4.8 Article

SN1-Type Alkylation of N-Heteroaromatics with Alcohols

Journal

ORGANIC LETTERS
Volume 19, Issue 21, Pages 5724-5727

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02294

Keywords

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Funding

  1. NSFC [21702117, 21776148]
  2. Natural Science Foundation of Shandong Province [JQ201604, ZR2016BM07, ZR2017BB005]
  3. Key Research and Development Program of Shandong Province [2017GSF218073]
  4. Qingdao Special Research Foundation of Science and Technology [16-6-2-29 nsh]

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The organocatalytic-alkylation of 2-methyl-N-heteroaroinatics with alcohols has been achieved via S(N)1-type C(sp(3)) H functionalization, providing a green and efficient synthesis of indole and ferrocene-functionalized N-heteroaromatics in high yields.

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