Article
Oncology
Elisa Kauark-Fontes, Cesar Augusto Migliorati, Joel B. Epstein, Nathaniel Simon Treister, Carolina Guimaraes Bonfim Alves, Karina Morais Faria, Natalia Rangel Palmier, Leticia Rodrigues-Oliveira, Mariana de Pauli Paglioni, Luiz Alcino Monteiro Gueiros, Karina G. M. da Conceicao Vasconcelos, Gilberto de Castro Jr, Adriana Franco Paes Leme, Marcio Ajudarte Lopes, Ana Carolina Prado-Ribeiro, Thais Bianca Brandao, Alan Roger Santos-Silva
Summary: Prophylactic extraoral PBM can delay onset of OM, reduce pain, and decrease the need for analgesics and anti-inflammatory medications, leading to improved quality of life. However, there was no evidence of PBM impacting oncological outcomes during 1 year of follow-up.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Iwona Homa-Mlak, Anna Brzozowska, Radoslaw Mlak, Aneta Szudy-Szczyrek, Teresa Malecka-Massalska
Summary: The study revealed a positive correlation between NLR and the severity of OM, with higher NLR values associated with an increased risk of more severe OM. Additionally, higher TNM stage and NLR values were identified as independent prognostic factors for survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Shiyu Liu, Qin Zhao, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: Radiation-induced oral mucositis is a common complication in head and neck cancer patients undergoing radiotherapy, leading to severe discomfort and treatment interruptions. Its pathogenesis is complex, involving the release of inflammatory transmitters. Understanding and implementing preventive measures and treatments are crucial for managing this condition effectively.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Patryk Gugnacki, Ewa Sierko
Summary: Human microbiome research is rapidly expanding in various medical and public health disciplines, showing potential in oncology for investigating the impact of oral microbiome on oncogenesis and treatment side effects. Studies indicate that the human microbiome can have oncogenic effects through various mechanisms, and that the oral microbiome plays a role in the development of head and neck cancer and radiation-induced oral mucositis. Further research is needed to better understand the structure and dynamics of the oral microbiome to develop personalized preventive measures and treatments.
Article
Biochemistry & Molecular Biology
Huiwen Xiao, Yao Fan, Yuan Li, Jiali Dong, Shuqin Zhang, Bin Wang, Jia Liu, Xingzhong Liu, Saijun Fan, Jian Guan, Ming Cui
Summary: Oral mucositis is a common complication in NOALC patients undergoing radiotherapy, and oral microbiota transplantation can alleviate the symptoms. The gut microbiota also plays a role in oral mucositis progression. Additionally, specific oral microorganisms like Lactobacillaceae could potentially serve as biomarkers for predicting NOALC prognosis after radiotherapy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Oncology
Cosimo Rupe, Gioele Gioco, Giovanni Almadori, Jacopo Galli, Francesco Micciche, Michela Olivieri, Massimo Cordaro, Carlo Lajolo
Summary: This study found a correlation between Candida spp. oral colonization prior to radiotherapy and the development of severe oral mucositis. Preventive treatment could potentially reduce the incidence of early development of severe oral mucositis.
Review
Oncology
Catrina Davy, Sharron Heathcote
Summary: The author identified three interventions: benzydamine hydrochloride mouth rinse (BHM), honey and oral glutamine (OG). BHM studies had mostly favorable results but with overall low quality and poor tolerance. Honey had mostly favorable results but weak evidence supporting the intervention for mitigating radiation-induced oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Hidenori Suzuki, Gaku Takano, Satoshi Tsukushi, Masashi Ando, Yasushi Yatabe, Takeshi Kodaira, Daisuke Nishikawa, Shintaro Beppu, Yasuhisa Hasegawa, Nobuhiro Hanai
Summary: The present study aimed to investigate the relationship between age at surgery and survival outcomes in patients with sarcoma in the head and neck. A total of 26 patients who underwent surgery for head and neck sarcoma from 2003 to 2017 were included. Patients who did not receive chemotherapy were significantly older at the time of surgery. Receiver operating curve analysis determined 55 years as the cutoff age for predicting death. Older age was associated with shorter overall, disease-specific, local recurrence-free, and disease-free survival rates. Multivariate analysis using Cox's proportional hazards model adjusted for chemotherapy (absence/presence) showed that age (>= 55 years/<55 years) was correlated with shorter overall survival. In conclusion, older age predicts worse overall survival in patients with head and neck sarcoma.
