Reversal of Enantioselectivity Approach to BINOLs via Single and Dual 2-Naphthol Activation Modes

A mechanism-driven-enantio divergent approach to chiral 1,1'-bi-2-naphthols via,catalytic asymmetric oxidative coupling of 2-naphthol derivatives is described for the first time. By utilizing 2-naphthol derivatives with low oxidation potential, the substrates,Were activated by either-chiral niononuclear or dinuclear vanadium(V) catalyst to promote distinctively different asymmetric reaction pathways: single versus dual substrate activation mechanisms.