Article
Endocrinology & Metabolism
Silvia Patricia Alonso, Sergio Valdes, Cristina Maldonado-Araque, Ana Lago, Pilar Ocon, Alfonso Calle, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Juan Girbes, Felipe Chaves, Sara Garcia-Serrano, Eva Garcia-Escobar, Jose Carlos Fernandez-Garcia, Gabriel Olveira, Natalia Colomo, Gemma Rojo-Martinez
Summary: The study found that the thyroid hormone resistance index is associated with the risk of all-cause mortality in the adult population of Spain.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Rodrigo Ayala-Yanez, Andres Villapando-Basaldua, Alejandra Halffter-Mijares, Dan Morgenstern-Kaplan, Ixel Lorena Ruiz-Cabrera, Guadalupe Herrera-Fernandez
Summary: This study aimed to evaluate the role of thyroid function in fetal development and neonatal growth, and to determine accurate diagnostic levels for thyroid deficiency through quantification of TSH and FT4 levels. The results showed that using the ATA 2017 values decreased the population of gestational hypothyroidism patients, preventing overdiagnosis and overtreatment. No significant complications were associated, highlighting the need for regional-specific values and education on early prenatal consultation and thyroid function testing.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xueqi Zhang, Yang Li, Jing Jin, Huangman Wang, Bozun Zhao, Songwen Wang, Zhongyan Shan, Weiping Teng, Xiaochun Teng
Summary: Subclinical hypothyroidism (SCH) is a common endocrine disorder characterized by elevated TSH levels and normal FT4 levels. This study aims to prospectively observe elderly patients with SCH, screened using both age-specific and non-age-specific TSH reference ranges, in order to reduce overdiagnosis and overtreatment of elderly patients with SCH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biodiversity Conservation
Simona Bonelli, Francesca Barbero, Arianna Zampollo, Cristiana Cerrato, Piero Genovesi, Valentina La Morgia
Summary: This study proposes a mixed reference/model-based approach to set the Favourable Reference Population (FRP) and Range (FRR) for a threatened butterfly, Parnassius apollo, in the Italian Alps. The method uses a habitat suitability map and a clumping procedure to identify suitable habitat patches, providing a basis for defining FRVs.
ECOLOGICAL INDICATORS
(2021)
Article
Endocrinology & Metabolism
Simone Canovi, Silvia Vezzani, Alessandra Polese, Andrea Frasoldati, Clara Schiatti, Cristina Preda, Michele Corradini Zini, Antonio Vitiello, Marco Foracchia, Giuseppina Comitini, Lorenzo Aguzzoli, Tommaso Fasano, Luigi Vecchia
Summary: This study established pregnancy-related reference intervals for serum TSH in singleton pregnant women using real-life clinical data, which may reduce the risk of misclassification in pregnant women undergoing thyroid function testing.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Ulrike Dapp, Dominic Vinyard, Stefan Golgert, Sebastian Krumpoch, Ellen Freiberger
Summary: This study used a new method to evaluate gait characteristics of older adults and stratified gait parameters based on functional ability. The results showed that functional level stratification revealed a wide range of functional decline for all gait parameters, and had greater differentiation than age stratification.
Article
Biochemistry & Molecular Biology
Huijia Lin, Mudan Ye, Zhenwen Zhou, Lianxiong Yuan, Gendie E. Lash, Guanglan Zhang, Li Li
Summary: This study established reference ranges for thyroid hormones in early pregnancy in China and found that higher BMI, higher maternal parity, and older maternal age may increase the risk of thyroid dysfunction.
BIOSCIENCE REPORTS
(2021)
Review
Medical Laboratory Technology
Onyebuchi E. Okosieme, Medha Agrawal, Danyal Usman, Carol Evans
Summary: The reference intervals for gestational TSH and FT4 differ according to assay methods, with significant variations observed across different studies. Laboratories should derive method-specific gestation reference intervals instead of extrapolating from non-pregnant values.
ANNALS OF CLINICAL BIOCHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Lale Susan Karakis, Huseyin Kiyak, Berfin Okmen, Cagdas Ozdemir, Engin Turkgeldi
Summary: This study aimed to investigate the impact of subclinical hypothyroidism on fertility. The results showed that in women with unexplained infertility, serum TSH levels between 2.5 and 4.5 mIU/L were not associated with lower pregnancy rates compared to TSH levels between 0.3 and 2.5 mIU/L.