Article
Multidisciplinary Sciences
Kanade Ito, Shiori Tokura, Itsuki Takazawa, Naomi Yoshida, Tohko Nakanishi, Kikue Akiyama, Yuki Onuma, Toshiko Adachi, Hiroyuki Harada, Hitomi Nojima, Masahiko Miura, Ryoichi Yoshimura, Yuji Kabasawa
Summary: This retrospective analysis found that Episil (R) can effectively relieve pain in oral mucositis (OM) caused by radiotherapy or chemoradiotherapy in head and neck cancer patients. However, medical professionals need to pay careful attention to each patient.
Article
Oncology
Isabel Schaussltz Pereira Faustino, Maria Georgaki, Alan Roger Santos-Silva, Pablo Agustin Vargas, Marcio Ajudarte Lopes
Summary: Radiotherapy as an adjuvant treatment for malignant head and neck tumors can lead to various toxicities, including the little explored and understood late effect of oral mucosa necrosis. This case report presents a 53-year-old diabetic man with oral mucositis and tissue necrosis after radiotherapy, who showed good response to photobiomodulation therapy. The limited descriptions of radiotherapy-related soft tissue necrosis make this case valuable in expanding knowledge on this important topic.
Review
Chemistry, Medicinal
Juliana Borges de Lima Dantas, Tila Fortuna Costa Freire, Ana Carla Barletta Sanches, Erielma Lomba Dias Juliao, Alena Ribeiro Alves Peixoto Medrado, Gabriela Botelho Martins
Summary: This study aimed to evaluate the efficacy of topical chamomile in preventing and treating oral mucositis (OM) in cancer patients. The systematic review found that topical chamomile was effective in preventing and treating OM in four out of six studies. However, the study had some limitations, such as the lack of information on the minimum age of patients. Further research is needed to determine the protocols for the use of this phytotherapy in the oncology population.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Atsushi Musha, Chika Hirai, Yoko Kitada, Anna Tsunoda, Hirofumi Shimada, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Hiro Sato, Kohei Okada, Akiko Adachi, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno
Summary: This study aimed to investigate the relationship between oral bacterial counts and oral mucositis during carbon ion radiotherapy in patients with head and neck cancer. The study found that oral bacterial counts gradually increased during carbon ion radiotherapy and peaked at 16 fractions. Patients with higher bacterial counts tended to experience faster-onset mucositis and slower healing.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Jinlong Wei, Jie Wu, Huanhuan Wang, Bin Wang, Tingting Zhao, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: Episil(R) effectively improved oral mucositis and malnutrition in head and neck cancer patients undergoing radiotherapy, reducing the incidence of high-level OM and showing better results in terms of weight, BMI, and albumin levels.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Medicinal
Saba Safarzadeh, Farinaz Shirban, Mohammad Bagherniya, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Cancer therapy-induced oral mucositis is a troublesome complication after radio-chemotherapy, and factors such as age, nutritional status, tumor type, oral hygiene, treatment method, and oxygen-free radicals can affect its incidence. Herbal medicine has been suggested as a potential alternative due to its unique properties of safety, availability, and low cost, with anti-inflammatory, anti-microbial, and antioxidative activities being essential for its palliative effects on oral mucositis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Ghanyah Al-Qadami, Joanne Bowen, Ysabella Van Sebille, Kate Secombe, Mohsen Dorraki, Johan Verjans, Hannah Wardill, Hien Le
Summary: This study aimed to uncover associations between an individual's pre-therapy gut microbiota and the severity of radiotherapy-induced oral mucositis (OM) as well as recurrence risk in patients with head and neck cancer (HNC). The results showed that the composition of the gut microbiota was associated with the severity of OM and the risk of HNC recurrence.
