4.6 Article

A formal intermolecular [4+2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 16, Pages 3472-3478

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00392g

Keywords

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Funding

  1. National Natural Science Foundation of China [81473080, 81573299, 21502230, 31501182]
  2. Jiangsu Province Natural Science Foundation [BK20150688]
  3. 111 Project from the Ministry of Education of China
  4. State Administration of Foreign Expert Affairs of China [111-2-07]
  5. Program for Changjiang Scholars and Innovative Research Team in University [IRT1193]
  6. Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University [SKLNMZZYQ201607]

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A formal [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones was realized to furnish polycyclic indolines in good yields. This protocol proceeded smoothly under basic conditions, with high atom-economy and broad substrate scope.

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