Article
Endocrinology & Metabolism
Geoffrey Omuse, David Kawalya, Patrick Mugaine, Assumpta Chege, Daniel Maina
Summary: This study determined reference intervals (RIs) for thyroid stimulating hormone (TSH) and free thyroxine (FT4) in neonates using data from a hospital in Kenya. The RIs obtained were different from those provided by Siemens. These RIs will serve as a guide for interpreting thyroid function tests in neonates from sub-Saharan Africa where screening for congenital hypothyroidism is done using the Siemens Atellica (R) IM analyzer.
BMC ENDOCRINE DISORDERS
(2023)
Article
Obstetrics & Gynecology
Bharti Goel, Poonam Goel, Jasbinder Kaur
Summary: Recent evidence suggests that TSH levels are population specific due to differences in ethnicity, leading to the recommendation of tailoring treatment based on local reference ranges. In a study of 604 pregnant women, a TSH upper limit of 4.5 mIU/L during pregnancy was suggested for low-risk North Indian women, with a median urinary iodine level of 255 μg/L.
JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA
(2021)
Article
Endocrinology & Metabolism
Philipp Fervers, Florian Fervers, Miriam Rinneburger, Mathilda Weisthoff, Jonathan Kottlors, Robert Reimer, David Zopfs, Erkan Celik, David Maintz, Nils Grosse-Hokamp, Thorsten Persigehl
Summary: The purpose of this study was to investigate the physiological range of bone marrow iodine uptake after intravenous contrast application and examine its dependence on vBMD, iodine blood pool, patient age, and sex. A retrospective analysis was performed on oncological patients without evidence of metastatic disease. The results showed that vBMD and portal vein iodine blood pool had the strongest impact on bone marrow iodine uptake, and adjusted reference values were calculated based on these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Demewoz Haile, Kenneth H. Brown, Christine M. McDonald, Hanqi Luo, Michael Jarvis, Ismael Teta, Alex Ndjebayi, Guintang Assiene Jules Martial, Stephen A. Vosti, Reina Engle-Stone
Summary: The nutrient reference values (NRVs) for zinc set by different authorities differ widely and can affect the predicted prevalence of inadequate zinc intake. A study in Cameroon found substantial variations in the prevalence of inadequate intake among children and women, depending on the NRVs applied. These differences have significant implications for the benefit and cost-effectiveness of zinc fortification programs. Efforts should be made to harmonize the NRVs for zinc.
Article
Endocrinology & Metabolism
Kazuhiro Shimura, Kento Ikegawa, Yukihiro Hasegawa
Summary: This study aimed to compare the basal and peak TSH values in long-term follow-up patients with CH during TRH-T and found that basal TSH levels alone may predict the long-term therapeutic prognosis of CH patients.
CLINICAL PEDIATRIC ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Juan J. Diez, Pedro Iglesias
Summary: Inadequate control of thyroid dysfunction is a common and harmful health problem. A study in Spain found that 46.02% of patients receiving treatment for hyperthyroidism had TSH values outside the reference range, indicating inappropriate treatment. This highlights the need for clinicians and health authorities to address this public health issue.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Suping Ling, Francesco Zaccardi, Bogdan Vlacho, Ping Li, Jordi Real Gatius, Manel Mata-Cases, Josep Franch-Nadal, Mikhail N. Kosiborod, Clare Gillies, Peter Fenici, Didac Mauricio, Baiju R. Shah, Kamlesh Khunti
Summary: This study aimed to understand the geographical and temporal patterns in the excess mortality risk associated with type 2 diabetes (T2D) in three high-income countries. The results showed similar diabetes gaps between Ontario and England, particularly in elderly subjects, while Catalonia had lower mortality rates in men with T2D from the age of 60 years.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Fernando Gomez-Peralta, Cristina Abreu, Elsa Fern Andez-Rubio, Laura Cotovad, Pedro Pujante, Sonia Gaztambide, Diego Bellido, Edelmiro Menendez Torre, Santiago Ruiz-Valdepenas, Hugo Bello, Xoan Valledor, Jesus Erez-Gonzalez, Luis Ruiz-Valdepenas
Summary: This study aimed to assess the efficacy of the insulin pen cap Insulclock in improving glycemic control, treatment adherence, and user satisfaction in people with type 1 diabetes. The results showed that the use of the Insulclock system was associated with improved glycemic control, reduced glycemic variability and hyperglycemia risk, as well as increased treatment adherence.
