Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applications

Early and multiple origins of metastatic lineages within primary tumors

(2016) Zi-Ming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of LATS kinases alters p53 to promote cell migration

(2015) Noa Furth et al.   GENES & DEVELOPMENT

Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets

(2015) David Amar et al.   NUCLEIC ACIDS RESEARCH

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

(2015) Jing Guo et al.   NUCLEIC ACIDS RESEARCH

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types

(2015) Jiarui Ding et al.   Nature Communications

Evaluation and integration of cancer gene classifiers: identification and ranking of plausible drivers

(2015) Yang Liu et al.   Scientific Reports

Improving decision making about clinical trial participation – a randomised controlled trial of a decision aid for women considering participation in the IBIS-II breast cancer prevention trial

(2014) I Juraskova et al.   BRITISH JOURNAL OF CANCER

Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality

(2014) Livnat Jerby-Arnon et al.   CELL

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Constructing module maps for integrated analysis of heterogeneous biological networks

(2014) David Amar et al.   NUCLEIC ACIDS RESEARCH

Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer

(2014) Hideya Onishi   WORLD JOURNAL OF GASTROENTEROLOGY

Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine

(2014) Benjamin J Raphael et al.   Genome Medicine

Ontology-aware classification of tissue and cell-type signals in gene expression profiles across platforms and technologies

(2013) Young-suk Lee et al.   BIOINFORMATICS

A Review on Multi-Label Learning Algorithms

(2013) Min-Ling Zhang et al.   IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Computational approaches to identify functional genetic variants in cancer genomes

(2013)   NATURE METHODS

Network-based stratification of tumor mutations

(2013) Matan Hofree et al.   NATURE METHODS

MuSiC: Identifying mutational significance in cancer genomes

(2012) N. D. Dees et al.   GENOME RESEARCH

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data

(2011) A. Lan et al.   NUCLEIC ACIDS RESEARCH

Disease Ontology: a backbone for disease semantic integration

(2011) L. M. Schriml et al.   NUCLEIC ACIDS RESEARCH

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

(2010) J. Montojo et al.   BIOINFORMATICS

Hedgehog signaling and therapeutics in pancreatic cancer

(2010) F. C. Kelleher   CARCINOGENESIS

LATS tumor suppressor: A new governor of cellular homeostasis

(2010) Stacy Visser et al.   CELL CYCLE

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL