Journal
ORGANIC LETTERS
Volume 19, Issue 17, Pages 4600-4603Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02203
Keywords
-
Categories
Funding
- CAS Interdisciplinary Innovation Team
- National Natural Science Foundation of China [21672199]
Ask authors/readers for more resources
A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles and 2-(2-aminoethyl)pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available