Article
Nutrition & Dietetics
Felipe Caamano-Navarrete, Daniel Jerez-Mayorga, Cristian Alvarez, Indya del-Cuerpo, Mauricio Cresp-Barria, Pedro Delgado-Floody
Summary: This study aimed to investigate the association between muscle quality index (MQI), metabolic syndrome (MetS) markers, and cardiorespiratory fitness (CRF) in morbidly obese patients. It also examined the potential mediation role of MQI in the relationship between abdominal obesity and systolic blood pressure (SBP). The results showed an inverse association between MQI and MetS markers, as well as a positive association between MQI and CRF. MQI was found to partially mediate the relationship between abdominal obesity and SBP.
Article
Sport Sciences
Eero A. Haapala, Tuomo Tompuri, Niina Lintu, Anna Viitasalo, Kai Savonen, Timo A. Lakka, Jari A. Laukkanen
Summary: Cardiorespiratory fitness is inversely associated with cardiometabolic risk factors, but the association weakens when considering body size and composition. Regardless of the scaling approach, cardiorespiratory fitness is consistently positively associated with high-density lipoprotein cholesterol levels.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Endocrinology & Metabolism
Eero A. Haapala, Marja H. Leppanen, Maarit Lehti, Niina Lintu, Tuomo Tompuri, Anna Viitasalo, Ursula Schwab, Timo A. Lakka
Summary: Cardiorespiratory fitness is associated with a cardioprotective metabolite profile in children, independent of body fat percentage. Associations between fitness and certain serum metabolites remained significant even after adjusting for body fat.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Angela Lehn-Stefan, Andreas Peter, Juergen Machann, Fritz Schick, Elko Randrianarisoa, Martin Heni, Robert Wagner, Andreas L. Birkenfeld, Andreas Fritsche, Matthias B. Schulze, Norbert Stefan, Konstantinos Kantartzis
Summary: For a given body mass index (BMI), both impaired metabolic health (MH) and reduced cardiorespiratory fitness (CRF) are independently associated with increased carotid intima-media thickness (cIMT) in obese subjects. Metabolically healthy obesity (MHO) has higher cIMT compared to metabolically healthy normal weight (MHNW) subjects, but this difference becomes statistically nonsignificant when cardiorespiratory fitness is taken into account. These results suggest that low CRF may explain part of the increased CVD risk observed in MHO compared with MHNW.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Sport Sciences
Stephen W. Farrell, David Leonard, Carolyn E. Barlow, Benjamin L. Willis, Andjelka Pavlovic, Laura F. Defina, William L. Haskell
Summary: This study found strong individual and joint associations between low cardiorespiratory fitness, vitamin D deficiency, and metabolic syndrome among U.S. adult men. Maintaining proper levels of fitness and vitamin D can help reduce the risk of metabolic syndrome. Prospective studies are needed to further evaluate these joint associations with mortality outcomes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Endocrinology & Metabolism
Brittany E. Smith, James E. Peterman, Matthew P. Harber, Mary T. Imboden, Bradley S. Fleenor, Leonard A. Kaminsky, Mitchell H. Whaley
Summary: This study demonstrates the significant relationship between changes in cardiorespiratory fitness and metabolic syndrome following exercise training. Participating in a community-based exercise program can lead to improvements in cardiorespiratory fitness, metabolic syndrome risk factors, prevalence of metabolic syndrome, and its severity score. Improving cardiorespiratory fitness through exercise training should be prioritized for preventing metabolic syndrome.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Sport Sciences
Andrew O. Agbaje, Alan R. Barker, Tomi-Pekka Tuomainen
Summary: This study found that cardiorespiratory fitness is associated with arterial function and structure in 9-11-year-old children. Higher cardiorespiratory fitness and lean mass are positively related to arterial structure, while higher cardiorespiratory fitness and fat mass are negatively related to arterial function. Cardiorespiratory fitness partially mediates the relationship between cardiometabolic health and arterial outcomes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Medicine, General & Internal
Palakben Hasmukhbhai Patel, Mitchell Gates, Peter Kokkinos, Carl J. Lavie, Jiajia Zhang, Xuemei Sui
Summary: The study found an inverse association between non-exercise estimated cardiorespiratory fitness and incident hypertension by sex. Men with higher levels of cardiorespiratory fitness had a lower risk of developing hypertension, as did women. Each 1-MET increment in fitness was associated with a 10% higher risk of incident hypertension in the overall sample.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Mena Farazi, Ahmad Jayedi, Fatemeh Dehghani Firouzabadi, Zahra Noruzi, Hanieh Moosavi, Kurosh Djafarian, Sakineh Shab-Bidar
Summary: Our study found that there was no significant association between serum vitamin D and obesity or MetSyn, but CRF showed a strong inverse association with overall and abdominal obesity. The inverse association between CRF and obesity was stronger in individuals with high serum vitamin D, and this joint association remained significant even after controlling for age and diet quality.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Jairo Azocar-Gallardo, Alex Ojeda-Aravena, Eduardo Baez-San Martin, Victor Campos-Uribe, Luis Gonzalez-Rojas, Maria A. Castillo Cerda, Jose Manuel Garcia-Garcia
Summary: The aim of this study was to determine the influence of body composition on cardiorespiratory fitness and metabolic markers. The results showed that higher fat-free mass and lower body mass index were positively related to better cardiorespiratory fitness, regardless of insulin resistance status.
