Journal
OBESITY REVIEWS
Volume 18, Issue 11, Pages 1260-1271Publisher
WILEY
DOI: 10.1111/obr.12590
Keywords
Gut microbiota; intervention; obesity; precision medicine
Categories
Funding
- National Natural Science Foundation of China [31471718]
- National Key Technology RD Program [2015BAD16B02]
- Modern Agricultural Industry Technology System [CARS-30]
- National Natural Science Foundation of China [31471718]
- National Key Technology RD Program [2015BAD16B02]
- Modern Agricultural Industry Technology System [CARS-30]
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Obesity is one of the most serious global public health challenges of the 21st century. The adjustment of gut microbiota is often recommended as an efficient strategy to treat obesity. This modulation of gut microbiota can be performed by many methods, including dietary intervention, antibiotic application, the use of prebiotics and probiotics, bariatric surgery and faecal microbiota transplantation. In most cases, positive effects have been observed in response to treatment, but invalid and even contrary effects have also been observed in some cases due to factors that are unrelated to intervention methods, such as genetic factors, patient age or gender, environmental microbiota, climate, geography and lifestyle. These factors can cause variation of gut microbial populations and thus should also be taken into consideration when selecting modulation strategies.
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