moo In Park, Michael Vaezi, Marcelo Vela, John Pandolfino
Summary: The latest update in the diagnostic criteria for achalasia by Chicago Classification version 4.0 introduced subtypes and definitive/inconclusive diagnostic statements. In cases of inconclusive diagnosis, further testing such as functional lumen imaging probe (FLIP) is recommended for clarification.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Editorial Material
Medicine, Research & Experimental
Fernando A. M. Herbella, Leonardo M. Del Grande, Francisco Schlottmann, Marco G. Patti
Summary: The Chicago Classification 4.0 introduces new concepts for the diagnosis of achalasia, potentially reducing unnecessary treatment. Conditions such as esophagogastric junction outflow obstruction, distal esophageal spasm, and hypercontractile esophagus are now considered clinically significant only in certain conditions, leading to a potential decrease in treatment, especially peroral endoscopic myotomy, solely based on manometric diagnosis.
ADVANCES IN THERAPY
(2021)
Article
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Matteo Ghisa, Giulio Del Corso, Federica Baiano Svizzero, Lucia Mariani, Salvatore Tolone, Marzio Frazzoni, Andrea Buda, Massimo Bellini, Vincenzo Savarino, Roberto Penagini, C. Prakash Gyawali, Edoardo V. Savarino, Nicola de Bortoli
Summary: The CCv4.0 criteria significantly decreased the prevalence of EGJOO by 80%, refining the diagnosis and identifying clinically relevant outflow obstruction. Elevated RDC-IRP can predict conclusive EGJOO diagnosis per CCv4.0.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Otorhinolaryngology
Daniel L. Cohen, Basem Hijazi, Ali Omari, Anton Bermont, Haim Shirin, Helal Said Ahmad, Narjes Azzam, Fahmi Shibli, Ram Dickman, Amir Mari
Summary: This study compared the demographic, clinical, endoscopic, and manometric findings of achalasia patients between Israeli Arabs and Israeli Jews. It found that Israeli Arab achalasia patients had different clinical symptoms and higher integrated relaxation pressure compared to Israeli Jewish patients.
Article
Multidisciplinary Sciences
Sudarshan R. Jadcherla, Kathryn A. Hasenstab, Erika K. Osborn, Deborah S. Levy, Haluk Ipek, Roseanna Helmick, Zakia Sultana, Nicole Logue, Vedat O. Yildiz, Hailey Blosser, Summit H. Shah, Lai Wei
Summary: This study demonstrates that an integrated approach with parent-preferred therapy based on mechanistic understanding of VFSS and HRM metrics improves oral feeding outcomes, despite evidence of penetration or aspiration. The application of new knowledge of the physiology of swallowing and airway protection may contribute to these findings.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Corinne Delbaen, Paraskevas Gkolfakis, Jacques Deviere, Daniel Blero, Hubert Louis
Summary: This study retrospectively analyzed the failure rate of esophagogastric junction (EGJ) insertion during high-resolution manometry (HRM) and reported the use of guidewire-assisted procedures. The results showed that insertion of a water-perfused HRM probe using an endoscopically-placed nasogastric guidewire allowed successful assessment of EGJ and esophageal peristalsis in cases where EGJ traversal was not possible.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Surgery
Dolores T. T. Mueller, Brett Parker, Reid Fletcher, Ahmed Sharata, Daniel Davila Bradley, Steven R. R. DeMeester, Kevin M. M. Reavis, Lee L. L. Swanstrom, Christy M. M. Dunst
Summary: The aim of this study was to provide a complete set of HRM data for patients with a normally functioning fundoplication. The results showed that the addition of a fundoplication significantly increased the values of the lower esophageal sphincter. The previously accepted upper limit defining esophageal outflow obstruction may not be clinically applicable after fundoplication.
Article
Medicine, General & Internal
Amir Mari, Rami Sweis
Summary: Dysphagia can range from benign inconvenience to serious morbidity, requiring a detailed clinical assessment to identify underlying diseases. Treatment should be tailored according to the dysmotility phenotype and patient characteristics.
Article
Gastroenterology & Hepatology
Sawangpong Jandee, Kasemsak Jandee
Summary: This study evaluated the diagnostic yield of high-resolution manometry in Thai patients, finding the highest yield in dysphagia patients. However, the test was not as beneficial in detecting clinically relevant esophageal motor disorders in patients presenting with non-dysphagia symptoms.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Jennifer Wellington, Joseph Kim, Donald O. Castell, Guofeng Xie
Summary: Dysphagia lusoria is a rare condition caused by impingement of the esophagus by an aberrant right subclavian artery, leading to progressive difficulty in swallowing. Diagnosis is typically made through various imaging studies and high-resolution impedance manometry, which can help strengthen the diagnosis of true dysphagia lusoria.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Matteo Ghisa, Giorgio Laserra, Elisa Marabotto, Sebastiano Ziola, Salvatore Tolone, Nicola de Bortoli, Marzio Frazzoni, Aurelio Mauro, Roberto Penagini, Vincenzo Savarino, Brigida Barberio, Edoardo Giovanni Giannini, Patrizia Zentilin, C. Prakash Gyawali, Edoardo Savarino
Summary: Achalasia and obstructive motor disorders were found in almost 15% of patients with EoE, suggesting that esophageal eosinophilia might be causing these disorders. Patients who do not respond to standard treatments may require targeted muscle disruption.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Mariam S. Zaghloul, Yasmine A. Elshaer, Mohamed E. Ramadan, Hassan E. ElBatae
Summary: Esophageal motility disorders (EMDs) are often underestimated in Egypt as the main cause of nonobstructive dysphagia (NOD). This HRM-based study used Chicago Classification version 3.0 (CC v3.0) to classify EMD among Egyptian patients with NOD. The study found that achalasia was the most common EMD in Egyptian patients with NOD.
