Article
Medicine, Research & Experimental
Seh Ling Kwong, Ester G. Hernandez, Katharina Winiker, Kristin Gozdzikowska, Phoebe Macrae, Maggie-Lee Huckabee
Summary: This study examined the effect of topical nasal anesthetic (TNA) on swallowing and tolerability during high-resolution impedance manometry (HRIM) with a 4.2-mm catheter. The results showed that TNA did not improve comfort or significantly affect swallowing behavior during the procedure.
Article
Gastroenterology & Hepatology
Lara Ferris, Sebastian Doeltgen, Charles Cock, Nathalie Rommel, Mistyka Schar, Silvia Carrion, Ingrid Scholten, Taher Omari
Summary: The study evaluated the neuromodulation of healthy oropharyngeal swallowing using high-resolution pharyngeal manometry with impedance, finding significant modulation effects of bolus volume and viscosity on hypopharyngeal intrabolus pressure and upper esophageal sphincter metrics. Increased bolus volumes led to elevated pharyngeal contractility and postswallow pressures, while bolus viscosity only affected UES preopening pressure. These findings contribute to the diagnostic framework for oropharyngeal dysphagia.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Surgery
Chih-Jun Lai, Ya-Jung Cheng, Dar-Ming Lai, Chun-Yu Wu, Wen-Ting Chang, Fon-Yih Tsuang
Summary: Objective assessment of perioperative swallowing changes is crucial for patients undergoing ACSS. HRIM was used to evaluate swallowing objectively, and the results showed a significant increase in SRI on postoperative day 1, followed by recovery on day 7. This study demonstrated that HRIM is superior to DSQ in detecting mechanisms and monitoring the recovery from swallowing dysfunction.
FRONTIERS IN SURGERY
(2022)
Article
Otorhinolaryngology
Jodi Hernandez, Glen Leverson, Susan Thibeault
Summary: The study found that patients prefer atomized lidocaine for increased comfort during pharyngeal high-resolution manometry procedures. While no significant differences were detected in pharyngeal pressure measurements between the two groups, the use of atomized lidocaine did not affect measurement outcomes.
Article
Audiology & Speech-Language Pathology
Niall Heslin, Julie Regan
Summary: This study found that effortful swallowing significantly affects the pharyngeal swallowing biomechanics in adults with dysphagia, including an increase in pharyngeal contractile and opening duration. This suggests that effortful swallowing can improve swallowing difficulties and warrants further investigation in larger clinical populations.
INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Taher Omari, Charles Cock, Shu-Wei Liang, Chandra Prakash Gyawali, Chien-Lin Chen
Summary: This study aimed to evaluate the feasibility and usefulness of CSI with SLR in complementing the diagnosis of GERD. Results showed that impedance-based metrics were lower in GERD patients compared to non-GERD patients. Particularly, the SLR maneuver increased diagnostic accuracy of CSI for GERD identification, especially in IEM patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, General & Internal
Kenjiro Kunieda, Junya Sugiyama, Akiko Nomoto, Tomohisa Ohno, Takashi Shigematsu, Ichiro Fujishima
Summary: This case study explores the compensatory swallowing methods observed in individuals recovering from dysphagia due to lateral medullary syndrome (LMS), specifically vacuum swallowing and prolonged swallowing. Further research is needed to understand the relationship between these methods and the pathophysiology, prognosis, and treatment of dysphagia in LMS patients.
Article
Surgery
Theresa N. Wang, Jennifer Underhill, Robert Tamer, Kyle A. Perry, Kelly R. Haisley
Summary: This study aimed to investigate the correlation between IP and HRM in the pre-operative evaluation of GERD. The results showed that IP had a sensitivity of 65.8% and a specificity of 50% in detecting normal motility.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, Research & Experimental
Jianrong Zhang, Yu'e Wu, Yanfang Huang, Shuqing Zhang, Liuqin Xu, Xiaoyun Huang, Xingshui Wang, Qingping Huang
Summary: The Mendelsohn maneuver and swallowing training can improve swallowing function in patients with senile vascular dementia complicated with dysphagia and help to ameliorate the inflammatory response.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Miho Ohashi, Yoichiro Aoyagi, Satoshi Ito, Hitoshi Kagaya, Masatoshi Hirata, Seiichi Nakata
Summary: This study assessed the accuracy and efficiency of high-resolution manometry (HRM) topography, electromyography (EMG), sound, and bioimpedance waveforms for identifying swallowing events. The results showed that HRM topography had the highest classification accuracy, followed by sound and bioimpedance waveforms, while EMG waveform had the lowest classification accuracy. Therefore, HRM, sound, bioimpedance, and EMG are potential methods for counting swallowing events in screening for dysphagia, but further study is needed.
MEDICAL ENGINEERING & PHYSICS
(2023)
Article
Pediatrics
Anna Maria Caruso, Denisia Bommarito, Vincenza Girgenti, Glenda Amato, Adele Figuccia, Alessandra Casuccio, Annalisa Ferlisi, Rosaria Genuardi, Sabrina La Fata, Rosalia Mattei, Mario Pietro Marcello Milazzo, Maria Rita Di Pace
Summary: This study analyzed swallowing functions in neurologically impaired (NI) children using esophageal high-resolution manometry (HRM) and established swallow parameters identifying inhalation risk. The results showed alterations in swallowing functions in NI children, which could predispose them to increased inhalation risk.