Article
Endocrinology & Metabolism
Angels Mollo, Bogdan Vlacho, Monica Gratacos, Manel Mata-Cases, Esther Rubinat, Anna Berenguera, Jordi Real, Ramon Puig-Treserra, Xavier Cos, Josep Franch-Nadal, Kamlesh Khunti, Didac Mauricio, INTEGRA Res grp
Summary: A specially designed multicomponent healthcare intervention can improve glycaemic control in subjects with poorly controlled type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mitsuhide Naruse, Masanori Murakami, Takuyuki Katabami, Tomaz Kocjan, Mirko Parasiliti-Caprino, Marcus Quinkler, Matthieu St-Jean, Sam O'Toole, Filippo Ceccato, Ivana Kraljevic, Darko Kastelan, Mika Tsuiki, Jaap Deinum, Edelmiro Menendez Torre, Troy Puar, Athina Markou, George Piaditis, Kate Laycock, Norio Wada, Marianne Aardal Grytaas, Hiroki Kobayashi, Akiyo Tanabe, Chin Voon Tong, Nuria Valdes Gallego, Sven Gruber, Felix Beuschlein, Lydia Kuerzinger, Norlela Sukor, Elena A. B. Aisha Azizan, Oskar Ragnarsson, Michiel F. Nijhoff, Giuseppe Maiolino, Guido Di Dalmazi, Valentina Kalugina, Andre Lacroix, Raluca Maria Furnica, Tomoko Suzuki
Summary: This study investigated the diversity of approaches utilized for each diagnostic step in different expert centers regarding primary aldosteronism (PA). The results showed significant variations in blood sampling conditions, assay methods, screening and confirmatory tests among centers. This diversity may lead to inconsistent diagnosis of PA and limit comparison of evidence between centers. Standardization of the diagnostic process and revisiting the concept of mild PA are necessary.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jessica Ares Blanco, Carmen Lambert, Manuel Fernandez-Sanjurjo, Paula Morales-Sanchez, Pedro Pujante, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Edelmiro Menendez Torre, Elias Delgado
Summary: The aim of this study was to investigate the glucose tolerance status after 15 years of pregnancy in women diagnosed with gestational diabetes mellitus (GDM) and to assess the long-term effect of GDM on circulating miRNA profile. The study included 30 randomly selected women diagnosed with GDM during 2005-2006, and glucose tolerance was measured using the National Diabetes Data Group criteria. Four miRNAs were analyzed in the plasma of women 15 years after the diagnosis of GDM. The study found that 50% of women had some degree of glucose intolerance 15 years after the diagnosis of GDM, which was directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed significantly increased levels of circulating hsa-miR-24-3p. Thus, initial weight and BMI, along with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Oscar Osorio-Conles, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
Summary: Hypertriglyceridemia is associated with increased risk of pancreatitis and cardiovascular disease. Fibrosis of subcutaneous adipose tissue is related to changes in triglyceride levels. FABP4 gene may be a potential drug target for the treatment of hypertriglyceridemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Endocrinology & Metabolism
F. Gomez-Peralta, E. Menendez, S. Conde, I. Conget, A. Novials
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Betina Biagetti, Pedro Iglesias, Rocio Villar-Taibo, Maria-Dolores Moure, Miguel Paja, Marta Araujo-Castro, Jessica Ares, Cristina Alvarez-Escola, Almudena Vicente, Elia Alvarez Guivernau, Iria Novoa-Testa, Fernando Guerrero Perez, Rosa Camara, Beatriz Lecumberri, Carlos Garcia Gomez, Ignacio Bernabeu, Laura Manjon, Sonia Gaztambide, Fernando Cordido, Susan M. Webb, Edelmiro Luis Menendez-Torre, Juan J. Diez, Rafael Simo, Manel Puig-Domingo
Summary: This study compared the clinical characteristics, comorbidities, treatment approaches, and mortality rate of patients diagnosed with acromegaly before or after 2010 and compared the overall mortality rate with the general Spanish population. The results showed no significant difference in mortality rate among acromegaly patients diagnosed at age 65 or older, and no significant difference compared to the general population in Spain.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Raul Rodriguez Escobedo, Carmen Lambert, Paula Morales Sanchez, Elias Delgado Alvarez, Edelmiro Menendez Torre