APPLIED SCIENCES-BASEL
(2023)
Article
Pediatrics
Ana Paula Sehn, Caroline Brand, Leticia Welser, Anelise Reis Gaya, Cesar Agostinis-Sobrinho, Carlos Cristi-Montero, Elza Daniel de Mello, Cezane Priscila Reuter
Summary: This study found that cardiorespiratory fitness (CRF) is inversely associated with neck circumference (NC) and acts as a moderator in the relationship between NC and cardiometabolic risk in children and adolescents. Increasing CRF levels may attenuate the detrimental health impact associated with fatness.
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Metabolic syndrome is a complex metabolic disorder characterized by obesity, insulin resistance/diabetes, hyperlipidemia, and hypertension. The increasing incidence of metabolic syndrome poses a heavy medical burden, yet effective prevention and treatment strategies are still lacking. Fibroblast growth factor 21 (FGF21) is a key protein involved in maintaining metabolic homeostasis and has potential as a target for the treatment of metabolic syndrome by reducing fat mass and improving glucose and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Medicinal
Azar Hosseini, Bibi Marjan Razavi, Maciej Banach, Hossein Hosseinzadeh
Summary: Quercetin, as an important flavonoid, has potential effects in improving symptoms of metabolic syndrome, but further research and clinical trials are needed to determine its true clinical value.
PHYTOTHERAPY RESEARCH
(2021)
Article
Sport Sciences
Eva C. Diaz, Judith L. Weber, Sean H. Adams, Catarina G. Young, Shasha Bai, Elisabet Borsheim
Summary: This study found that higher cardiorespiratory fitness is associated with reduced probability of clinical high blood pressure, lower insulin resistance, and improved liver function in children with excessive adiposity. Blood pressure percentiles and kidney function improved with increasing cardiorespiratory fitness regardless of adiposity status.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Clinical Neurology
W. Wichayanrat, S. Boripuntakul, P. Keawtep, P. Worakul, S. Sungkarat
Summary: The study found that obese middle-aged women showed significantly lower scores in multiple cognitive functions, especially when combined with Metabolic Syndrome. However, high cardiorespiratory fitness was shown to have benefits on certain aspects of cognitive performance. Maintaining a healthy weight and improving CRF are beneficial for cognitive function in middle-aged women.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Edda Bahlmann, Eigir Einarsen, Dana Cramariuc, Eva R. Pedersen, Anne B. Rossebo, Helga Midtbo, Stephan Willems, Eva Gerdts
Summary: This study suggests that asymptomatic AS patients who have discordant grading after adjustment for pressure recovery are at increased cardiovascular risk, including heart failure and death.
Article
Peripheral Vascular Disease
Gyda Ullensvang, Ester Kringeland, Eirik Ikdahl, Sella Provan, Inger Jorid Berg, Silvia Rollefstad, Hanne Dagfinrud, Eva Gerdts, Anne Grete Semb, Helga Midtbo
Summary: This study investigated the prevalence of cardiovascular organ damage associated with hypertension in patients with ankylosing spondylitis (AS). The results showed that 34% of AS patients had hypertension, and 84% of AS patients with hypertension had cardiovascular organ damage. These findings highlight the importance of guideline-directed hypertension management in AS patients to reduce cardiovascular disease.
