Journal
ORGANIC LETTERS
Volume 19, Issue 3, Pages 690-693Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03862
Keywords
-
Categories
Funding
- Wuhan University [203413100003]
- Important Sci-Tech Innovative Project of Hubei Province [2015ACA058]
- National Natural Science Foundation of China [21372179, 21432007, 21473086, 21502145]
- Shenzhen Peacock Program [KQTD20150717103157174]
Ask authors/readers for more resources
A series of tridentate ferrocene-based amino-phosphine acid (f-Ampha) ligands have been successfully developed. The f-Ampha ligands are extremely air stable and exhibited excellent performance in the Ir-catalyzed asymmetric hydrogenation of ketones (full conversions, up to >99% ee, and 500 000 TON). DFT calculations were performed to elucidate the reaction mechanism and the importance of the -COOH group. Control experiments also revealed that the -COOH group played a key role in this reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available