Article
Oncology
Xin Ge, Mengdie Li, Guo-Xin Song, Zhixiang Zhang, Jianxing Yin, Zehe Ge, Zhumei Shi, Ling-Zhi Liu, Bing-Hua Jiang, Xu Qian, Hua Shen
Summary: This study reveals the crucial role of ALDH1A1 in Cr(VI)-induced lung squamous cell carcinoma (LUSC), in which it promotes tumor growth and self-renewal of tumor-initiating cells (TICs) through increased secretion of EGF.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Jinrong Liao, Zeng Chen, Xingguan Luo, Ying Su, Tao Huang, Haipeng Xu, Keyu Lin, Qianlan Zheng, Lurong Zhang, Gen Lin, Xiandong Lin
Summary: This study discovered that hsa_circ_0006692 is overexpressed in non-small-cell lung cancer (NSCLC) and is associated with TNM staging, tumor size, and invasion. Hsa_circ_0006692 promotes NSCLC progression by sponging mir-205-5p and targeting the oncogene CDK19, thereby enhancing cell growth, invasion, migration, and epithelial-mesenchymal transition (EMT) of lung cancer cells. The circ-0006692/mir-205-5p/CDK19 axis may serve as a prognostic biomarker and a potential therapeutic target in NSCLC.
Article
Multidisciplinary Sciences
Ning Li, Huifen Zhou, Van K. Holden, Janaki Deepak, Pushpa Dhilipkannah, Nevins W. Todd, Sanford A. Stass, Feng Jiang
Summary: Streptococcus pneumoniae (SP) attaches to lung cancer cells by binding pneumococcal surface protein C (PspC) to platelet-activating factor receptor (PAFR), stimulating cell proliferation and activating PI3K/AKT and nuclear factor κB (NF-κB) signaling pathways, leading to a pro-inflammatory response. Lung cancer cells infected with SP form larger tumors in mice, and mice treated with both tobacco carcinogen and SP develop more lung tumors and have a shorter survival period. Mutating PspC or PAFR eliminates the tumor-promoting effects of SP. SP overabundance is associated with survival. SP may drive lung tumorigenesis by activating PI3K/AKT and NF-κB pathways through PspC-PAFR binding, providing a microbial target for the diagnosis and treatment of the disease.
Article
Cell Biology
Shimiao Zhu, Zhao Yang, Zheng Zhang, Hongli Zhang, Songyang Li, Tao Wu, Xuanrong Chen, Jianing Guo, Aixiang Wang, Hao Tian, Jianpeng Yu, Changwen Zhang, Lei Su, Zhiqun Shang, Changyi Quan, Yuanjie Niu
Summary: Resistance to antiandrogen is lethal for castration-resistant prostate cancer (CRPC). In this study, we identified HOXB3 as an independent risk factor for progression and death in metastatic CRPC. We demonstrated that HOXB3 activation was associated with WNT pathway genes expression, and suppression of HOXB3 sensitized CRPC to abiraterone treatment. Our findings suggest that targeting HOXB3 may benefit a subgroup of CRPC resistant to antiandrogen therapy.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Zhongyuan Wang, Liang Zhou, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu
Summary: The study identified the significance of the CK1 delta/epsilon-AES axis in colorectal cancer tumorigenesis and metastasis, suggesting that targeted inhibition of this axis could be a potential therapeutic strategy for CRC treatment.
Article
Biochemistry & Molecular Biology
Gongwei Wu, Caixia Suo, Ying Yang, Shengqi Shen, Linchong Sun, Shi-Ting Li, Yingli Zhou, Dongdong Yang, Yan Wang, Yongping Cai, Nana Wang, Huafeng Zhang, Yun-Gui Yang, Jie Cao, Ping Gao
Summary: The oncogene MYC promotes cancer progression by down-regulating N6-methyladenosine (m(6)A) modification preferentially in transcripts of MYC-repressed genes (MRGs). This alteration leads to the activation of ALKBH5 expression and reduction of m(6)A levels in specific MRGs, controlling their translation through the m(6)A reader YTHDF3. Ultimately, inhibiting ALKBH5 or overexpressing SPI1 or PHF12 effectively suppresses the growth of MYC-deregulated B-cell lymphomas.
