Article
Oncology
Kimberly B. Johansson, Megan S. Zimmerman, Iryna V. Dmytrenko, Feng Gao, Daniel C. Link
Summary: The combination of idasanutlin and navitoclax shows high activity in T-ALL, inducing synergistic killing of cancer cells and increasing overall survival. This finding highlights the potential clinical significance of this combination therapy.
Article
Cell Biology
Albert Manzano-Munoz, Clara Alcon, Pablo Menendez, Manuel Ramirez, Felix Seyfried, Klaus-Michael Debatin, Luder H. Meyer, Josep Samitier, Joan Montero
Summary: Multiple targeted therapies are being explored for improving clinical outcome in pediatric and young adult BCP-ALL, especially for relapsed patients. Using DBP evaluation, MEK inhibitor trametinib and multi-target tyrosine kinase inhibitor sunitinib were found to enhance apoptotic priming in NRAS-mutant and KMT2A-rearranged cell lines with high FLT3 expression, respectively.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Monika Lejman, Aleksandra Chalupnik, Zuzanna Chilimoniuk, Maciej Dobosz
Summary: Acute lymphoblastic leukemia is a heterogeneous disease characterized by abnormal proliferation of immature lymphoid cells. The study of genomic alterations has identified new subtypes of this disease and these genetic abnormalities play important roles in early disease detection, risk stratification, and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Amber Gibson, Adriana Trabal, David McCall, Sajad Khazal, Laurie Toepfer, Donna H. Bell, Michael Roth, Kris M. Mahadeo, Cesar Nunez, Nicholas J. Short, Courtney DiNardo, Marina Konopleva, Ghayas C. Issa, Farhad Ravandi, Nitin Jain, Gautam Borthakur, Hagop M. Kantarjian, Elias Jabbour, Branko Cuglievan
Summary: This study retrospectively reviewed the safety and efficacy of Venetoclax in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoma (LBL). The results showed that Venetoclax is safe and effective to use in pediatric patients with ALL/LBL and should be considered in both the relapsed and upfront settings.
Article
Biochemistry & Molecular Biology
Krzysztof Jedraszek, Marta Malczewska, Karolina Parysek-Wojcik, Monika Lejman
Summary: Despite advances in medicine, acute lymphoblastic leukemia (ALL) remains a challenge for pediatric clinicians due to treatment resistance and disease relapse. This article focuses on B-cell leukemia patients and examines prognostic factors, mechanisms of resistance to therapy, and the impact of genetic factors, including TCF3::HLF translocation. It also compares treatment protocols and explores the resistance of cancer cells to innovative therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Immunology
Salvador Valle-Reyes, Oxana Dobrovinskaya, Rosana Pelayo, Michael Schnoor
Summary: A significant amount of knowledge on T and B cell biology is obtained from research using ALL cell lines, which are crucial tools in immunology and leukemia studies. Understanding the advantages and limitations of ALL cell lines is important for their proper utilization.
TRENDS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Tiago Oliveira, Mingfeng Zhang, Eun Ji Joo, Hisham Abdel-Azim, Chun-Wei Chen, Lu Yang, Chih-Hsing Chou, Xi Qin, Jianjun Chen, Kathirvel Alagesan, Andreia Almeida, Francis Jacob, Nicolle H. Packer, Mark von Itzstein, Nora Heisterkamp, Daniel Kolarich
Summary: This study integrated transcriptomics, proteomics and glycomics data to reveal extensive remodeling of glycocalyx in MLL-r cells, identifying potential therapeutic targets and previously unknown protein targets. The research demonstrated the importance of a systematic combined multi-omics approach in providing important diagnostic information that may be missed with a single omics technology.
