Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy

Peripheral neuropathy via mutant tRNA synthetases: Inhibition of protein translation provides a possible explanation

(2016) Erik Storkebaum   BIOESSAYS

Loss of function mutations inHARScause a spectrum of inherited peripheral neuropathies

(2015) Dana Safka Brozkova et al.   BRAIN

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

(2015) Weiwei He et al.   NATURE

Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

(2015) Sven Niehues et al.   Nature Communications

Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy

(2015) Claudia Gonzaga-Jauregui et al.   Cell Reports

Mechanisms of protein-folding diseases at a glance

(2014) J. S. Valastyan et al.   Disease Models & Mechanisms

Oxidative Stress Diverts tRNA Synthetase to Nucleus for Protection against DNA Damage

(2014) Na Wei et al.   MOLECULAR CELL

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Insights into Fibrinogen Dynamics Using Amide Hydrogen/Deuterium Exchange Mass Spectrometry

(2013) James J. Marsh et al.   BIOCHEMISTRY

Rare variants inmethionyl- andtyrosyl-tRNA synthetasegenes in late-onset autosomal dominant Charcot-Marie-Tooth neuropathy

(2013) Y.S. Hyun et al.   CLINICAL GENETICS

Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2

(2013) Michael Gonzalez et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Molecular Dynamics of DNA–Protein Conjugates on Electrified Surfaces: Solutions to the Drift-Diffusion Equation

(2013) A. Langer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Uncovering of a Short Internal Peptide Activates a tRNA Synthetase Procytokine

(2012) Peter S. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

tRNA-controlled Nuclear Import of a Human tRNA Synthetase

(2012) Guangsen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minimizing Back Exchange in the Hydrogen Exchange-Mass Spectrometry Experiment

(2012) Benjamin T. Walters et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Unique domain appended to vertebrate tRNA synthetase is essential for vascular development

(2012) Xiaoling Xu et al.   Nature Communications

Dominant Intermediate Charcot-Marie-Tooth Disorder Is Not Due to a Catalytic Defect in Tyrosyl-tRNA Synthetase

(2011) Clifford A. Froelich et al.   BIOCHEMISTRY

Mechanism of Intracellular cAMP Sensor Epac2 Activation

(2011) Sheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening

(2011) W. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Determinant for Binding and Aminoacylation of tRNAAla in Cytoplasmic Alanyl-tRNA Synthetase Is Mutated in Dominant Axonal Charcot-Marie-Tooth Disease

(2010) Philippe Latour et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Compound Heterozygosity for Loss-of-Function Lysyl-tRNA Synthetase Mutations in a Patient with Peripheral Neuropathy

(2010) Heather M. McLaughlin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations

(2010) Morgane Stum et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

New functions of aminoacyl-tRNA synthetases beyond translation

(2010) Min Guo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GARS axonopathy: not every neuron's cup of tRNA

(2010) William W. Motley et al.   TRENDS IN NEUROSCIENCES

Functional expansion of human tRNA synthetases achieved by structural inventions

(2009) Min Guo et al.   FEBS LETTERS

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality

(2009) Quansheng Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved MutS homolog connector domain interface interacts with MutL homologs

(2009) Marc L. Mendillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate inDrosophilafeatures of human Charcot–Marie–Tooth neuropathy

(2009) Erik Storkebaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases

(2007) Lee Whitmore et al.   BIOPOLYMERS