Article
Genetics & Heredity
Wang Sheng, Weixi Guo, Fang Lu, Hongming Liu, Rongmu Xia, Feng Dong
Summary: Lung cancer is a malignant tumor with high incidence and mortality rates globally. Linc00284, a long non-coding RNA, is significantly upregulated in LC tissues and promotes cancer progression by regulating the miR-205-3p/c-Met axis.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Cell Biology
Li Ding, Yinan Feng, Longguang Li
Summary: This study elucidates the role of circular RNA 0001955 (circ_0001955) in the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and its underlying mechanism. The results demonstrate that circ_0001955 is up-regulated in NSCLC tissues and cells, and its overexpression is associated with advanced tumor stage and lymph node metastasis. Overexpression of circ_0001955 enhances cell proliferation and inhibits apoptosis in NSCLC cells, while knockdown of circ_0001955 has the opposite effects. Circ_0001955 directly targets miR-769-5p and negatively regulates its expression. Furthermore, EGFR, a target gene of miR-769-5p, can be indirectly and positively regulated by circ_0001955. Correlation analysis reveals a negative correlation between circ_0001955 and miR-769-5p expression, while circ_0001955 is positively correlated with EGFR expression. Circ_0001955 promotes NSCLC cell proliferation and inhibits apoptosis by modulating the miR-769-5p/EGFR axis.
Article
Biochemistry & Molecular Biology
Chao Li, Shang-Ze Li, Xi-Cheng Huang, Jie Chen, Wenbin Liu, Xiao-Dong Zhang, Xue-Min Song, Run-Lei Du
Summary: PTPN18 is overexpressed in colorectal cancer, promoting cell growth and tumorigenesis; deficiency of PTPN18 inhibits tumorigenesis; PTPN18 activates the MYC signaling pathway and enhances CDK4 expression.
Article
Genetics & Heredity
Tiezhi Li, Na Wang, Shujun Li, Hongjiang Yan, Shaolin Gao, Weinian Gao, Ruoxuan Xu
Summary: Previous studies have reported the involvement of ANP32B in various cancers, but its role in lung cancer was unknown. This study found elevated levels of ANP32B in lung cancer tissues and cells. Knockdown of ANP32B inhibited lung cancer cell proliferation and migration, while overexpression of ANP32B promoted malignant progression. ANP32B was also found to regulate apoptosis and cell cycling in lung cancer cells. Additionally, VDAC1 was identified as a downstream target of ANP32B in lung cancer cells, and its expression was positively associated with ANP32B expression in lung adenocarcinoma samples.
Article
Biochemistry & Molecular Biology
Xiaohong Xia, Tumei Hu, Xiaoyue He, Yuan Liu, Cuifu Yu, Weiyao Kong, Yuning Liao, Daolin Tang, Jinbao Liu, Hongbiao Huang
Summary: This study reveals that neddylation of HER2 is a novel post-translational modification that regulates its expression and oncogenic activity in human breast cancer. The inhibition of neddylation synergizes with trastuzumab to suppress the growth of HER2 positive breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Dipti Kanabar, Mimansa Goyal, Emma Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, Aaron Muth
Summary: This study reports the structure-based design of small molecules that can bind to Gankyrin and inhibit its overexpression in breast and lung cancers, showing potential therapeutic value.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaohong Xia, Tumei Hu, Xiaoyue He, Yuan Liu, Cuifu Yu, Weiyao Kong, Yuning Liao, Daolin Tang, Jinbao Liu, Hongbiao Huang
Summary: This study reveals that neddylation of HER2 controls its expression and oncogenic activity in human breast cancer. NEDD8 and NAE1, critical components in the neddylation pathway, are found to be positively correlated with HER2 expression. HER2 interacts directly with NEDD8 and NAE1, and neddylation inhibition leads to decreased HER2 protein expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Zhefeng Lou, Weiwei Lin, Huirong Zhao, Xueli Jiao, Cong Wang, He Zhao, Lu Liu, Yu Liu, Qipeng Xie, Xing Huang, Haishan Huang, Lingling Zhao
Summary: The study found that ALPL is downregulated in LUAD, and low ALPL expression is significantly associated with reduced disease-free survival rate in patients. Further research showed that overexpression of ALPL in LUAD cell lines did not significantly affect cell proliferation, but significantly attenuated lung metastasis in a mouse model. ALPL downregulation in LUAD led to a decrease in phosphorylated (p)-ERK, resulting in the accumulation of c-Myc and increased RhoA transcription, enhancing LUAD cell metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
I-Ying Kuo, Danping Liu, Wu-Wei Lai, Yi-Ching Wang, Y. Peng Loh
Summary: This study evaluates the efficacy of CPE/CPE-Delta N mRNA as a biomarker for predicting recurrence in lung adenocarcinoma patients. The results show that CPE/CPE-Delta N copy number is associated with recurrence and death, and it performs better in predicting recurrence in stage I and II patients.
