Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 47, Pages 10116-10121Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01828b
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Funding
- University of Malta
- Strategic Educational Pathways Scholarship (Malta) program by the European Union Social Fund (ESF) under Operational Programme II
- ENDEAVOUR Scholarships Scheme
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A novel fluorescent molecular logic gate with a 'fluorophore-spacer(1)-receptor(1)-spacer(2)-receptor(2)' format is demonstrated in 1 : 1 (v/v) methanol/water. The molecule consists of an anthracene fluorophore, and tertiary alkyl amine and N-(2-methoxyphenyl)aza-15-crown-5 ether receptors. In the presence of threshold concentrations of H+ and Na+, the molecule switches 'on' as an AND logic gate with a fluorescence quantum yield of 0.21 with proton and sodium binding constants of log beta(H+) = 9.0 and log beta(Na+) = 3.2, respectively. At higher proton levels, protonation also occurs at the anilinic nitrogen atom ether with a log beta(H+) = 4.2, which allows for Na+, H+-enabled OR (OR + AND circuit) and H+-driven ternary logic functions. The reported molecule is compared and contrasted to classic anthracene-based Na+ and H+ logic gates. We propose that such logic-based molecules could be useful tools for probing the vicinity of Na+, H+ antiporters in biological systems.
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