Article
Biochemistry & Molecular Biology
Da-Wei Li, Min Liu, Yue-Qi Leng, Jin-Fang Hu, Sa Deng, Ai-Jing Leng, Xiao-Chi Ma, Ruo-Yu Wang, Jian Zhou, Chao Wang
Summary: This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Article
Multidisciplinary Sciences
Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Ahmad Gholami, Navid Omidifar, Wei-Hung Chiang, Vijayakameswara Rao Neralla, Khadije Yousefi, Mansoureh Shokripour
Summary: This study provides detailed characterization of Ganoderma lucidum methanolic extract (GLME) and demonstrates its antimicrobial and cytotoxic properties. The results indicate stronger anticancer activity against blood cancer cells compared to breast cancer cells, with lower toxicity on normal cells.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
M. A. Oke, F. J. Afolabi, O. O. Oyeleke, T. A. Kilani, A. R. Adeosun, A. A. Olanbiwoninu, E. A. Adebayo
Summary: Ganoderma lucidum, also known as Lingzhi, is a medicinal mushroom used in traditional medicine for various health benefits. It contains a wide range of bioactive compounds, including triterpenoids and polysaccharides, which have been shown to possess numerous pharmacological activities. Studies have demonstrated the potential of Ganoderma lucidum in disease prevention and treatment, leading to the development of various formulations and products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Yu-Xin Lin, Jin-Tao Sun, Zheng-Zheng Liao, Yan Sun, Xiang-Ge Tian, Ling-Ling Jin, Chao Wang, Ai-Jing Leng, Jian Zhou, Da-Wei Li
Summary: Four new lanostane triterpenoids were isolated from the fruiting bodies of Ganoderma lucidum, which showed potential application for anti-neuroinflammation by inhibiting the activity of FAAH without cytotoxicity.
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Xiaoxu Gao, Guoqing Long, Yongcheng Yang, Gang Chen, Guoli Hou, Xuting Huo, Jingming Jia, Anhua Wang, Gaosheng Hu
Summary: This study isolated and identified 10 undescribed lanostane triterpenoids and 21 known compounds from statically cultured mycelial mat of G. lucidum. The hepatoprotective activities of these compounds in H2O2-induced HepG2 cells were evaluated, and the structure-activity relationship was discussed.
Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Ming Cai, Hua Mu, Haoyong Xing, Zhenhao Li, Jing Xu, Wei Liu, Kai Yang, Peilong Sun
Summary: The study found that Ganoderma lucidum spores with the sporoderm removed showed stronger metabolic promotion effects and better anti-inflammatory properties after in vitro digestion.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Juan Xu, Yiyi Wang, Yi Zhang, Kehui Xiong, Xiaoyun Yan, Shiyu Ruan, Xueqian Wu
Summary: In this study, a transcription factor GlbHLH5 was identified for the first time as a potential regulator of Ganoderma triterpenoids biosynthesis. It was found that GlbHLH5 could positively regulate triterpenoids biosynthesis by activating the synergistic expression of key enzyme genes in the biosynthetic pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emin Cadar, Ticuta Negreanu-Pirjol, Carolina Pascale, Rodica Sirbu, Irina Prasacu, Bogdan-Stefan Negreanu-Pirjol, Cezar Laurentiu Tomescu, Ana-Maria Ionescu
Summary: This review examines the scientific research on the natural bioactive compounds found in extracts of Ganoderma lucidum (G. lucidum) and their potential in cancer treatment. The study reveals that G. lucidum contains important bioactive compounds such as polysaccharides, triterpenoids, and sterols, which have demonstrated multiple anticancer effects including immunomodulatory, anti-proliferative, cytotoxic, and antioxidant actions. However, there is still uncertainty about the effects of G. lucidum bioactive compounds in treating different types of cancer, and further clinical trials are needed to clarify their potential benefits in cancer prevention and treatment.
Article
Microbiology
Ling Sun, Li-Ping Liu, Ya-Zhen Wang, Lei Yang, Cunsheng Zhang, Mei-Xiang Yue, Mokhtar Dabbour, Benjamin Kumah Mintah, Liang Wang
Summary: This study investigated the effect of ultrasonication on the liquid fermentation of Ganoderma lucidum, showing significant changes in metabolic and transcriptional levels. Ultrasonication induced more metabolites biosynthesis and lasting influence on gene expression in mycelia. The enhanced triterpenoids production of G. lucidum by up-regulating terpenoids synthase genes suggests ultrasound as an efficient approach for producing more metabolites.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jiajia Wang, Junfeng Pu, Zhixian Zhang, Zean Feng, Jing Han, Xiaojie Su, Lei Shi
Summary: This study evaluated the anti-tumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice. The results showed that TGL had inhibition rates higher than 40% in tumor bearing mice. TGL had protective effects on the spleen and thymus, improved lipid peroxidation, down-regulated Bcl-2, upregulated Bax, and improved gut microbiota.
Article
Cardiac & Cardiovascular Systems
Yanhong Li, Jun Tang, Hongling Gao, Yanfeng Xu, Yunlin Han, Haiquan Shang, Yaozeng Lu, Chuan Qin
Summary: The study comprehensively evaluated the effect of GLTs and GLPs on atherosclerosis in vivo and in vitro, finding that GL treatment significantly reduced lipid levels and aortic plaque area. Moreover, GL attenuated endothelial dysfunction and inflammatory polarization of macrophages, thus slowing the progression of atherosclerosis.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Food Science & Technology
Aijun Tong, Weihao Wu, Zhengxin Chen, Jiahui Wen, Ruibo Jia, Bin Liu, Hui Cao, Chao Zhao
Summary: It has been found that Ganoderma lucidum triterpenoids aid in the prevention and improvement of hyperlipidemia by modulating the gut microbiota. The experiment showed that supplementation with Ganoderma lucidum triterpenoids significantly reduced serum lipid levels and reversed the dysbiosis of gut microbiota in rats with high-fat diet-induced hyperlipidemia.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Mohammed Sharif Swallah, Precious Bondzie-Quaye, Yahui Wu, Adolf Acheampong, Frederick Leo Sossah, Shereen M. M. Elsherbiny, Qing Huang
Summary: Ganoderma lucidum (G. lucidum) is a traditional Asian medicine with a long history, known for its health-improving and life-extending properties. It contains bioactive metabolites such as polysaccharides, triterpenoids, and polyphenols, which have antioxidant, anti-inflammatory, anticancer, hepatoprotective, and antidiabetic activities. This mushroom species is widely used in the food industry as a nutrient supplement.
Article
Nutrition & Dietetics
Xue Mi, Gui-Rong Zeng, Jie-Qing Liu, Zhou-Song Luo, Ling Zhang, Xiao-Man Dai, Wen-Ting Fang, Jing Zhang, Xiao-Chun Chen
Summary: This study found that Ganoderma lucidum triterpenoids (GLTs) could alleviate anxiety- and depression-like behaviors in male and female mice by mitigating inflammation. GLTs treatment reversed the effects of maternal separation on inflammatory markers and microglia activation, without adverse effects on immune organ indices, liver, and renal function.