Article
Medicine, Research & Experimental
Pei-Shan Yang, Min-Hua Yu, Ya-Chin Hou, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan, Yi-Ching Wang
Summary: This study provides the first evidence that Rab37 mediates CHI3L1 secretion in immune cells and highlights the dual properties of CHI3L1 nAbs that can target both cancer cells and the tumor microenvironment.
Article
Oncology
Hsueh-Chien Chiang, Meng-Ying Lin, Forn-Chia Lin, Nai-Jung Chiang, Yi-Ching Wang, Wu-Wei Lai, Wei-Lun Chang, Bor-Shyang Sheu
Summary: This study aimed to compare the sensitivity of serum prealbumin, transferrin, and albumin in detecting malnutrition and predicting survival in esophageal cancer patients. The results showed that prealbumin and transferrin outperformed albumin in identifying malnutrition and poor prognosis.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Yung-Ching Chen, Ming-Jer Young, Hui-Ping Chang, Chia-Yu Liu, Chia-Chi Lee, Yau-Lin Tseng, Yi-Ching Wang, Wen-Chang Chang, Jan-Jong Hung
Summary: This study reveals that estrogen negatively regulates DNMT1 and p53 expression in female lung cancer, which not only affects tumor cells but also modulates the tumor microenvironment, leading to a poor prognosis.
Review
Medicine, Research & Experimental
Chih-Hsiung Hsieh, Yi-Ching Wang
Summary: The protein gelsolin plays a significant role in controlling cytoskeletal remodeling, cell morphology, differentiation, movement, and apoptosis. Its expression has been found to be decreased in various pathological conditions and it has emerged as a potential diagnostic biomarker for early disease detection. Gelsolin can function as either an oncoprotein or a tumor suppressor depending on the type of carcinoma. This review discusses the roles of gelsolin in inflammation and wound healing, cancers, and tumor microenvironment, as well as future prospects for related studies and clinical application.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Yi-Zih Kuo, Ya-Rong Kang, Wei-Lun Chang, Lydia Chin-Ling Sim, Tzu-Chin Hsieh, Chu-Han Chang, Yi-Ching Wang, Ching-Jung Tsai, Li-Chun Huang, Sen-Tien Tsai, Li-Wha Wu
Summary: YAP1 acts as a tumor suppressor in esophageal cancer, while TAZ plays a pro-tumor role. YAP1 negatively regulates the expression of TAZ through transcriptional and translational control.
Article
Cell Biology
Shan-Ying Wu, Hung-Tsung Wu, Yi-Ching Wang, Chih-Jen Chang, Yan-Shen Shan, Shang-Rung Wu, Yen-Chi Chiu, Chia-Lang Hsu, Hsueh-Fen Juan, Kai-Ying Lan, Chi-Wen Chu, Ying-Ray Lee, Sheng-Hui Lan, Hsiao-Sheng Liu
Summary: This study reveals that secretory autophagy promotes RAB37-mediated insulin secretion to maintain the homeostasis of insulin and glucose.
Editorial Material
Cell Biology
Shan-Ying Wu, Yi-Ching Wang, Roberto Zuchini, Kai-Ying Lan, Hsiao-Sheng Liu, Sheng-Hui Lan
Summary: RAB37 GTPase regulates cargo exocytosis by cycling between GDP-bound and GTP-bound forms. It also simultaneously regulates autophagy activation and TIMP1 secretion in lung cancer cells under starvation conditions. Secretory autophagy participates in TIMP1 secretion in a RAB37- and Sec22b-dependent manner. Autophagy induction facilitates TIMP1 secretion and suppresses the motility and metastasis of lung cancer cells in a RAB37-dependent manner in a lung-to-lung mouse model.