Article
Peripheral Vascular Disease
Annabel Eide Ohldieck, Ester Kringeland, Helga Midtbo, Grethe S. Tell, Eva Gerdts
Summary: This study aimed to identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. The results showed that high-normal blood pressure in midlife was a significantly stronger risk factor for the development of hypertension in women than in men during follow-up, independent of body mass index.
Article
Cardiac & Cardiovascular Systems
Dana Cramariuc, Hassan Alfraidi, Yasufumi Nagata, Robert A. Levine, Antonia van Kampen, Carl Andrews, Judy Hung
Summary: This study assessed the impact of left atrial function on prognosis in atrial functional mitral regurgitation (AFMR). The results showed that lower left atrial strain and estimated reservoir work were associated with higher risk of death and heart failure hospitalization, while left atrial size was not related to prognosis.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dana Cramariuc, Stig Urheim
Article
Medicine, General & Internal
Katrine Tryti Lindseth, Eva Gerdts, Helga Midtbo, Nadia Pristaj, Dana Cramariuc, Eigir Einarsen
Summary: This study investigated the relation between global myocardial work index (GWI) and sex and increased body mass index (BMI). The results showed that women had higher GWI, which was mainly explained by increased left ventricular (LV) workload due to higher aortic augmentation pressure in women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
John G. Eikas, Eva Gerdts, Hilde Halland, Helga Midtbo, Dana Cramariuc, Ester Kringeland
Summary: This study explored sex differences in arterial stiffness among individuals with overweight and obesity. Women had higher augmentation pressure and augmentation index, while men had higher carotid-femoral pulse wave velocity. Age and 24-hour systolic blood pressure were the main factors associated with arterial stiffness in both sexes.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Midtboe, A. Ulvik, K. Meyer, D. Cramariuc, P. M. Ueland, H. Halland, E. Gerdts
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Dana Cramariuc, Hassan Alfraidi, Yasufumi Nagata, Robert Levine, Carl Andrews, Judy Hung
Meeting Abstract
Cardiac & Cardiovascular Systems
Christian Engelsen Berg-Hansen, Rasmus S. Bach, Lisa M. Grymyr, Stig Urheim, Barbara P. Rogge, Robert M. Persson, Dana Cramariuc
Review
Cardiac & Cardiovascular Systems
Enxhela Sulo, Einar Skulstad Davidsen, Mai Tone Lonnebakken, Oyvind Bleie, Sahrai Saeed
Summary: This study reported paradoxical sinus deceleration observed during dobutamine stress echocardiography in six patients and described its occurrence patterns and clinical characteristics. The deceleration mainly occurred at maximal dobutamine infusion, accompanied by a decrease in blood pressure and resolved spontaneously after cessation of dobutamine infusion. Patients experiencing paradoxical sinus deceleration commonly had abnormal left ventricle geometry but differed in terms of age, sex, and cardiometabolic risk factors.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Article
Peripheral Vascular Disease
Silje Kjellevold Storesund, Iman Karaji, Elin Strand, Asbjorn Svardal, Mai Tone Lonnebakken, Rolf Kristian Berge, Gard Frodahl Tveitevag Svingen, Ottar Kjell Nygard, Eva Ringdal Pedersen
Summary: This study explored the predictive role of carnitine metabolites in cardiovascular disease and all-cause mortality among patients with non-obstructive coronary artery disease. The results showed that serum levels of acetyl, octanoyl-, and palmitoylcarnitine were associated with CVD mortality. Higher levels of acetyl- and palmitoylcarnitine were also linked to increased risk of all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2022)
Article
Multidisciplinary Sciences
Caroline A. Berge, Ingeborg Eskerud, Elise B. Almeland, Terje H. Larsen, Eva R. Pedersen, Svein Rotevatn, Mai Tone Lonnebakken
Summary: This study aimed to investigate the association between hypertension and extensive non-obstructive coronary artery disease (CAD) in patients with symptomatic chronic coronary syndrome (CCS). The results showed that hypertension was associated with extensive non-obstructive CAD in CCS patients, independent of factors such as sex, age, smoking, diabetes, statin treatment, obesity, and calcium score.