Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 10, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00081b
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Funding
- Belgian Stichting tegen Kanker
- FWO Flanders
- NIH [AI070258]
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alpha-GalCer analogues that combine known Th1 polarizing C6''-modifications with a C-glycosidic linkage were synthesized. We employed a protecting group strategy that allowed the preparation of both saturated and unsaturated derivatives with variable C6''-substituents. Selected analogues demonstrate promising activity in mice. Interestingly, the introduction of a 6''-O-pyridinylcarbamoyl substituent to alpha-C-GalCer restores its antigenicity in human iNKT cells.
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