Review
Environmental Sciences
Seyed Rohallah Mousavibaygei, Amir Bisadi, Fariba ZareSakhvidi
Summary: This study systematically reviewed the evidence on the association between exposure to air pollution and osteoporosis-related outcomes. The findings suggest that PM2.5, PM10, and nitrogen dioxide may be associated with decreased bone density, osteoporotic fractures, and osteoporosis. However, due to limitations in the number of studies, heterogeneity, and publication bias, caution should be exercised in interpreting the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell & Tissue Engineering
H. Xie, N. Wang, H. He, Z. Yang, J. Wu, T. Yang, Y. Wang
Summary: In this meta-analysis, the association between selenium status and bone health indicators was investigated. The results demonstrate a positive correlation between selenium intake and bone mineral density, as well as an inverse relationship with osteoporosis and hip fracture risk.
BONE & JOINT RESEARCH
(2023)
Review
Food Science & Technology
Weili Feng, Xiaoping Wang, Daoqiang Huang, Anqi Lu
Summary: This study used an umbrella review and meta-analysis to summarize the association between dietary factors and the incidence of osteoporosis in adults. The findings suggest that dietary factors have an impact on osteoporosis, and consuming appropriate amounts of dairy products, vegetables, fruits, and micronutrients, while reducing alcohol and coffee intake, can help reduce the risk of osteoporosis.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Chia-Hsien Chen, Wei-Cheng Lo, Ping-Jen Hu, Hsiu-Chen Chan, Wan-Chen Shen, Mai-Szu Wu, Mei-Yi Wu
Summary: From network meta-analysis, it was found that teriparatide and denosumab appear to be the most effective treatments for preventing bone loss and reducing the risk of fracture in patients with CKD or a history of kidney transplantation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
JJ. Liu, SB. Fu, J. Jiang, XL. Tang
Summary: Exposure to air pollution, specifically PM2.5 and NO2, was associated with an increased risk of osteoporosis, while PM10, NO, and O-3 did not show a significant excess risk. Despite the limited number of epidemiological studies, this research suggests a positive correlation between increased exposure to air pollutants and a higher osteoporosis risk. Further large cohort studies are needed to investigate the impact of different constituents and duration of air pollutants exposure.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Panagiotis Anagnostis, Kalliopi Lampropoulou-Adamidou, Julia K. Bosdou, Georgios Trovas, Petros Galanis, Efstathios Chronopoulos, Dimitrios G. Goulis, Symeon Tournis
Summary: The optimal management of pregnancy and lactation-associated osteoporosis (PLO) has not been determined. Existing studies have found that calcium/vitamin D, bisphosphonates, and teriparatide can improve bone mineral density, with teriparatide showing better efficacy. However, due to heterogeneity and lack of robust comparative data, safe conclusions cannot be drawn regarding the optimal therapeutic intervention in women with PLO.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Q. Zhu, J. Xu, M. Zhou, X. Lian, J. Xu, J. Shi
Summary: This meta-analysis found a significant decrease in BMD Z-scores in children with type 1 diabetes mellitus, independent of age, level of glucose control, and prepubertal stage. The results were consistent in studies from Asia and South America, but inconsistent in North America and Europe. The findings suggest that type 1 diabetes mellitus may play a role in decreasing BMD Z-scores in children and adolescents.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
Review
Endocrinology & Metabolism
Ying-Hao Su, Kuo-Liong Chien, Shu-Hua Yang, Wei-Tso Chia, Jen-Hau Chen, Yen-Ching Chen
Summary: This systematic review and meta-analysis found that nonalcoholic fatty liver disease (NAFLD) is associated with decreased bone mineral density (BMD) and increased risks of osteoporosis and osteoporotic fractures in adults. Male sex and the BMD of the femoral neck and total hip are potential risk factors for decreased BMD in adults with NAFLD. Ethnic disparities exist between Asian and non-Asian populations regarding BMD and osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Orthopedics
Filippo Migliorini, Nicola Maffulli, Giorgia Colarossi, Joerg Eschweiler, Markus Tingart, Marcel Betsch
Summary: This study found that Denosumab has a higher impact on spine bone mineral density in selected postmenopausal women, and has the highest influence on hip and femur bone mineral density.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Endocrinology & Metabolism
Chin-Hao Hsu, Sheng-Feng Sung, Hsin-Yi Yang, Wan-Ting Huang, Cheng-Yang Hsieh
Summary: Despite being at higher risk, stroke survivors are less likely to receive bone mineral density testing and osteoporosis treatment compared to non-stroke patients. Factors such as female sex, osteoporosis, prior BMD testing, and low-trauma fractures after stroke increase the likelihood of receiving these measures, while greater stroke severity reduces the likelihood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Letter
Endocrinology & Metabolism
Michael S. Hughes, Ryan Bailey, Peter Calhoun, Viral N. Shah, Sarah K. Lyons, Daniel J. DeSalvo
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Gregory L. Kinney, Anagha Champakanath, Andrew Monte, Viral N. Shah
Summary: The study aimed to differentiate between diabetic ketoacidosis (DKA) and hyperglycemic ketosis due to cannabis hyperemesis syndrome (HK-CHS) in adults with type 1 diabetes. It was found that cannabis users had higher levels of pH and bicarbonate compared to non-users. A positive urine test result for cannabis could be used to predict the occurrence of HK-CHS.
