Article
Endocrinology & Metabolism
Ashley J. Han, Elena V. Varlamov, Maria Fleseriu
Summary: This study characterized the clinical features and natural history of nonfunctioning pituitary microadenomas and found that they are generally benign. It suggests that the initial MRI follow-up interval for these tumors can be extended up to 3 years, unless there are specific concerns.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Keyi Zhang, Xuefei Shou, Hong Chen, Nidan Qiao, Wenqiang He, Zhengyuan Chen, Ming Shen, Shiqi Li, Yao Zhao, Zhaoyun Zhang, Yiming Li, Hongying Ye, Yongfei Wang
Summary: The study investigated the clinical characteristics of SCAs with positive and negative ACTH immunostaining, finding that ACTH-negative SCAs were more clinically silent and more likely to demonstrate multiple microcysts on MRI. The prevalence of SCAs, especially ACTH-negative SCAs, was substantially underestimated and should be given enough attention due to the high aggressiveness of this subtype of refractory pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Ben A. Strickland, Shane Shahrestani, Robert G. Briggs, Anna Jackanich, Sherwin Tavakol, Kyle Hurth, Mark S. Shiroishi, Chia-Shang J. Liu, John D. Carmichael, Martin Weiss, Gabriel Zada
Summary: SCAs are a subtype of NFAs that are more biologically aggressive, with patients presenting with more cranial neuropathy and headaches, and a shorter progression-free survival duration.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Kihwan Hwang, Yong Hwy Kim, Jung Hee Kim, Jung Hyun Lee, Hee Kyung Yang, Jeong-Min Hwang, Chae-Yong Kim, Jung Ho Han
Summary: The study on the natural history of asymptomatic nonfunctioning pituitary adenomas (NFPAs) with optic nerve compression showed that close follow-up and timely surgical intervention can effectively prevent visual and endocrine issues for cases with optic nerve compression, and conservative management is also acceptable for these tumors. Careful follow-up is necessary for tumors with cavernous sinus invasion.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Yoon-Hee Choo, Youngbeom Seo, Oh-Lyong Kim
Summary: This study retrospectively analyzed the outcomes of the transsphenoidal approach for nonfunctioning pituitary adenomas treated at a single institute. The study found that the transsphenoidal approach is an effective and safe treatment, improving visual impairment and restoring endocrine function. Diabetes insipidus was the most common complication, and complete resection during surgery helped to lower the risk of recurrence.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Tobias Hallen, Gudmundur Johannsson, Rahil Dahlen, Camilla A. M. Glad, Charlotte Orndal, Angelica Engvall, Helena Caren, Thomas Skoglund, Daniel S. Olsson
Summary: This study explored DNA methylation patterns associated with tumor progression in patients with nonfunctioning pituitary adenomas (NFPAs). The results showed that some methylation sites were associated with tumor progression and could potentially serve as biomarkers for early identification of tumor progression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Yasuyuki Kinoshita, Akira Taguchi, Atsushi Tominaga, Kazunori Arita, Fumiyuki Yamasaki
Summary: Recovery from AGHD after initial TSS is more likely in younger female patients with higher peak GH levels assessed by preoperative PPT. Patients aged <= 62.2 years and with a peak GH level of >= 0.74 μg/L based on preoperative PPT are likely to recover from AGHD.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
David J. Cote, Jacob J. Ruzevick, Keiko M. Kang, Dhiraj J. Pangal, Ilaria Bove, John D. Carmichael, Mark S. Shiroishi, Ben A. Strickland, Gabriel Zada
Summary: In this study, lower zip code-level SES was associated with more severe disease at the time of diagnosis for NFPA patients, but there were no significant differences in short-term postoperative complications. Patients with higher zip code-level SES had higher rates of gross-total resection.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Mina M. Gerges, Kavelin Rumalla, Saniya S. Godil, Iyan Younus, Walid Elshamy, Georgiana A. Dobri, Ashutosh Kacker, Abtin Tabaee, Viay K. Anand, Theodore H. Schwartz
Summary: Following gross total resection of nonfunctioning pituitary adenomas, the 10-year chance of recurrence is low and the need for treatment even lower. After subtotal resection, upfront radiation therapy may prevent progression, but even without it, the need for intervention at 10 years is only approximately 20%, warranting a period of observation to prevent unnecessary prophylactic radiation therapy. Tumor volume > 1 cm(3), Knosp score >= 3, and Ki-67 >= 3% may prompt closer follow-up or justify early prophylactic radiation therapy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Yanli Li, Lisha Wu, Tingting Quan, Junyi Fu, Linhui Cao, Xi Li, Shunyao Liang, Minyi Huang, Yinhui Deng, Jinxiu Yu
Summary: This study aimed to report the characteristic of tumor regrowth after gamma knife radiosurgery (GKRS) and outcomes of repeat GKRS in nonfunctioning pituitary adenomas (NFPAs). The study found that parasellar invasion and tumor margin dose (<12 Gy) were independent risk factors for tumor regrowth after GKRS. Repeat GKRS might be effective on tumor control for selected patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Shenzhong Jiang, Xiaokun Chen, Yinzi Wu, Renzhi Wang, Xinjie Bao
Summary: The 2017 World Health Organization classification of endocrine tumors defines pituitary adenomas based on their cell lineages, with T-PIT serving as a complementary tool for identifying silent corticotroph adenomas (SCAs). Compared to functioning corticotroph adenomas, SCAs have a more aggressive course and resistance to conventional treatments due to intrinsic histological features. Molecular mechanisms studies of SCA pathogenesis are crucial for diagnosis and management. Understanding clinical features in the context of pathophysiology is important for optimal management, involving surgical, radiation, and/or medical therapies.
Article
Endocrinology & Metabolism
E. Biamonte, N. Betella, D. Milani, G. B. Lasio, S. Ariano, S. Radice, E. Lavezzi, G. Mazziotti, A. Lania
Summary: This study indicates that transnasal sphenoidal surgery is a safe therapeutic option for elderly patients with nonfunctioning pituitary adenomas, even in the presence of comorbidities and high anesthetic risk. Adenoma size is a determinant of peri-surgical complications, while the likelihood of normalizing at least one pituitary hormone deficiency is significantly associated with younger patient age.
Article
Oncology
Thomas Charleux, Veronique Vendrely, Aymeri Huchet, Renaud Trouette, Amandine Ferriere, Antoine Tabarin, Vincent Jecko, Hugues Loiseau, Charles Dupin
Summary: The first line of treatment for nonfunctioning pituitary adenoma (NFPA) is surgery. Adjuvant radiotherapy or surveillance and new treatment (second surgical operation or salvage radiotherapy) in case of recurrence are options discussed at the multidisciplinary tumor board. The purpose of this study was to evaluate the therapeutic outcome for each option. Results showed that adjuvant radiotherapy was not superior to salvage radiotherapy in preventing recurrence, therefore salvage radiotherapy is recommended in case of recurrence or progression to avoid a second surgical operation.
RADIATION ONCOLOGY
(2022)