Article
Gastroenterology & Hepatology
Arvind Rengarajan, Benjamin D. Rogers, Zhiqin Wong, Salvatore Tolone, Daniel Sifrim, Jordi Serra, Edoardo Savarino, Sabine Roman, Jose M. Remes-Troche, Rosa Ramos, Julio Perez de la Serna, Ans Pauwels, Ana Maria Leguizamo, Yeong Yeh Lee, Osamu Kawamura, Jamal Hayat, Albis Hani, Sutep Gonlachanvit, Daniel Cisternas, Dustin Carlson, Serhat Bor, Shobna Bhatia, Luiz Abrahao, John Pandolfino, C. Prakash Gyawali
Summary: The study aimed to investigate the prevalence of abnormal esophageal motor patterns in healthy individuals. Results showed that motor abnormalities are infrequent in healthy individuals and consist mainly of ineffective esophageal motility (IEM), with lower proportions when using stringent criteria in the supine position. Thresholds for HRM metrics varied across HRM systems and study positions.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Asad Jehangir, Zubair Malik, Henry P. Parkman
Summary: This study aimed to examine the correlation between reflux observed on esophagogastric junction (EGJ) during high-resolution esophageal manometry with impedance (HREMI) and reflux on conventional esophageal reflux monitoring studies. The results showed that about 20.5% of patients undergoing HREMI had pathologic reflux at EGJ. Patients with reflux on HREMI more frequently had gastroesophageal reflux disease (GERD) on ambulatory pH monitoring. However, reflux on HREMI had low sensitivity for GERD.
BMC GASTROENTEROLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Kristin J. Teplansky, Corinne A. Jones
Summary: This study found that pharyngeal swallowing pressure variability increases during volitional swallowing tasks in healthy individuals. The type of swallowing task and the pharyngeal region both have significant effects on pressure variability, but there is no significant interaction between the two.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sudarshan R. Jadcherla, Kathryn A. Hasenstab, Erika K. Osborn, Deborah S. Levy, Haluk Ipek, Roseanna Helmick, Zakia Sultana, Nicole Logue, Vedat O. Yildiz, Hailey Blosser, Summit H. Shah, Lai Wei
Summary: This study demonstrates that an integrated approach with parent-preferred therapy based on mechanistic understanding of VFSS and HRM metrics improves oral feeding outcomes, despite evidence of penetration or aspiration. The application of new knowledge of the physiology of swallowing and airway protection may contribute to these findings.
SCIENTIFIC REPORTS
(2021)
Article
Otorhinolaryngology
Howell Henrian G. Bayona, Nicole Pizzorni, Jan Tack, Ann Goeleven, Taher Omari, Nathalie Rommel
Summary: This study demonstrates the diagnostic value of certain proposed and adjunct HRPM metrics for identifying signs of unsafe and inefficient bolus transport in patients with oropharyngeal dysphagia.
Article
Clinical Neurology
Mistyka S. Schar, Taher Omari, Charmaine M. Woods, Charles Cock, Sebastian H. Doeltgen, Ching Li Chai-Coetzer, Danny J. Eckert, Theodore Athanasiadis, Eng H. Ooi
Summary: This study assessed the effect of contemporary multi-level upper airway surgery on swallowing function in obstructive sleep apnea patients. The results showed that modified uvulopalatopharyngoplasty may have less implications on the swallow mechanism than previously thought, while coblation channeling of the tongue may affect bolus propulsion.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Jessica A. Eldredge, Taher Omari, David J. Moore
Summary: Lower baseline impedance was found across the esophageal length in children with eosinophilic esophagitis (EoE), indicating its potential as an important adjunct for monitoring treatment response. However, the relationship between baseline impedance and eosinophil number at corresponding esophageal segments was not established.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Medicine, Research & Experimental
Joeke L. Nollet, Per Cajander, Lara F. Ferris, Jordache Ramjith, Taher Omari, Johanna Savilampi
Summary: The study aimed to investigate the effects of bolus volume and viscosity on pharyngeal swallow using circumferential pressure sensor technology and found that larger volumes increased intrabolus pressure and all upper esophageal sphincter metrics, while thicker viscosity decreased UES relaxation time and flow timing metrics. The use of this technology provides consistent results with previous reports, offering insights into aberrant pharyngo-esophageal motor responses over time.
Article
Gastroenterology & Hepatology
Taher Omari, Nathalie Rommel, Tack Jan, Michal Szczesniak, Peter Wu, Mistyka Schar, Sebastian Doeltgen, Charles Cock
Summary: Translating:
In oropharyngeal dysphagia, impaired pharyngoesophageal junction (PEJ) opening is reflected by an elevated hypopharyngeal intrabolus pressure (IBP), quantifiable using pharyngeal high-resolution manometry with impedance (P-HRM-I). Transient intrabolus pressurization (TP) phenomena are not sustained and last for only a brief period. We hypothesized that TP patterns reflect impaired coordination between timing of hypopharyngeal bolus arrival and PEJ relaxation.