Review
Biochemistry & Molecular Biology
Oriol de Barrios, Maribel Parra
Summary: BCP-ALL is a highly aggressive malignancy with worse prognosis in infants. Genetic signatures and epigenetic alterations play a role in leukemogenesis, with DNA methylation patterns and histone modifications impacting oncogene activation. An integrated understanding of epigenetic disorders is crucial for improving therapeutic options and disease prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Oncology
Illya Martynov, Joachim Schoenberger
Summary: This retrospective study evaluated the safety of placing tunneled central venous catheters (TCVCs) in neutropenic children with acute leukemia, showing that TCVC placement is safe and not associated with an increased risk of central line-associated bloodstream infections (CLABSI). Female sex and the use of TCVC for treatment of relapsed leukemia were identified as risk factors for early CLABSI, while the use of double-lumen catheters and TCVCs during leukemia relapse were identified as risk factors for overall CLABSI rates.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Hoa Thi Kim Nguyen, Michael A. Terao, Daniel M. Green, Ching-Hon Pui, Hiroto Inaba
Summary: Acute lymphoblastic leukemia (ALL) in children and adolescents can involve the testes at diagnosis or upon relapse. Modern intensive chemotherapy has largely eradicated testicular relapse in high-income countries. However, testicular relapse continues to be a significant problem in low- and middle-income countries that have not had access to modern intensive chemotherapy. Additional research and discussion are needed to further explore management strategies for testicular relapse in these regions.
Article
Oncology
Emanuele Murgo, Elisabetta De Santis, Francesca Sansico, Valentina Melocchi, Tommaso Colangelo, Costanzo Padovano, Mattia Colucci, Annalucia Carbone, Beatrice Totti, Alireza Basti, Lisa Gottschlich, Angela Relogio, Nazzareno Capitanio, Fabrizio Bianchi, Gianluigi Mazzoccoli, Vincenzo Giambra
Summary: This study investigates the role of the biological clock in the regulation of cellular dynamics in T-ALL. The disruption of the circadian clock negatively affects LIC activity and JAK/STAT signaling in T-ALL cells. Targeting circadian components could be a potential therapeutic strategy for T-ALL treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qingkai Dai, Ge Zhang, Yuefang Wang, Lei Ye, Rui Shi, Luyun Peng, Siqi Guo, Jiajing He, Hao Yang, Yingjun Zhang, Yongmei Jiang
Summary: This study aimed to evaluate the cytokine network in peripheral blood of newly diagnosed pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL). Results showed that B-ALL patients had significantly elevated levels of IL-6, IL-10, and IFN-γ, and significantly decreased levels of TGF-β1. Higher concentrations of pro-inflammatory cytokines were associated with fever in patients. These findings highlight the critical role of aberrant cytokine expression in the progression of childhood B-ALL.
Article
Medicine, General & Internal
Robert Chiesa, Christos Georgiadis, Farhatullah Syed, Hong Zhan, Annie Etuk, Soragia Athina Gkazi, Roland Preece, Giorgio Ottaviano, Toni Braybrook, Jan Chu, Agnieszka Kubat, Stuart Adams, Rebecca Thomas, Kimberly Gilmour, David O'Connor, Ajay Vora, Waseem Qasim
Summary: Base editing technique has been used to inactivate genes and treat relapsed childhood T-cell leukemia with promising results.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cell Biology
Mayumi Sugita, Takahiro Yamazaki, Mohammad Alhomoud, Jeremie Martinet, Jean-Baptiste Latouche, Encouse Golden, Olivier Boyer, Koen Van Besien, Silvia C. Formenti, Lorenzo Galluzzi, Monica L. Guzman
Summary: Autologous T cells engineered with CAR specific for CD19 have been approved for treating CD19(+) hematological malignancies. However, relapse often occurs when neoplastic cells lose CD19 expression. Preclinical models have shown that radiation therapy (RT) can overcome CD19 loss by inducing death receptor expression in cancer cells. Using a human model of CD19(+) acute lymphoblastic leukemia (ALL), it was found that low-dose total body irradiation (LD-TBI) administered before CAR T cell infusion significantly improved overall survival and CAR T cell expansion. These findings support the initiation of clinical trials combining LD-TBI with CAR T cells.
