OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc

The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

(2017) Zenggang Li et al.   Nature Communications

Myc and its interactors take shape

(2015) William B. Tu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Anti-proliferative effects of γ-tocotrienol are associated with suppression of c-Myc expression in mammary tumour cells

(2015) P. Parajuli et al.   CELL PROLIFERATION

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

(2015) Kwan-Young Jung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and dynamics of the MKK7–JNK signaling complex

(2015) Jaka Kragelj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications

(2015) S Baldari et al.   Cell Death & Disease

Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

(2015) Özgün Babur et al.   GENOME BIOLOGY

Regulation of c-Myc protein stability by proteasome activator REGγ

(2014) S Li et al.   CELL DEATH AND DIFFERENTIATION

USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer

(2014) J Pan et al.   ONCOGENE

Bimolecular fluorescence complementation (BiFC): A 5-year update and future perspectives

(2012) Yutaka Kodama et al.   BIOTECHNIQUES

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

(2012) P. Chymkowitch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Subcellular Localization of c-Myc Protein Identifies Aggressive B-cell Lymphomas Harboring a c-MYC Translocation

(2010) Marianna B. Ruzinova et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Towards patient-based cancer therapeutics

(2010) Stuart L Schreiber et al.   NATURE BIOTECHNOLOGY