Article
Integrative & Complementary Medicine
Yong Zhang, Zhengxia Zha, Wenhua Shen, Dan Li, Naixin Kang, Zhong Chen, Yanli Liu, Guoqiang Xu, Qiongming Xu
Summary: The study demonstrated that anemoside B4 ameliorated TNBS-induced colitis symptoms by inhibiting tissue damage, inflammatory cell infiltration, pro-inflammatory cytokine production, apoptosis, and slowed proliferation in colon. Quantitative proteomic analyses revealed that anemoside B4 significantly altered 56 proteins in TNBS-induced rats, with a focus on proteins related to TCA cycle and respiratory electron transport chain. S100A9, one of the most significantly down-regulated proteins, was associated with NF-kappa B and MAPK signaling pathways in UC pathogenesis.
Article
Multidisciplinary Sciences
Akira Nakazato, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Keitaro Fujii, Satoshi Saijoh, Shinkichi Morita, Tomoko Yamazaki, Takayuki Imai, Ikuro Sato, Kennichi Satoh, Kazunori Yamaguchi, Kazuo Sugamura, Jun Yasuda, Kazuto Matsuura, Hideo Shojaku, Yukinori Asada, Keiichi Tamai
Summary: This study found that RELA, a subunit of nuclear factor kappaB, is critical for the transcription of CD271 in hypopharyngeal cancer cells. RELA promotes CD271 transcription in squamous cell carcinoma cell lines, but not in normal epithelium and neuroblastoma cell lines. The specific region + 957 to + 1138 within the CD271 promoter sequence is important for RELA binding.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Zheng-xia Zha, Yu Lin, Ke-xin Wang, Yan-lin Zhang, Dan Li, Guo-qiang Xu, Qiong-ming Xu, Yan-li Liu
Summary: The study found that Hederacoside C (HSC) can improve colitis by repairing damaged intestinal barrier through regulating S100A9/MAPK and neutrophil recruitment.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Immunology
Soudeh Ghafouri-Fard, Mahdi Gholipour, Atefe Abak, Mehrdokht Mazdeh, Mohammad Taheri, Arezou Sayad
Summary: The study showed significant differences in the expressions of NF-kappa B-related lncRNAs between PD patients and healthy controls, with certain gene expressions being associated with the pathogenesis of PD and correlated with each other. Among the evaluated genes, CEBPA demonstrated the best performance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Matthew Martin, Mengyao Sun, Aishat Motolani, Tao Lu
Summary: This article provides an overview of colorectal cancer (CRC) and its stages, types of biomarkers, signaling pathways related to CRC, and the significant role of NF-kappa B in CRC. The authors suggest that more ideal NF-kappa B inhibitors may be developed with the discovery of novel regulators of the pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Dimitra P. Vageli, Sotirios G. Doukas, Panagiotis G. Doukas, Benjamin L. Judson
Summary: Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been recognized as a risk factor for hypopharyngeal cancer development, with bile acids playing a crucial role in promoting inflammatory and neoplastic changes in the upper aerodigestive tract. NF-kappa B and STAT3 have been identified as key mediators in the early oncogenic molecular events associated with acidic bile refluxate.
Article
Oncology
Hongying Zhou, Dan Su, Yun Chen, Yiwen Zhang, Ping Huang
Summary: The study found that the potassium voltage-gated channel subfamily D (KCND) channels, particularly KCND2, play a role in the occurrence and development of gastric cancer. KCND2 is highly expressed in gastric cancer and is associated with different tumor grades, T stages, and N stages. It is also an independent predictor of poor prognosis. Mechanistically, KCND2 promotes the proliferation of gastric cancer cells and the infiltration of M2 macrophages through activation of NF-κB.
Review
Chemistry, Medicinal
Rina Das, Dinesh Kumar Mehta, Meenakshi Dhanawat
Summary: Nuclear factor-kappa B (NF-kappa B) is a transcription factor that controls gene expression and plays a crucial role in regulating cell signaling. The constitutive activity of NF-kappa B signaling has been reported in various cancer cells, making it a desirable target for cancer treatment. Plant-derived compounds, such as flavonoids and polyphenols, have been evaluated as potential inhibitors of NF-kappa B signaling and have shown promising anticancer effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Biochemistry & Molecular Biology
Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju
Summary: NF-kappa B is a major regulator of the biological characteristics of tumor cells, and antioxidants or protease inhibitors may suppress colorectal cancer. Computational studies suggest NF-kappa B could be a potential target for anti-cancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Analytical
Kanyu Xun, Yue Sun, Qiang Zhang, Nachuan Wen, Zhimin Wang, Liping Qiu, Weihong Tan
Summary: This study developed a new nanoplatform using streptavidin as a carrier to directly analyze and manipulate the activity of target proteins. By incorporating a photoresponsive module, the nanoplatform was able to control the nuclear translocation behavior of active proteins and regulate downstream signaling events.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Linlin Zhang, Lei Cheng, Zhemeng Chen, Yi Fang, Changjiang Li, Min Chen, Peijie He, Haitao Wu, Jianzhang Wu, Jian Chen
Summary: The compound L42H17 has shown potential as a candidate drug for the treatment of hypopharyngeal carcinoma due to its ability to inhibit cell growth and metastasis via multiple pathways.
JOURNAL OF DRUG TARGETING
(2023)
Article
Immunology
Jiawei Liu, Ning Fu, Zhenbang Yang, Ang Li, Hongjiao Wu, Ye Jin, Qinqin Song, Shanshan Ji, Hongxue Xu, Zhi Zhang, Xuemei Zhang
Summary: This study evaluates the expression of CD55 in colon cancer and investigates its regulation by transcription factors and miRNA. The results indicate that CD55 is regulated by TFCP2, NF-kappa B, miR-27a-3p, and several immune-related genes, which in turn affects the development of colon cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Wenqing Li, Fubo Han, Kaifan Tang, Chengjie Ding, Fen Xiong, Yina Xiao, Chen Li, Qian Liang, Kwang Youl Lee, Ik-Soo Lee, Hongchang Gao
Summary: Demethylzeylasteral exhibits promising potential as a treatment for colon cancer by inhibiting S100A11 expression and directly interacting with it to attenuate cell proliferation. NF-kappa B acts as an upstream transcription factor regulating S100A11 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Enrico Mossotto, Joanna Boberska, James J. Ashton, Imogen S. Stafford, Guo Cheng, Jonathan Baker, Florina Borca, Hang T. T. Phan, Tracy F. Coelho, R. Mark Beattie, Sandrine P. Claus, Sarah Ennis
Summary: A metabolomic signature of inflammation can be detected from blood plasma in CD patients. This signature is correlated with pro-inflammatory immune response genes carrying pathogenic mutations.
SCIENTIFIC REPORTS
(2022)