Article
Multidisciplinary Sciences
Tianying Zheng, Wenfei Han, Aijun Wang, Yonggang Wang
Summary: This study reveals that miR-128-3p inhibits epithelial-mesenchymal transition, invasion, and migration of pancreatic cancer cells by targeting ZEB1.
Article
Biotechnology & Applied Microbiology
Huiming Zhang, Shuang Liu, Liqiang Chen, Yanliang Sheng, Wenzhe Luo, Gang Zhao
Summary: miR-509-3p inhibits the proliferation, migration, invasion, and EMT of HCC cells by negatively regulating Twist, thereby suppressing HCC development and metastasis.
Review
Biochemistry & Molecular Biology
Andrea Abaurrea, Angela M. Araujo, Maria M. Caffarel
Summary: Epithelial-mesenchymal plasticity (EMP) is crucial in cancer development, promoting the acquisition of mesenchymal features in cancer cells through cytokine signal transduction pathways, such as the interleukin 6 (IL-6) family. However, the effect may depend heavily on the context.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wei-Dong Li, Hai-Tao Wang, Yue-Ming Huang, Bo-Hao Cheng, Li-Jun Xiang, Xin-Hao Zhou, Qing-Yan Deng, Zhi-Gang Guo, Zhi-Feng Yang, Zhi-Fen Guan, Yao Wang
Summary: The downregulation of circ_0003356 and the upregulation of miR-668-3p were observed in gastric cancer cells. Overexpression of circ_0003356 inhibited the migration, proliferation, and invasion of gastric cancer cells and promoted apoptosis. Through its interaction with miR-668-3p, circ_0003356 regulated the biological behaviors of gastric cancer cells, with SOCS3 as a downstream target of miR-668-3p.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Yang Liu, Jingwen Wang, Jianwen Chen, Shaoshuai Wu, Xianhuang Zeng, Qiushuang Xiong, Yandan Guo, Junwei Sun, Feifei Song, Jiaqi Xu, Sen Yuan, Chuang Li, Yuan He, Ming Wang, Lang Chen, Yun-Bo Shi, Mingxiong Guo, Deyin Guo, Guihong Sun
Summary: Hepatitis B virus (HBV) infection enhances the expression of miR-520c-3p, which promotes the development and progression of hepatocellular carcinoma (HCC) by inducing epithelial-mesenchymal transition (EMT) and activating the AKT-NFKB signaling pathway through targeting PTEN. The inhibition of miR-520c3p with antagomir significantly represses the invasiveness of HBx-induced HCC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mei-Chuan Kuo, Wei-An Chang, Ling-Yu Wu, Yi-Chun Tsai, Ya-Ling Hsu
Summary: Hypoxia-induced epithelial-to-mesenchymal transition (EMT) in proximal tubular epithelial cells (PTECs) is modulated by miR-545-3p-TNFSF10 interaction. TNFSF10 attenuates EMT induced by hypoxia in PTECs. These findings provide new insights into the unique regulation of miR-545-3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia.
Article
Biochemistry & Molecular Biology
Moamen Masalha, Tal Meningher, Adi Mizrahi, Aviv Barzilai, Hilla Tabibian-Keissar, Devorah Gur-Wahnon, Iddo Z. Ben-Dov, Joshua Kapenhas, Jasmine Jacob-Hirsch, Raya Leibowitz, Yechezkel Sidi, Dror Avni
Summary: Cutaneous squamous cell carcinoma (CSCC) is a skin cancer that evolves from normal epidermis and is characterized by the disruption of cell-cell contacts and acquisition of a mesenchymal motile phenotype. The decreased expression of miR-199a-3p plays a crucial role in this process by targeting RAP2B and inhibiting the epithelial-to-mesenchymal transition (EMT). Inhibitors of RAP2B or FAK may be potential therapeutic agents for CSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Bin Lu, Xiaohui Cao, Xinhua Chen, Yan Yue, Shiqing Tang, Fei Xia
Summary: The study aimed to clarify the regulatory mechanism of miR-518c-3p in the progression of endometriosis. The results demonstrated that miR-518c-3p inhibits the growth, metastasis, and EMT of ESCs by targeting ZNF608, thereby reducing the ectopic endometrial area in rats with EMs.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yong Liu, Yuelin Liu, Yong Gao, Lei Wang, Hengliang Shi, Chengmin Xuan
Summary: This study identified the regulatory pathway of H19 and hsa-miR-338-3P in regulating NRP1 expression in GBM, which plays an important role in the disease.
Article
Medicine, Research & Experimental
Jian Ma, Fan-Fei Kong, Di Yang, Hui Yang, Cuicui Wang, Rong Cong, Xiao-Xin Ma
Summary: EMT promotes tumorigenesis and metastasis while increasing tumor tolerance to treatment. MIR210HG overexpression in endometrial cancer tissues is associated with poor prognosis, and its regulation of the miR-337-3p/137-HMGA2 axis suggests potential as a therapeutic target for endometrial cancer.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoxu Liu, Jing Wu, Bo Yang, Yuanyuan Zhao, Yafan Wang, Shuhong Pan, Suibing Miao, Xiaohua Wu
Summary: This study found that the hsa_circ_0005991/miR-30b-3p/Cdc42EP1 axis promotes the epithelial-mesenchymal transition process in endometriosis, providing a theoretical basis for the mechanism exploration and therapy of this disease.
Article
Oncology
Chen-hui Bao, Lin Guo
Summary: This study found that miR-27b-3p is down-regulated in gastric cancer and affects epithelial-mesenchymal transition and cell invasion and migration by regulating the Hippo pathway and inhibiting the expression of RUNX1.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
Jing Wan, Min Huang
Summary: Apigenin inhibits proliferation, migration, invasion, and EMT of glioma cells through activation of miR-103a-3p and targeting the NEDD9/FAK/AKT pathway.
FOOD SCIENCE AND TECHNOLOGY
(2022)