Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases

(2016) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

Enzyme replacement therapy: lessons learned and emerging questions

(2015) Agnieszka Jurecka et al.   Expert Opinion on Orphan Drugs

Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

(2014) Alberto Massarotti et al.   ChemMedChem

Pharmacological chaperone therapy for lysosomal storage diseases

(2014) Giancarlo Parenti et al.   Future Medicinal Chemistry

Selective chaperone effect of aminocyclitol derivatives on G202R and other mutant glucocerebrosidases causing Gaucher disease

(2014) Jenny Serra-Vinardell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Emerging novel concept of chaperone therapies for protein misfolding diseases

(2014) Yoshiyuki SUZUKI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Optimizing Divalent Inhibitors ofPseudomonas aeruginosaLectin LecA by Using A Rigid Spacer

(2013) Francesca Pertici et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pharmacological Chaperones as Therapeutics for Lysosomal Storage Diseases

(2013) Robert E. Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enzyme Replacement Therapy for Lysosomal Diseases: Lessons from 20 Years of Experience and Remaining Challenges

(2012) R.J. Desnick et al.   Annual Review of Genomics and Human Genetics

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

(2012) Francesca Pertici et al.   CHEMICAL COMMUNICATIONS

Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

(2012) Samarjit Patnaik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological Enhancement of α-Glucosidase by the Allosteric Chaperone N-acetylcysteine

(2012) Caterina Porto et al.   MOLECULAR THERAPY

Second-Generation Iminoxylitol-Based Pharmacological Chaperones for the Treatment of Gaucher Disease

(2011) Farah Oulaïdi et al.   ChemMedChem

Phosphatidyl myo-Inositol Mannosides Mimics Built on an Acyclic or Heterocyclic Core: Synthesis and Anti-inflammatory Properties

(2011) Sophie Front et al.   ChemMedChem

Pharmacological chaperone therapy for Gaucher disease: a patent review

(2011) Juan M Benito et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

New Glucocerebrosidase Inhibitors by Exploration of Chemical Diversity ofN-Substituted Aminocyclitols Using Click Chemistry and in Situ Screening

(2011) Lucía Díaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dependence of Avidity on Linker Length for a Bivalent Ligand–Bivalent Receptor Model System

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Looking-Glass Synergistic Pharmacological Chaperones: DGJ and L-DGJ from the Enantiomers of Tagatose

(2011) Sarah F. Jenkinson et al.   ORGANIC LETTERS

X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase

(2010) Ronnie R. Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Click Chemistry Approach to New N-Substituted Aminocyclitols as Potential Pharmacological Chaperones for Gaucher Disease†

(2010) Lucía Díaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Promising results of the chaperone effect caused by iminosugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease

(2009) Gessamí Sánchez-Ollé et al.   BLOOD CELLS MOLECULES AND DISEASES

Synthesis of Highly Functionalized Amino Acids: An Expedient Access to L- and D-β-Hydroxyenduracididine Derivatives

(2009) Clemens J. Schwörer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Mechanism of Human α-Galactosidase

(2009) Abigail I. Guce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase

(2009) Melissa R. Landon et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

(2009) Suhman Chung et al.   Nature Chemical Biology

In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

(2008) Chinami Kuriyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines

(2008) Daniel Canals et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phenotype, diagnosis, and treatment of Gaucher's disease

(2008) Gregory A Grabowski   LANCET