Article
Endocrinology & Metabolism
Anagha Champakanath, Halis Kaan Akturk, G. Todd Alonso, Janet K. Snell-Bergeon, Viral N. Shah
Summary: Initiating continuous glucose monitoring within the first year of type 1 diabetes diagnosis leads to long-term improvement in A1c levels.
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Pau Herrero, Nick Oliver, Haley Wise, Emma Eikermann, Janet Snell-Bergeon, Viral N. Shah
Summary: The study suggests that random CGM data loss up to 50% does not significantly affect the optimal sampling duration for CGM metrics, but losing data with longer gaps increases the MdAPE crossing threshold, requiring a longer optimal sampling duration.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Review
Endocrinology & Metabolism
Mona Elbalshy, Jillian Haszard, Hazel Smith, Sarahmarie Kuroko, Barbara Galland, Nick Oliver, Viral Shah, Martin I. de Bock, Benjamin J. Wheeler
Summary: This systematic review and meta-analysis found that the use of continuous glucose monitoring (CGM) systems had a significant positive impact on glycemic outcomes including HbA1c, time-in-range (TIR), and time-below-range (TBR) in individuals with type 1 diabetes. The results demonstrated that adjunctive CGM and non-adjunctive CGM were particularly effective in improving glycemic control.
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Viral N. Shah
Summary: This study investigated the long-term outcomes of the Tandem Control IQ automated insulin delivery system in adults with poorly controlled type 1 diabetes. The results showed that regardless of the users' engagement, the system effectively lowered A1c and improved time in target range without increasing the risk of hypoglycemia.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Viral N. Shah, Halis K. Akturk, Tim Vigers, Laura Pyle, Nick Oliver, David C. Klonoff
Summary: Daytime versus nighttime glycemic control has similar influence on A1C in adults with T1D.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Letter
Endocrinology & Metabolism
Aria L. Saunders, Cathy Bodine, Janet Snell-Bergeon, Gregory P. Forlenza, Viral N. Shah
Article
Endocrinology & Metabolism
Viral N. Shah, Casey Sakamoto, Laura Pyle
Summary: This study aimed to evaluate the optimal duration of continuous glucose monitoring (CGM) sampling for estimating glycemia risk index (GRI). CGM data of 225 nonpregnant adults with type 1 diabetes were collected and it was found that longer sampling periods had higher correlation with the 90-day GRI, with 14 days being the optimal duration for estimation.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Viral N. Shah, Tim Vigers, Laura Pyle, Peter Calhoun, Richard M. Bergenstal
Summary: The use of continuous glucose monitor (CGM) is increasing in healthy individuals without diabetes. However, there is a discrepancy between glucose management indicator (GMI) and glycated hemoglobin (HbA1c) in this population.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Kagan E. Karakus, Viral N. Shah, David Klonoff, Halis K. Akturk
Summary: This study aimed to evaluate the glycaemia risk index (GRI) and its association with other continuous glucose monitoring (CGM) metrics after initiation of an automated insulin delivery (AID) system. The study found that GRI was highly correlated with various CGM metrics above target range, but not below.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Viral N. Shah, Amer Al-Karadsheh, Cathy Barnes, Jose Mandry, Samer Nakhle, Karin Wernicke-Panten, Daniel Kramer, Wolfgang Schmider, Suzanne Pierre, Lenore Teichert, Baerbel Rotthaeuser, Bhaswati Mukherjee, Timothy S. Bailey
Summary: This study assessed the impact of switching frequency between SAR341402 biosimilar insulin aspart (SAR-Asp) and insulin aspart reference product (NN-Asp) on the pharmacokinetic exposure in adults with type 1 diabetes. The results showed no significant differences in pharmacokinetic exposure between the switching and non-switching groups, supporting the interchangeability of these two insulin aspart products.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Viral N. Shah
Summary: Continuous glucose monitoring (CGM) metrics such as time in range and time below range (TBR) are recommended alongside glycated hemoglobin (A1c) for diabetes care optimization. However, expressing TBR as an integer percentage and rounding-off numerical values may lead to misleading interpretations. This article aims to generate more discussion on reporting TBR in ways that are clinically impactful for diabetes patients, healthcare providers, regulatory agencies, and payers in predicting severe hypoglycemic events.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Viral N. Shah, Shijing Qui, Jason Stoneback, Lubna Qamar, Virginia L. Ferguson, Wendy M. Kohrt, Janet K. Snell-Bergeon, Sudhaker D. Rao
Summary: This study investigated bone structure and turnover in postmenopausal women with type 1 diabetes (T1D). The results showed that T1D may affect bone turnover, mainly bone formation, without significantly affecting bone structure.
Article
Endocrinology & Metabolism
Halis Kaan Akturk, Janet Snell-Bergeon, Gregory L. Kinney, Anagha Champakanath, Andrew Monte, Viral N. Shah
Summary: The study found that cannabis users had significantly higher pH and bicarbonate levels compared to non-users, and the accuracy of predicting HK-CHS with a positive cannabis urine test result was high.