Cobalt(III)-Catalyzed Oxadiazole-Directed C-H Activation for the Synthesis of 1-Aminoisoquinolines

Aromatic heterocycles have been identified as effective directing groups (DGs) in C-H functionalization but Can be retainedas undesired bulky substituents in the final products. Herein, we report, a CO(III)-catalyzed 1-aminoisoquinoline synthesis stfategy based on oxadiazole-directed aromatic C-H, coupling with,alkynes aria a subsequent redox-neutal C-N cyclization reaction. This labile N-O bond-based protocol has allowed the toleration of a broad range of fynctional group.