Article
Biochemical Research Methods
Huayu Zhang, Amy Ferguson, Grant Robertson, Muchen Jiang, Teng Zhang, Cathie Sudlow, Keith Smith, Kristiina Rannikmae, Honghan Wu
Summary: Different algorithms for prioritizing disease-associated genes were benchmarked for application in cerebral small vessel disease, with random walk with restart on the heterogeneous network (RWRH) showing the best performance. Although RWRH had bias caused by degree centrality, it had overall better performance for cSVD. Current pure network-based gene prioritization algorithms may not discover novel disease-associated genes not linked to known ones.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Gastroenterology & Hepatology
Michal M. Szczesniak, Taher Omari, Thomas Y. Lam, Marc Wong, Vincent C. T. Mok, Justin C. Y. Wu, Philip I. W. Chiu, Margaret T. Y. Yuen, Raymond K. Tsang, Charles Cock, Joseph J. Sung, Peter Wu
Summary: Oropharyngeal dysphagia is common in Parkinson's disease (PD) and its neurophysiology is complex. This study aimed to investigate the changes in oropharyngeal pressure dynamics in PD and their correlation with clinical characteristics. The results showed that PD patients had impaired upper esophageal sphincter relaxation, increased flow resistance, and higher pharyngeal contractility compared to healthy controls. PD severity and dysphagia severity were associated with certain parameters of oropharyngeal function. These findings suggest that UES dysfunction and increased flow resistance may contribute to dysphagia in PD.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Clinical Neurology
Jason Pui Yin Cheung, Xihe Kuang, Marcus Kin Long Lai, Kenneth Man-Chee Cheung, Jaro Karppinen, Dino Samartzis, Honghan Wu, Fengdong Zhao, Zhaomin Zheng, Teng Zhang
Summary: The study aimed to establish a deep learning-based pipeline for predicting the progression of lumbar disc degeneration (LDD), which achieved high prediction accuracy without human interference.
EUROPEAN SPINE JOURNAL
(2022)
Article
Computer Science, Interdisciplinary Applications
Yang Li, Yue Zhang, Weigang Cui, Baiying Lei, Xihe Kuang, Teng Zhang
Summary: Retinal vessel segmentation is crucial for diagnosing fundus diseases, and this paper proposes a novel method called DE-DCGCN-EE. It uses a dual encoder to preserve edge information during down-sampling, a dynamic-channel graph convolutional network to address the issue of insufficient channel information utilization, and an edge enhancement block to improve the accuracy of fine blood vessel segmentation. Experimental results show that DE-DCGCN-EE outperforms other state-of-the-art methods on five retinal image datasets, indicating its potential clinical application.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Gastroenterology & Hepatology
Taher Omari, Nathalie Rommel, Tack Jan, Michal Szczesniak, Peter Wu, Mistyka Schar, Sebastian Doeltgen, Charles Cock
Summary: Translating:
In oropharyngeal dysphagia, impaired pharyngoesophageal junction (PEJ) opening is reflected by an elevated hypopharyngeal intrabolus pressure (IBP), quantifiable using pharyngeal high-resolution manometry with impedance (P-HRM-I). Transient intrabolus pressurization (TP) phenomena are not sustained and last for only a brief period. We hypothesized that TP patterns reflect impaired coordination between timing of hypopharyngeal bolus arrival and PEJ relaxation.
Chinese Summary:
Transient intrabolus pressurization (TP) in oropharyngeal dysphagia reflects mistimed coordination between bolus arrival and PEJ relaxation, with higher IBP and shorter PEJ relaxation time during TP swallows. In Patients, RT-DCL time difference correlated with IBP, suggesting pathological TP swallows impede bolus flow due to mistimed coordination.
