Journal
ORGANIC LETTERS
Volume 19, Issue 24, Pages 6700-6703Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03422
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Funding
- CNRS
- Univ. Paris-Sud
- La Ligue Contre le Cancer through an Equipe Labellisee
- ANR [ANR-10-LABX-33]
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A novel, sequential, palladium-catalyzed, cross-coupling reaction using N-tosylhydrazone and bromonitrobenzene derivatives followed by reductive cyclization has been developed. This transformation providing an efficient route to unexpected N-arylindole derivatives involves, in a one-pot reaction, the formation of one Csp(2)-Csp(2) bond and two Csp(2)-N bonds together with the cleavage of one Csp(2)-heteroatom bond. Evaluation of the biological activity led to the identification of compound 5a, which displays potent activity at nanomolar concentrations against human colon carcinoma cell line.
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