Journal
ORGANOMETALLICS
Volume 36, Issue 13, Pages 2418-2423Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.7b00309
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Funding
- Science and Engineering Research Board, India
- CSIR
- UGC-INDIA
- IIT Bombay
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Selective meta-C-H activation of arenes to date has met with a limited number of functionalizations. Expanding the horizon of meta-C-H functionalization, herein we disclose an unprecedented meta-silylation and -germanylation protocol by employing a simple nitrile-based directing template. Longer linkers between the target site and the directing template were successfully explored for meta-silylation (sp(2)-epsilon and sp(2)-zeta). Additionally, synthetic utility was demonstrated with several postsynthetic elaborations and with a formal synthesis of TAC101, a promising drug for the treatment of lung cancer.
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