Journal
OPTICS LETTERS
Volume 42, Issue 11, Pages 2145-2148Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.42.002145
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Funding
- National Natural Science Foundation of China (NSFC) [61331001, 61627827, 81630046, 91539127]
- Science and Technology Planning Project of Guangdong Province, China [2014A020215031, 2014B020215003, 2015B020233016]
- Distinguished Young Teacher Project in Higher Education of Guangdong, China [YQ2015049]
- Ph.D. Start-up Fund of Natural Science Foundation of Guangdong Province [S82088]
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Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by alloptically integrated photoacoustic and optical coherence tomography (AOPA/OCT). The imaging capability of the AOPA/OCT was verified by the mimic phantoms. Furthermore, in vivo characterization of vasculatures and tissue structures from BCC and MM mice were successfully achieved with high resolution. Results prove the feasibility of AOPA/OCT as a novel method to dedicate to the in vivo biopsy of skin cancers which shows new insights into the study of skin diseases in early stages. (C) 2017 Optical Society of America
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