4.8 Article

Design and Applications of N-tert-Butyl Sulfinyl Squaramide Catalysts

Journal

ORGANIC LETTERS
Volume 19, Issue 7, Pages 1926-1929

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00727

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Funding

  1. NNSFC at Nankai University [21390400, 21421062]
  2. National Science Foundation of the USA [CHE-11853]

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A new chiral HBD system, N-tert-butyl sulfinyl squaramide, was designed and synthesized. The core N-tert-butyl sulfinyl squaramide with an 1-aminoindan-2-ol skeleton was found to be an efficient catalyst in the enantioselective Friedel-Crafts alkylation of indoles and acyl phosphonates.

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