Journal
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
Volume 44, Issue 4, Pages 843-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2015.07.008
Keywords
Testis development; Reproductive options; Klinefelter syndrome; Testicular function; Spermatogenesis; X-chromosome; Sex chromosome aneuploidy
Categories
Funding
- NIDDK NIH HHS [T32 DK063687] Funding Source: Medline
- NINDS NIH HHS [R01 NS050597] Funding Source: Medline
Ask authors/readers for more resources
Klinefelter syndrome (KS) is the leading genetic cause of primary hypogonadism and infertility in men. The clinical phenotype has expanded beyond the original description of infertility, small testes, and gynecomastia. Animal models, epidemiologic studies, and clinical research of male subjects with KS throughout the lifespan have allowed the better characterization of the variable phenotype of this condition. This review provides an overview on what is known of the epidemiology, clinical features, and pathophysiology of KS, followed by a more focused discussion of testicular development and the clinical management of hypogonadism and fertility in boys and men with KS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available