4.6 Article

Synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 29, Pages 6080-6083

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01337j

Keywords

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Funding

  1. National Natural Science Foundation of China Grant [21302096, 21502093]
  2. Natural Science Foundation of Jiangsu Province Grant [BK20130962, BK20150871]
  3. Project Fund from the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

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An efficient method for the synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids has been developed. The desired products were obtained in good to excellent yields under mild reaction conditions. The reactions were shown to proceed very fast, in most cases, within 10 min.

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