4.8 Article

Palladium-Catalyzed Domino Heck/Aryne Carbopalladation/C-H Functionalization: Synthesis of Heterocycle-Fused 9,10-Dihydrophenanthrenes

Journal

ORGANIC LETTERS
Volume 19, Issue 4, Pages 842-845

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03833

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Funding

  1. Shaanxi University of Science and Technology [BJ15-33]

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A novel palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization reaction using in situ generated arynes has been developed in which three new C-C bonds and a carbon quaternary center are formed. This methodology affords moderate to excellent yields of heterocycle-fused 9,10-dihydrophenanthrenes.

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