Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 45, Pages 9552-9565Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02094e
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Funding
- NSFC [21572109]
- Natural Science Foundation of Tianjin City [15JCYBJC53300]
- National Thousand Young Talents Program
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Owing to the unique physical properties of a fluorine atom, incorporating fluoro-modifications into nucleic acids offers striking biophysical and biochemical features, and thus significantly extends the breadth and depth of biological applications of nucleic acids. In this review, fluoro-modified nucleic acids that have been synthesized through either solid phase synthesis or the enzymatic approach are briefly summarised, followed by a section describing their biomedical applications in nucleic acid-based therapeutics, F-18 PET imaging and mechanistic studies of DNA modifying enzymes. In the last part, the utility of F-19 NMR and MRI for probing the structure, dynamics and molecular interactions of fluorinated nucleic acids is reviewed.
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