4.6 Article

Ru(II)-Catalyzed annulation of benzamidines and alkynes by C-H/N-H activation: a facile synthesis of 1-aminoisoquinolines

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 16, Pages 3491-3498

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00389g

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Funding

  1. SERB, New Delhi [GPP-0303 (YSS/2014/001018)]
  2. UGC

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An inexpensive Ru(II) complex catalyzes the oxidative annulation reaction of disubstituted alkynes with benzamidines to provide highly valuable 1-aminoisoquinolines in high yields. The reaction also features excellent regioselectivity with some unsymmetrical alkynes.

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