English Summary:
In oropharyngeal dysphagia, transient intrabolus pressurization (TP) patterns may indicate impaired coordination between bolus arrival and PEJ relaxation, leading to an increased IBP and shorter PEJ relaxation time during TP swallows. The mistimed coordination in TP swallows may impede bolus flow and result in a brief period of pharyngeal chamber pressurization by muscular forces, with IBP correlating with RT-DCL time difference in Patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Clinical Neurology
Hao Wu, Jason Pui Yin Cheung, Teng Zhang, Zhi Shan, Xuyang Zhang, Junhui Liu, Shunwu Fan, Fengdong Zhao
Summary: This retrospective study aimed to investigate the risk factors for intraoperative endplate violations and delayed cage subsidence in oblique lateral interbody fusion (OLIF) surgery, as well as the association between low Hounsfield unit (HU) values and these complications. The results showed that intraoperative endplate violations and delayed cage subsidence are not uncommon in OLIF surgery, and HU values can serve as good predictors for these complications.
GLOBAL SPINE JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Sulaimon Idowu, Paul P. Bertrand, Anna K. Walduck
Summary: Traditional models for studying Helicobacter pylori infection have limitations in understanding cancer initiation and translating results due to genetic differences. The development of gastric organoids provides advantages in mimicking human stomach and long-term culture. This review discusses the advantages and limitations of existing models and the application of gastric organoids in studying H. pylori pathogenesis.
Article
Biochemistry & Molecular Biology
Sulaimon Idowu, Paul P. Bertrand, Anna K. Walduck
Summary: Gastric cancer is a significant global disease burden and its etiology is not well understood. The development of organoid cultures has provided insights into gastric homeostasis. By utilizing this model, we can investigate the impact of host genetics and bacterial factors on gastric stem cell proliferation and DNA damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Taher Omari, Charles Cock, Peter Wu, Michal Marcin Szczesniak, Mistyka Schar, Jan Tack, Nathalie Rommel
Summary: This study aimed to establish a methodology for diagnosing oropharyngeal disorders using P-HRM-I. The results showed that UES relaxation pressure was the best indicator for differentiating patients from controls and diagnosing UES disorders. A diagnostic scheme was also devised to identify patients with UES disorder or propulsive disorder. Additionally, the study found that patients with pharyngeal pressurizations and evidence of reduced UES relaxation and/or distensibility had higher aspiration scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Orthopedics
Jason Pui Yin Cheung, Xihe Kuang, Teng Zhang, Kun Wang, Cao Yang
Summary: The study aims to establish and validate a deep learning pipeline called EDPP-Flow for the 5-year progression prediction of Schmorl's node, HIZ, and Modic changes based on clinical MRIs. By adopting MRI-SegFlow and convolutional neural network, our pipeline achieved high prediction accuracy on an unbalanced dataset.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Medicine, General & Internal
Hongfei Wang, Teng Zhang, Changmeng Zhang, Liangyu Shi, Samuel Yan-Lik Ng, Ho-Cheong Yan, Karen Ching-Man Yeung, Janus Siu-Him Wong, Kenneth Man-Chee Cheung, Graham Ka-Hon Shea
Summary: This study developed a machine learning-based prediction model to accurately predict the risk of progression in adolescent idiopathic scoliosis (AIS) curves. By integrating clinical data, X-rays, and hand X-rays, the model can predict the risk of curve progression at the first clinic visit.
Article
Clinical Neurology
Kenneth Chu, Xihe Kuang, Prudence W. H. Cheung, Sofia Li, Teng Zhang, Jason Pui Yin Cheung
Summary: This study developed a neural network model that integrated clinical and radiological data to predict curve progression in patients with adolescent idiopathic scoliosis. The results showed that this multidimensional-input model had good performance in predicting curve progression and could serve as a screening tool.
GLOBAL SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Nan Meng, Kwan-Yee K. Wong, Moxin Zhao, Jason P. Y. Cheung, Teng Zhang
Summary: This study developed a radiation-free portable system and device using light-based depth sensing and deep learning technologies to analyze Adolescent Idiopathic Scoliosis (AIS). The device can provide instantaneous and accurate spine alignment analysis without radiation exposure, with the potential for integration into routine screening.
Article
Medicine, General & Internal
Nan Meng, Jason P. Y. Cheung, Kwan-Yee K. Wong, Socrates Dokos, Sofia Li, Richard W. Choy, Samuel To, Ricardo J. Li, Teng Zhang
Summary: This study developed a hybrid model called SpineHRNet+ that integrates artificial intelligence and rule-based methods to improve the reliability and interpretability of spine alignment auto-analysis. The results showed that the model achieved accurate landmark detection and strong correlation with ground truth alignment. It has the potential to assist clinical work and facilitate large-scale clinical studies.
Proceedings Paper
Computer Science, Artificial Intelligence
Xihe Kuang, Jason Pui Yin Cheung, Xiaowei Ding, Teng Zhang
Summary: This paper introduces a hybrid-supervised model generation strategy called SpineGEM, which can efficiently produce a high-performing deep learning model for pathological classification of lumbar degenerative diseases. By utilizing a unique self-supervised learning process and integrating anatomical prior information, the model can achieve accurate pathology classifications with fine-tuning on a small dataset.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2021, PT II
(2021)