Article
Chemistry, Multidisciplinary
Chun-Hua Hsu
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerging infectious pathogen that causes coronavirus disease 2019 (COVID-19). The virus infects cells primarily through its spike glycoprotein, which undergoes cleavage into S1 and S2 subunits to facilitate cell attachment and membrane fusion, respectively. The fusion core of SARS-CoV-2, consisting of heptad repeat 1 (HR1) and heptad repeat 2 (HR2), forms a stable trimeric complex with a six-helix bundle structure. The crystal structure of the fusion core reveals the antiparallel arrangement of three HR1 coiled-coils surrounded by HR2. These findings suggest that the SARS-CoV-2 fusion core shares similarities with other class I viral glycoproteins and may be targeted for drug repurposing to combat COVID-19.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Medicine, Research & Experimental
Chiao-Hui Hsieh, Chen-Tsung Huang, Yi-Sheng Cheng, Chun-Hua Hsu, Wen-Ming Hsu, Yun-Hsien Chung, Yen-Lin Liu, Tsai-Shan Yang, Chia-Yu Chien, Yu-Hsuan Lee, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: Homoharringtonine has been identified as an efficient treatment for neuroblastoma by inhibiting PHGDH activity, leading to intricate alterations in cellular metabolism and oxidative stress, resulting in effective tumor reduction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Sheng-Chia Chen, Bo-Chen Jiang, Yen-Ju Lu, Chia-Hao Chang, Tsung-Han Wu, Sheng-Wei Lin, Hua-Wen Yin, Tzong-Huei Lee, Chun-Hua Hsu
Summary: Antrodia cinnamomea is a medicinal plant found only in Taiwan, with various health benefits such as treating inflammation, diarrhea, and abdominal pain. It contains terpenoids that have multiple bioactivities, making them potential food additives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Shaifali Singh, Nai Yang Yeat, Ya-Ting Wang, Shu-Yu Lin, I-Ying Kuo, Kuen-Phon Wu, Won-Jing Wang, Wen-Ching Wang, Wu-Chou Su, Yi-Ching Wang, Ruey-Hwa Chen
Summary: WDR4/PTPN23 axis plays a central role in the trafficking of EGFR and c-MET in non-small cell lung cancer (NSCLC). WDR4-mediated PTPN23 ubiquitination inhibits lysosome trafficking and degradation, sustaining EGFR and c-MET signaling and promoting NSCLC proliferation, migration, and metastasis. Clinical studies show that low expression of PTPN23 is associated with high expression of WDR4 and poor prognosis in lung cancer. Targeting WDR4-mediated PTPN23 ubiquitination may be a potential therapeutic strategy for EGFR TKI-resistant NSCLC.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Athika Darumas Putri, Ming-Jen Hsu, Chia-Li Han, Fang-Ching Chao, Chun-Hua Hsu, Christian D. Lorenz, Chien-Ming Hsieh
Summary: This study evaluated the protein corona formation on albumin nanoparticles (NPs) and liposomes through in vitro and simulation studies. The results showed that serum concentration and the presence of a hard protein corona influenced the cellular uptake efficiency of the NPs.
Review
Cell Biology
I. -Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang, Yi-Ching Wang
Summary: Cells in the tumor microenvironment require a class of checkpoints to regulate various secretion and transport processes. Recent studies have shown that Rab proteins mediate communication between diverse cargoes and substrates through vesicular trafficking and secretion pathways in the tumor microenvironment. This review focuses on the role and regulation of vesicular secretion pathways in the tumor microenvironment, and describes the latest research advances and future directions.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Ming-Jer Young, Yung-Ching Chen, Shao-An Wang, Hui-Ping Chang, Wen-Bin Yang, Chia-Chi Lee, Chia-Yu Liu, Yau-Lin Tseng, Yi-Ching Wang, H. Sunny Sun, Wen-Chang Chang, Jan-Jong Hung
Summary: Decreased Sp1 levels in lung cancer are associated with poor prognosis and are related to estrogen. It has been found that E2 can decrease Sp1 levels by increasing the expression of RNF4, and ultimately lead to malignancy in lung cancer.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