CELL DEATH & DISEASE
(2023)
Article
Rheumatology
Andrew P. Cope, Michael R. Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A. Fisher, Carl S. Goodyear, Paul Emery, Michael R. Ehrenstein, Neil Gozzard, Ray Harris, Sally Hollis, Sarah Keidel, Marc Levesque, Catharina Lindholm, Michael F. McDermott, Iain B. McInnes, Christopher M. Mela, Gerry Parker, Simon Read, Ayako Wakatsuki Pedersen, Frederique Ponchel, Duncan Porter, Ravi Rao, Anthony Rowe, Peter Schulze-Knappe, Matthew A. Sleeman, Deborah Symmons, Peter C. Taylor, Brian Tom, Wayne Tsuji, Denny Verbeeck, John D. Isaacs
NATURE REVIEWS RHEUMATOLOGY
(2018)
Article
Immunology
Mehmet Onur Elbasi, Aysin Tulunay Virlan, Emel Eksioglu Demiralp
Correction
Rheumatology
Andrew P. Cope, Michael R. Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A. Fisher, Carl S. Goodyear, Paul Emery, Michael R. Ehrenstein, Neil Gozzard, Ray Harris, Sally Hollis, Sarah Keidel, Marc Levesque, Catharina Lindholm, Michael F. McDermott, Iain B. McInnes, Christopher M. Mela, Gerry Parker, Simon Read, Ayako Wakatsuki Pedersen, Frederique Ponchel, Duncan Porter, Ravi Rao, Anthony Rowe, Peter Schulz-Knappe, Matthew A. Sleeman, Deborah Symmons, Peter C. Taylor, Brian Tom, Wayne Tsuji, Denny Verbeeck, John D. Isaacs
NATURE REVIEWS RHEUMATOLOGY
(2018)
Review
Immunology
Lauren Kelly, Sarah McGrath, Lewis Rodgers, Kathryn McCall, Aysin Tulunay Virlan, Fiona Dempsey, Scott Crichton, Carl S. Goodyear
Summary: Annexin-A1 has a well-defined anti-inflammatory role in the innate immune system, but its function in adaptive immunity is still controversial. It is implicated in inflammatory conditions, cancers, and autoimmune diseases, and it may serve as a potential biomarker and therapeutic target.
Article
Transplantation
Neslihan Tezcan, Zarife Nigar Ozdemir-Kumral, Naziye Ozkan Yenal, Ozlem T. Cilingir-Kaya, Aysin Tulunay Virlan, Dilek Ozbeyli, Sule Cetinel, Berrak C. Yegen, Mehmet Koc
Summary: The study demonstrates that NES-1 has renoprotective effects and can ameliorate renal fibrosis induced by unilateral ureteral obstruction. The mechanism may involve inhibition of neutrophil infiltration, reduction of oxidative stress, and inflammation. These findings suggest that NES-1 may play a regulatory role in protecting the kidneys against obstruction-induced renal injury.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