Chinese Summary:
Transient intrabolus pressurization (TP) in oropharyngeal dysphagia reflects mistimed coordination between bolus arrival and PEJ relaxation, with higher IBP and shorter PEJ relaxation time during TP swallows. In Patients, RT-DCL time difference correlated with IBP, suggesting pathological TP swallows impede bolus flow due to mistimed coordination.
English Summary:
In oropharyngeal dysphagia, transient intrabolus pressurization (TP) patterns may indicate impaired coordination between bolus arrival and PEJ relaxation, leading to an increased IBP and shorter PEJ relaxation time during TP swallows. The mistimed coordination in TP swallows may impede bolus flow and result in a brief period of pharyngeal chamber pressurization by muscular forces, with IBP correlating with RT-DCL time difference in Patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, Research & Experimental
Jui-Sheng Hung, Shu-Wei Liang, Taher Omari, Ming-Wun Wong, Wei-Yi Lei, Chih-Hsun Yi, Tso-Tsai Liu, Lin Lin, Chien-Lin Chen
Summary: The effects of baclofen on volitional swallowing measures are limited, but it reduces the likelihood of initiation of piecemeal deglutition to large volume challenges.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Taher Omari, Charles Cock, Peter Wu, Michal Marcin Szczesniak, Mistyka Schar, Jan Tack, Nathalie Rommel
Summary: This study aimed to establish a methodology for diagnosing oropharyngeal disorders using P-HRM-I. The results showed that UES relaxation pressure was the best indicator for differentiating patients from controls and diagnosing UES disorders. A diagnostic scheme was also devised to identify patients with UES disorder or propulsive disorder. Additionally, the study found that patients with pharyngeal pressurizations and evidence of reduced UES relaxation and/or distensibility had higher aspiration scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Per Cajander, Taher Omari, Anders Magnuson, Harry Scheinin, Mika Scheinin, Johanna Savilampi
Summary: Dexmedetomidine affects pharyngeal swallowing and esophageal motility, which should be considered in clinical patient management and when choosing sedative agents for procedural sedation or manometric examination.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Gastroenterology & Hepatology
Per Cajander, Taher Omari, Harry Scheinin, Mika Scheinin, Johanna Savilampi
Summary: It is important to consider the impact of anesthetic agents on esophageal function testing. Dexmedetomidine has been found to affect primary peristalsis in esophageal manometry, and in the case reports by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be due to a specific pharmacodynamic effect, with a transient direct alpha 2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration before sympathetic inhibition begins.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Oncology
Norma B. Bulamu, Gang Chen, Ellen Mcgrane, Charles Cock, Graeme P. Young, Erin L. Symonds
Summary: This study compares the sensitivity and discriminant validity of generic and cancer-specific measures for assessing health-related quality of life (HRQoL) for individuals undergoing diagnostic or surveillance colonoscopy for colorectal cancer. The results show that patients undergoing colonoscopy for symptoms have lower HRQoL compared to surveillance or positive FOBT. The cancer-specific QLU-C10D was found to be more sensitive and capable of distinguishing between patients undergoing colonoscopy for different indications.
CANCER CAUSES & CONTROL
(2023)
Article
Gastroenterology & Hepatology
Meghan I. Barnett, Molla M. Wassie, Charles Cock, Peter A. Bampton, Erin L. Symonds
Summary: Family history of colorectal cancer does not significantly increase the risk of advanced neoplasia following a normal index colonoscopy. Age is the main risk factor for advanced neoplasia in this population. Delaying onset of colonoscopy or lengthening surveillance intervals may be more efficient.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Critical Care Medicine
Sanith S. Cheriyan, Mistyka S. Schar, Charmaine M. Woods, Shailesh Bihari, Charles Cock, Theodore Athanasiadis, Taher I. Omari, Eng H. Ooi
Summary: This study aimed to investigate the mechanistic effects of a tracheostomy on swallowing using pharyngeal high-resolution manometry with impedance (P-HRM-I). The results showed that in tracheostomised patients, there were significant increases in hypopharyngeal intrabolus pressure and upper oesophageal sphincter (UOS) integrated relaxation pressure, as well as reductions in UOS opening extent and relaxation time. Total pharyngeal contractility was also significantly elevated. These findings suggest that tracheostomy may result in UOS dysfunction, but does not contribute to pharyngeal weakness.
CRITICAL CARE AND RESUSCITATION
(2023)
Article
Surgery
Joseph J. Fantasia, Charles Cock, David I. Watson, Tim Bright, Sarah K. Thompson
Summary: Gastroesophageal reflux disease affects a significant portion of the population worldwide. Minimally invasive laparoscopic fundoplication is an effective treatment for selected patients. However, a small percentage of patients may require revisional surgery. Endoscopy plays an important role in evaluating the outcomes of fundoplication surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)