Journal
OBESITY RESEARCH & CLINICAL PRACTICE
Volume 11, Issue 4, Pages 464-474Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.orcp.2016.10.287
Keywords
MicroRNAs; Epienetics; Pre-pregnancy obesity; Pregnancy
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Funding
- March of Dimes [1 FY08-425]
- National Institutes of Health [R01HD032562, R01HD034543, K01HL103174, K08DK103945]
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Background: Maternal pre-pregnancy overweight and obese status has been associated with a number of pregnancy complications and adverse offspring outcomes. Mechanisms for observed associations, however, are largely unknown. We investigated associations of pre-pregnancy body mass index with early-mid pregnancy epigenetic biomarkers, circulating microRNAs. Methods: Peripheral blood was collected from participants (16-27 weeks gestation) of two multi-racial pregnancy cohorts, the Omega Study and the Pregnancy Outcomes and Community Health Study. Plasma miRNA expression was characterised using epigenome-wide (319 miRNAs) profiling among 20 pregnant women in each cohort. Cohort-specific linear regression models that included the predictor (pre-pregnancy body mass index), the outcome (microRNA expression), and adjustment factors (maternal age, gestational age at blood collection, and race) were fit. Results: Expression of 27 miRNAs was positively associated with pre-pregnancy body mass index in both cohorts (p-values <0.05). A number of these differentially expressed miRNAs have previously been associated with adipogenesis (e.g. let-7d*, miR-103-2*,-130b,-146b-5-p,-29c, and -26b). Identified miRNAs as well as their experimentally validated targets participate in pathways that involve organismal injury, reproductive system disease, connective tissue disorders, cancer, cellular development, growth and proliferation. Conclusion: Pre-pregnancy body mass index is associated with circulating miRNAs in early-mid pregnancy. Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.
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