John D. Isaacs, Sarah Brockbank, Ayako Wakatsuki Pedersen, Catharien Hilkens, Amy Anderson, Philip Stocks, Dennis Lendrem, Jessica Tarn, Graham R. Smith, Ben Allen, John Casement, Julie Diboll, Rachel Harry, Faye A. H. Cooles, Andrew P. Cope, Gemma Simpson, Ruth Toward, Hayley Noble, Angela Parke, Wing Wu, Fiona Clarke, David Scott, Ian C. Scott, James Galloway, Heidi Lempp, Fowzia Ibrahim, Samana Schwank, Gemma Molyneux, Tomi Lazarov, Frederic Geissmann, Carl S. Goodyear, Iain B. McInnes, Iona Donnelly, Ashley Gilmour, Aysin Tulunay Virlan, Duncan Porter, Frederique Ponchel, Paul Emery, Jehan El-Jawhari, Rekha Parmar, Michael F. McDermott, Benjamin A. Fisher, Steve P. Young, Philip Jones, Karim Raza, Andrew Filer, Costantino Pitzalis, Michael R. Barnes, David S. Watson, Rafael Henkin, Georgina Thorborn, Liliane Fossati-Jimack, Stephen Kelly, Frances Humby, Michele Bombardieri, Sharmila Rana, Zhilong Jia, Katriona Goldmann, Myles Lewis, Sandra Ng, Adriano Barbosa-Silva, Evan Tzanis, Amaya Gallagher-Syed, Christopher R. John, Michael R. Ehrenstein, Gioia Altobelli, Sandra Martins, Dao Nguyen, Humayara Ali, Coziana Ciurtin, Maya Buch, Deborah Symmons, Jane Worthington, Ian N. Bruce, Jamie C. Sergeant, Suzanne M. M. Verstappen, Fiona Stirling, Adwoa Hughes-Morley, Brian Tom, Vernon Farewell, Yujie Zhong, Peter C. Taylor, Christopher D. Buckley, Sarah Keidel, Carolyn Cuff, Marc Levesque, Andrew Long, Zheng Liu, Samantha Lipsky, Bohdan Harvey, Michael Macoritto, Feng Hong, Sukru Kaymakcalan, Wayne Tsuji, Tony Sabin, Neil Ward, Susan Talbot, Desmond Padhji, Matthew Sleeman, Donna Finch, Athula Herath, Catharina Lindholm, Martin Jenkins, Meilien Ho, Sally Hollis, Chris Marshall, Gerry Parker, Matt Page, Hannah Edwards, Alexandru Cuza, Neil Gozzard, Ioannis Pandis, Anthony Rowe, Francisco Bonachela Capdevila, Matthew J. Loza, Mark Curran, Denny Verbeeck, Dan Baker, Christopher M. Mela, Ivana Vranic, Catherine T. Mela, Stephen Wright, Lucy Rowell, Emma Vernon, Nina Joseph, Neil Payne, Ravi Rao, Michael Binks, Alexandra Belson, Valerie Ludbrook, Kirsty Hicks, Hannah Tipney, Joanne Ellis, Samiul Hasan, Arnaud Didierlaurent, Wivine Burny, Andrea Haynes, Chris Larminie, Ray Harris, Daniela Dastros-Pitei, Claudio Carini, Blerina Kola, Scott Jelinsky, Martin Hodge, Mateusz Maciejewski, Daniel Ziemek, Peter Schulz-Knappe, Hans-Dieter Zucht, Petra Budde, Mark Coles, James A. Butler, Simon Read
Summary: This study conducted comprehensive clinical and molecular profiling of early, drug naive RA patients, establishing a high-quality sample biobank and performing multi-omic immune phenotyping. The data obtained is expected to provide important insights into the pathogenesis, progression, and therapeutic response of RA.
Article
Obstetrics & Gynecology
Mehmet Onur Elbasi, Aysin Tulunay, Hale Karagozoglu, Semra Kahraman, Emel Eksioglu-Demiralp
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2020)
Article
Zoology
Ahmet Ozer Sehirli, Serkan Sayiner, Ayliz Velioglu-Ogunc, Nedime Serakinci, Emel Eksioglu-Demiralp, Berrak Yegen, Feriha Ercan, Goksel Sener
PAKISTAN JOURNAL OF ZOOLOGY
(2020)
Review
Urology & Nephrology
Emel Eksioglu-Demiralp, Mehmet Onur Elbasi, Aydin Turkmen
TURKISH JOURNAL OF NEPHROLOGY
(2019)
Article
Medicine, General & Internal
Banu Aydin, Aysin Tulunay, Emel Eksioglu-Demiralp, Beki Kan, Hulya Cabadak
MARMARA MEDICAL JOURNAL
(2019)
Article
Surgery
Wafi Attaallah, Leyla Semiha Sen, Ahmet Ozdemir Aktan, Emel Demiralp Eksioglu, Zeynep Eti, Sertac Ata Guler, Asim Cingi
TURKISH JOURNAL OF SURGERY
(2018)
Article
Rheumatology
Brian D. M. Tom, Deborah Symmons, Sarah Brockbank, Claudio Carini, Andrew P. Cope, Michael R. Ehrenstein, Benjamin A. Fisher, Carl S. Goodyear, Neil Gozzard, Ray Harris, Kirsty Hicks, Sally Hollis, Adwoa Hughes-Morley, John Isaacs, Blerina Kola, Iain B. McInnes, Christopher M. Mela, Gerry Parker, Ayako Wakatsuki Pedersen, Frederique Ponchel, Tony Sabin, David L. Scott, Ian C. Scott, Matthew A. Sleeman, Peter C. Taylor, Wayne Tsuji, Yujie Zhong, Catharien Hilkens, Amy Anderson, Philip Stocks, Dennis Lendrem, Jessica Tarn, Graham Smith, Ben Allen, John Casement, Julie Diboll, Rachel Harry, Gemma Simpson, Ruth Toward, Hayley Noble, Angela Parke, Wing Wu, Fiona Clarke, James Galloway, Heidi Lempp, Fowzia Ibrahim, Samana Schwank, Gemma Molyneux, Tomi Lazarov, Frederic Geissmann, Iona Donnelly, Ashley Gilmour, Aysin Tulunay Virlan, Duncan Porter, Paul Emery, Jehan El-Jawhari, Rekha Parmar, Michael F. McDermot, Maya Buch, Chris Buckley, Steve P. Young, Philip Jones, Karim Raza, Andrew Filer, Costantino Pitzalis, Michael R. Barnes, David S. Watson, Evan Tzanis, Georgina Thorborn, Liliane Fossati-Jimack, Stephen Kelly, Frances Humby, Michele Bombardieri, Sharmila Rana, Zhilong Jia, Katriona Goldmann, Myles Lewis, Gioia Altobelli, Chris John, Sandra Martins, Dao Nguyen, Humayara Ali, Coziana Ciurtin, Jane Worthington, Ian N. Bruce, Jamie C. Sergeant, Suzanne M. M. Verstappen, Fiona Stirling, Vernon Farewell, Sarah Keidel, Carolyn Cuff, Marc Levesque, Andrew Long, Zheng Liu, Samantha Lipsky, Bohdan Harvey, Michael Macoritto, Feng Hong, Sukru Kaymakcalan, Neil Ward, Susan Talbot, Desmond Padhji, Matthew Sleeman, Donna Finch, Athula Herath, Catharina Lindholm, Martin Jenkins, Meilien Ho, Chris Marshall, Matt Page, Hannah Edwards, Alexandru Cuza, Anthony Rowe, Francisco Bonachela Capdevila, Matthew Loza, Mark Curran, Denny Verbeeck, Dan Baker, Ivana Vranic, Catherine T. Mela, Stephen Wright, Lucy Rowell, Emma Vernon, Nina Joseph, Neil Payne, Ravi Rao, Michael Binks, Alexandra Belson, Valerie Ludbrook, Hannah Tipney, Joanne Ellis, Samiul Hasan, Arnaud Didierlaurent, Wivine Burny, Andrea Haynes, Chris Larminie, Daniela Dastros-Pitel, Scott Jelinsky, Martin Hodge, Mateusz Maciejewski, Daniel Ziemek, Peter Schulz-Knappe, Hans-Dieter Zucht, Petra Budde, Mark C. Coles, James A. Butler, Simon Read
Meeting Abstract
Surgery
E. Eksioglu-Demiralp, A. Turkmen, B. Yelken, S. Gorcin, O. Elbasi, F. Yalcin, B. Kocak, C. Karatas, M. Tuncer, M. Altinel
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
