Article
Pathology
Chunxiu Hu, Jianxiang Wu, Li Wang, Xuewu Liu, Bin Da, Yi Liu, Lingyan Huang, Qin Chen, Yuefang Tong, Zhongyu Jiang
Summary: The study revealed that CDCA8 was overexpressed in LUAD tissues while its upstream miRNA miR-133b was downregulated, and miR-133b could inhibit the proliferation, invasion, and migration of LUAD cells by targeting CDCA8.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Sana Abdul Khaliq, Zobia Umair, Mi-Ock Baek, Seung Joo Chon, Mee-Sup Yoon
Summary: The level of C-peptide is critical for the migration of undecidualized endometrial stromal cells and is associated with the failure rate of trophoblast invasion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Qiaoxi Xia, Zepeng Du, Mantong Chen, Xiao Zhou, Wenjing Bai, Xiaoqi Zheng, Ling Lin, Yan Zhao, Jiyu Ding, Zhisheng Wu, Haiying Zou, Shaohong Wang, Liyan Xu, Enmin Li, Bingli Wu
Summary: During malignant tumour development, the LCN2/LOXL2/MMP9 ternary complex promotes migration, invasion, and malignant progression of cancer cells through multiple mechanisms, making it a potential therapeutic target.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Cell Biology
Boqiang Liu, Yuanshi Tian, Mingyu Chen, Hao Shen, Jiafeng Xia, Junjie Nan, Tingting Yan, Yifan Wang, Liang Shi, Bo Shen, Hong Yu, Xiujun Cai
Summary: This study identified a novel circRNA, circUBAP2, in hepatocellular carcinoma (HCC) through bioinformatics analysis. CircUBAP2 was significantly upregulated in HCC tissues and correlated with aggressive clinical characteristics and poor prognosis. Functionally, circUBAP2 promoted cell proliferation, colony formation, migration, and invasion in vitro, and enhanced tumor growth and pulmonary metastasis in vivo. Mechanistically, circUBAP2 acted as a competing endogenous RNA (ceRNA) for miR-194-3p, thereby regulating the expression of MMP9 and promoting HCC progression. CircUBAP2 could potentially serve as a prognostic biomarker and therapeutic target for HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Libing Wang, Mingxin Cui, Daming Cheng, Fengzhi Qu, Jingkun Yu, Yanbin Wei, Ling Cheng, Xiaotang Wu, Xiaogang Liu
Summary: The study revealed that miR-9-5p is highly expressed in HCC cells while ESR1 is poorly expressed; overexpression of miR-9-5p can enhance cell proliferation, invasion, and migration; ESR1 is identified as a downstream target of miR-9-5p in HCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Lingling Jiang, Xuexin Wang
Summary: miR-133b inhibits the proliferation, invasion, and migration of cervical cancer cells by suppressing the expression of ARFGEF1, suggesting that miR-133b/ARFGEF1 could be a potential therapeutic target for cervical cancer.
Article
Cell Biology
Jiwei Cheng, Haibo Ma, Ming Yan, Wenqun Xing
Summary: THAP9-AS1 is overexpressed in esophageal squamous cell carcinoma (ESCC) and is positively correlated with tumor size, TNM stage, lymph node metastasis, and prognosis. It functions as a competing endogenous RNA (ceRNA) for miR-133b, leading to the upregulation of SOX4 and promoting ESCC progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Shasha Zhu, Xiangbing Kong, Mengru Song, Mingyang Chi, Yitong Liu, Peng Zhang, Qiao Zhang, Pingping Shang, Feifei Feng
Summary: miR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qingqing Yan, Lin Jia, Biyan Wen, Yao Wu, Yanbo Zeng, Qing Wang
Summary: The study found that C. butyricum could protect against pancreatic and intestinal injury after SAP via downregulation of MMP9 in vitro and in vivo. However, the effects of C. butyricum on MMP9 knockout cells were not significant. These results suggest that gut microbiota may influence intestinal injury during SAP by modulating MMP9.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Kai Zhu, Jinlan Lin, Shengjia Chen, Qian Xu
Summary: The study revealed that miR-9-5p promotes LUAD cell progression by targeting ID4, potentially becoming a molecular target for LUAD.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Jianwen Mo, Tiansheng Zheng, Li Lei, Peng Dai, Jun Liu, Huabin He, Jin Shi, Xi Chen, Tianting Guo, Bin Yuan, Guanglin Ji
Summary: Overall, this study demonstrated that miR-1253 is downregulated in OS cells and can suppress the proliferation, migration, and invasion of OS cells. It functions by inhibiting the expression of the downstream target gene MMP9 through direct binding, thereby affecting OS cell functions. MiR-1253 shows potential as a biomarker and therapeutic target for OS therapy.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Geriatrics & Gerontology
Chuan Ze Liu, Da Shuai Guo, Jian Jun Ma, Lin Rui Dong, Qing Qing Chang, Hong Qi Yang, Ke Ke Liang, Xiao Huan Li, Da Wei Yang, Yong Yan Fan, Qi Gu, Si Yuan Chen, Dong Sheng Li
Summary: This study found that serum MMP3 levels were lower and MMP9 levels were higher in patients with Parkinson's disease (PD) compared to healthy controls. Serum MMP3 levels were correlated with non-motor symptoms and sleep disturbance in PD patients, while MMP9 levels were correlated with non-motor symptoms and cognitive function in PD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Oncology
Tianyu Wang, Yuanyuan Zhang, Jianhao Bai, Yawen Xue, Qing Peng
Summary: The study revealed that MMP1, MMP9, and other matrix metalloproteinases were upregulated in UVM tissues and correlated with disease progression and patient survival. Additionally, 18 transcription factors associated with MMPs were identified, potentially providing biomarkers and targets for UVM. Further studies are needed to confirm these findings.
Article
Pathology
Qi Qi, Chen Chen, Chang Liu, Bin Zhang, Yuchen Ma, Hua Zhang, Wuhao Huang, Changli Wang
Summary: The study demonstrated that linc8087 is downregulated in NSCLC and is significantly associated with poor survival. Overexpression of linc8087 inhibits cell migration and invasion, while its knockdown promotes cell migration and invasion. The findings suggest that linc8087 plays a key role in NSCLC progression and may serve as a meaningful prognostic biomarker and potential therapeutic target.
PATHOLOGY RESEARCH AND PRACTICE
(2021)