Journal
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 74, Issue 11, Pages 802-809Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/oemed-2016-104080
Keywords
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Funding
- Government of Canada Banting Post doctoral Fellowship
- National Institutes for Health (NIH) [1R01CA124759]
- AFSSET [ST-2005-004]
- European Fifth Framework Program [100 QLK4-CT-1999901563]
- International Union against Cancer (UICC)
- Mobile Manufacturers' Forum
- GSM Association
- Australian National Health and Medical Research Council (EME) [219129]
- University of Sydney Medical Foundation Program
- Cancer Council NSW
- Cancer Council Victoria
- Canadian Institutes of Health Research [MOP-42525]
- Canada Research Chair programme
- Guzzo-CRS Chair in Environment and Cancer
- Fonds de larecherche en sante du Quebec
- Canadian Institutes of Health Research(CIHR)
- Canadian Wireless Telecommunications Association
- NSERC Chair in Risk Science at the University of Ottawa
- German Federal Ministry for the Environment, Nuclear Safety, and Nature Protection
- Ministry for the Environment and Traffic of the state of Baden-Wurttemberg
- Ministry for the Environment of the state of North Rhine-Westphalia
- MAIFOR Program (Mainzer Forschungsforderungsprogramm) of University of Mainz
- Health Research Council
- Hawkes Bay Medical Research Foundation
- Wellington Medical Research Foundation
- Waikato Medical Research Foundation
- Cancer Society of New Zealand
- Mobile Telecommunications, Health andResearch (MTHR) programme
- Health and Safety Executive
- Department of Health
- UK Network Operator (O2)
- UK Network Operator (Orange)
- UK Network Operator (T-Mobile)
- UK Network Operator (Vodafone)
- UK Network Operator ('3')
- Scottish Executive
- [N85142]
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Objectives In absence of clear evidence regarding possible effects of occupational chemical exposures on brain tumour aetiology, it is worthwhile to explore the hypothesis that such exposures might act on brain tumour risk in interaction with occupational exposure to extremely low frequency magnetic fields (ELF). Methods INTER OCC is a seven-country (Australia, Canada, France, Germany, Israel, New Zealand and UK), population-based, case-control study, based on the larger INTERPHONE study. Incident cases of primary glioma and meningioma were ascertained from 2000 to 2004. Job titles were coded into standard international occupational classifications and estimates of ELF and chemical exposures were assigned based on job-exposure matrices. Dichotomous indicators of cumulative ELF (>= 50th vs <50th percentile, 1-4 year exposure time window) and chemical exposures (ever vs never, 5-year lag) were created. Interaction was assessed on both the additive and multiplicative scales. Results A total of 1939 glioma cases, 1822 meningioma cases and 5404 controls were included in the analysis, using conditional logistic regression. There was no clear evidence for interactions between ELF and any of the chemical exposures assessed for either glioma or meningioma risk. For glioma, subjects in the low ELF/metal exposed group had a lower risk than would be predicted from marginal effects. Results were similar according to different exposure time windows, to cut-points of exposure or in exposed-only analyses. Conclusions There was no clear evidence for interactions between occupational ELF and chemical exposures in relation to glioma or meningioma risk observed. Further research with more refined estimates of occupational exposures is recommended.
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