SUPPORTIVE CARE IN CANCER
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Daniel Cohen Goldemberg, Andreia Cristina de Melo, Livia Cristina de Melo Pino, Heliton Spindola Antunes, Jair Carneiro Leao, Stephen Porter
Article
Dentistry, Oral Surgery & Medicine
Ana Carolina da Silva Souto, Fernanda Vieira Heimlich, Leticia Lima de Oliveira, Anke Bergmann, Fernando Luiz Dias, Heliton Spindola Antunes, Andreia Cristina de Melo, Luiz Claudio Santos Thuler, Daniel Cohen Goldemberg
Summary: This study retrospectively analyzed the epidemiological characteristics and specific survival of patients diagnosed with tongue squamous cell carcinoma at the National Cancer Institute. The results showed that the majority of patients were male, smokers, alcohol consumers, had low education, and were diagnosed at an advanced stage, with poor specific survival.
Article
Otorhinolaryngology
Andressa Silva de Freitas, Izabella C. Santos, Cristina Furia, Rodrigo Dornelas, Ana Catarina Alves e Silva, Fernando Luiz Dias, Gil F. Salles
Summary: This study evaluated late and asymptomatic patients after open partial horizontal laryngectomy (OPHL) and found that dysphagia is common in these patients. Older age, lower preoperative serum albumin levels, greater postoperative weight loss, and diabetes are associated with a higher risk of severe dysphagia in the late period after OPHL.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Andressa Silva de Freitas, Guilherme Maia Zica, Mariana Salles, Ana Catarina Alves E Silva, Thiago Huaytalla Silva, Fernando Luiz Dias, Izabella Costa Santos
Summary: The study investigated and compared the relationship between self-reported quality of life and objective assessments of swallowing function in patients undergoing SCL CHEP. The findings showed that swallowing function is crucial for quality of life, with residue potentially being more important than aspiration.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Leandro Luongo Matos, Renato Castro Capuzzo, Paola Andrea Galbiatti Pedruzzi, Terence Farias, Jose Wilson Mourao de Farias, Carlos Takahiro Chone, Hugo Fontan Kohler, Jose Guilherme Vartanian, Fernando Luiz Dias, Eduardo Vieira Couto, Fabio Roberto Pinto, Andre Lopes Carvalho, Luiz Paulo Kowalski
Summary: In a real-world scenario, sentinel lymph node biopsy is shown to be accurate and safe for patients with early lip and oral cavity squamous cell carcinoma, with similar results to elective neck dissection.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Rodrigo Otavio Araujo, Fernando Meton Vieira, Ana Paula Victorino, Claudia Torres, Ivanir Martins, Simone Guaraldi, Marcus Valadao, Eduardo Linhares, Carlos Gil Ferreira, Luiz Claudio Thuler
Summary: This study aimed to compare the impact of two different neoadjuvant chemoradiotherapy (neoCRT) regimens on the quality of life (QOL) in patients with locally advanced rectal cancer. The results showed that the QOL was equivalent between the two treatment groups after neoCRT, with the exception of better micturition problems, gastrointestinal problems, defecation problems, and sexual satisfaction in the capecitabine group. Overall, the QOL improved after neoCRT but decreased following rectal resection, returning to basal levels at late evaluation. Fecal incontinence was high after sphincter preservation.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Andres Coca-Pelaz, Juan P. Rodrigo, Fernando Lopez, Jatin P. Shah, Carl E. Silver, Abir Al Ghuzlan, C. Willemien Menke-van der Houven Van Oordt, Robert C. Smallridge, Ashok R. Shaha, Peter Angelos, William M. Mendenhall, Cesare Piazza, Kerry D. Olsen, June Corry, Ralph P. Tufano, Alvaro Sanabria, Sandra Nuyts, Cherie-Ann Nathan, Vincent Vander Poorten, Fernando Luiz Dias, Carlos Suarez, Nabil F. Saba, Pim de Graaf, Michelle D. Williams, Alessandra Rinaldo, Alfio Ferlito
Summary: Anaplastic thyroid cancer is a deadly disease with limited treatment options. Recent advancements in personalized medicine and combination therapy have shown promising results, particularly in targeting specific genetic profiles. Although average survival has improved, there is still a need for further improvement.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Review
Oncology
Paula Fatturi Moretz-sohn, Fernando Luiz Dias, Caroline Mafra de Carvalho Marques
Summary: The purpose of this study is to clarify the incidence, epidemiology, predictive factors, and outcome-based survival in a large cohort of patients with minor salivary gland carcinomas (MiSGC) of the head and neck treated at the Brazilian National Cancer Institute (BNCI) over a 20-year period by comparing and associating the results of current articles on the world stage.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Health Care Sciences & Services
Marina Kelner, Bruna Carvalho da Silva, Tatiane Montella, Pedro Nazareth Aguiar, Gilberto Lopes, Carlos G. Ferreira, Pedro De Marchi
Summary: This study compares the cost of treating advanced lung cancer in Brazil with the reimbursement provided by the Brazilian public healthcare system. It finds that the cost of the best treatment available is significantly higher than the amount reimbursed by the system.
VALUE IN HEALTH REGIONAL ISSUES
(2023)
Article
Oncology
Lilian Faroni, Carlos Gil Ferreira, Fabio Moraes, Clarissa Baldotto, Mauro Zukin, Veronica Aran, Luiz Henrique Araujo
Summary: The study examined the real-world outcomes of using SBRT for lung lesions in a Brazilian institution. The results showed that SBRT was effective in achieving high local control rates and had acceptable toxicity for treating malignant lung lesions in Latin America.
JCO GLOBAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Adrianus Johannes de Langen, Melissa L. Johnson, Julien Mazieres, Anne -Marie C. Dingemans, Giannis Mountzios, Miklos Pless, Jurgen Wolf, Martin Schuler, Herve Lena, Ferdinandos Skoulidis, Yasuto Yoneshima, Sang-We Kim, Helena Linardou, Silvia Novello, Anthonie J. van der Wekken, Yuanbin Chen, Solange Peters, Enriqueta Felip, Benjamin J. Solomon, Suresh S. Ramalingam, Christophe Dooms, Colin R. Lindsay, Carlos Gil Ferreira, Normand Blais, Cynthia C. Obiozor, Yang Wang, Bhakti Mehta, Tracy Varrieur, Gataree Ngarmchamnanrith, Bjorn Stollenwerk, David Waterhouse, Luis Paz-Ares
Summary: This study compared the efficacy and safety of Sotorasib with standard-of-care treatment in patients with non-small-cell lung cancer (NSCLC) with the KRASG12C mutation. The results showed that compared to docetaxel, Sotorasib significantly increased progression-free survival and had a more favorable safety profile.
Article
Oncology
Giovanni Succo, Andy Bertolin, Izabela Costa Santos, Martina Tascone, Marco Lionello, Marco Fantini, Andressa Silva de Freitas, Ilaria Bertotto, Andrea Elio Sprio, Giuseppe Sanguineti, Fernando Luiz Dias, Giuseppe Rizzotto, Erika Crosetti
Summary: A study of 134 cases of T4a laryngeal cancer treated with OPHL+/- PORT was conducted, showing that OPHL can be a viable option in selected pT4a LC patients who refuse total laryngectomy.
Article
Otorhinolaryngology
Bruno Albuquerque Sousa, Fernando Luiz Dias, Marcus A. Acioly de Sousa, Marco Antonio Pinto, Jessica Marquet Silva, Claudio Roberto Cernea
Summary: This study compared the outcomes of microvascular flap reconstruction of mid-face and scalp oncologic defects using superficial temporal and cervical vessels as recipient vessels. The results showed that the patients with superficial temporal recipient vessels had a higher rate of flap loss compared to those with cervical recipient vessels, but the difference was not statistically significant.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Health Care Sciences & Services
Flavia Amaral Duarte, Pedro Nazareth Aguiar Junior, Rodrigo Dienstmann, Carlos Gil Ferreira
Summary: Precision medicine provides personalized interventions based on patients' or tumors' characteristics, but it faces challenges in becoming a global reality, with the main issue being inequities in access to genomic testing. Disparities exist between regions and populations, and socioeconomic factors play a significant role in this inequality.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Endocrinology & Metabolism
Terence Farias, Luiz Paulo Kowalski, Fernando Dias, Carlos S. Ritta Barreira, Jose Guilherme Vartanian, Marcos Roberto Tavares, Fernanda Vaisman, Denise Momesso, Alexandre Ferreira Oliveira, Rodrigo Nascimento Pinheiro, Heber Salvador de Castro Ribeiro
Summary: The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Recommendations were developed based on research of scientific articles and guidelines from international medical societies. The guidelines offer recommendations on when to perform neck dissection, the extent of dissection, and the use of molecular tests.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
