Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 38, Pages 8013-8017Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02101a
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Funding
- Recruitment Program of Global Experts (1000 Talents Plan)
- Fundamental Research Funds for the Central Universities [lzujbky-2016-153]
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A simple and practical ring-closure procedure to prepare a range of diverse heterocycles has been developed. In this transformation, a variety of substituted (thio)salicylamides and thiosalicylic acids undergo a double 1,4-addition reaction with propiolate derivatives in the presence of an inorganic base (K3PO4), as a result benzothiazinones, benzoxazinones and benzoxathiinones were prepared in good to excellent yields, respectively, even in gram scales. In addition, further transformation towards more complex structures and oxicam drug analogues has also been successfully carried out.
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