Summary: The study aimed to determine the frequency of reclassification from T2D to T1D, characteristics of patients, and the impact on disease management. It found that misdiagnosis of T1D as T2D is common in adults, and age, BMI, insulin use, and other clinical features are not definitive discriminators between the two. Reclassification of the diagnosis has important implications for metabolic control.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Orthopedics
Magdalena Bundo, Bogdan Vlacho, Judit Llussa, Isabel Bobe, Meritxell Aivar, Carmen Ciria, Ana Martinez-Sanchez, Jordi Real, Manel Mata-Cases, Xavier Cos, Montserrat Doria, Jordi Viade, Josep Franch-Nadal, Didac Mauricio
Summary: This study evaluated the prognosis of diabetic foot ulcer (DFU) in primary care centers in Catalonia, Spain, over a 12-month period. The results showed high mortality, amputation, and recurrence rates, and low healing rate among patients with DFU. Diabetes complications and high PEDIS/SINBAD scores were associated with poor clinical outcomes.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Paula Morales-Sanchez, Carmen Lambert, Jessica Ares-Blanco, Lorena Suarez-Gutierrez, Elsa Villa-Fernandez, Ana Victoria Garcia, Miguel Garcia-Villarino, Juan Ramon Tejedor, Mario F. Fraga, Edelmiro Menendez Torre, Pedro Pujante, Elias Delgado
Summary: This study aimed to analyze the circulating miRNA expression profile of patients with type 1 diabetes and no other associated pathology. The expression of hsa-miR-1-3p was found to be significantly increased in patients with type 1 diabetes and positively correlated with glycated haemoglobin levels. Changes in hsa-miR-1-3p were also found to directly affect genes involved in vascular development and cardiovascular pathologies. Circulating hsa-miR-1-3p, along with glycemic control, could be used as prognostic biomarkers in type 1 diabetes to prevent the development of vascular complications in these patients.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Idalia Rojo-Lopez, Marcelino Bermudez-Lopez, Eva Castro, Cristina Farras, Gerard Torres, Reinald Pamplona, Albert Lecube, Jose Manuel Valdivielso, Elvira Fernandez, Josep Julve, Esmeralda Castelblanco, Josep Franch-Nadal, Nuria Alonso, Minerva Granado-Casas, Didac Mauricio
Summary: The aim of this study was to evaluate the association between the Mediterranean diet and subclinical atherosclerotic disease. The results showed that higher adherence to the Mediterranean diet was associated with a lower risk of atherosclerotic plaques, and moderate or high adherence to the diet was associated with a lower number of plaques.
Article
Endocrinology & Metabolism
Enrique Ozcariz, Montse Guardiola, Nuria Amigo, Gemma Rojo-Martinez, Sergio Valdes, Pere Rehues, Lluis Masana, Josep Ribalta
Summary: The aim of this study was to combine nuclear magnetic resonance-based metabolomics and machine learning to identify a glucose-independent molecular signature associated with future type 2 diabetes development. A metabolomic analysis was performed on serum samples from individuals in the Di@bet.es study, revealing lipoprotein and glycoprotein profiles as well as 15 low molecular weight metabolites that were related to the development of type 2 diabetes. Machine learning models also highlighted the roles of inflammation and muscle as independent factors in the development of type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Sergio Valdes, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Eva Garcia-Escobar, Sara Garcia-Serrano, Wasima Oualla-Bachiri, Marta Garcia-Vivanco, Juan Luis Garrido, Victoria Gil, Fernando Martin-Llorente, Alfonso Calle-Pascual, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbes, F. Javier Chaves, Jose L. Galan-Garcia, Gabriel Aguilera-Venegas, Joan Carles Vallve, Nuria Amigo, Montse Guardiola, Josep Ribalta, Gemma Rojo-Martinez
Summary: The study aimed to assess the associations between exposure to air pollutants and lipoprotein measures in the adult population of Spain. The results showed that exposure to particulate matter and nitrogen dioxide was associated with lower levels of high-density lipoprotein cholesterol and particles, as well as increased risk of low high-density lipoprotein cholesterol and particles. Subgroup analysis further revealed that the effects of particulate matter and nitrogen dioxide were more pronounced in men and individuals with obesity.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
